A5033219252- Cardiovascular Function and Risk Factors
- Pulmonary Hypertension Research and Treatments
- Cardiac Valve Diseases and Treatments
- Cardiac Imaging and Diagnostics
- Cardiovascular and exercise physiology
- Cardiac pacing and defibrillation studies
- Cardiovascular Effects of Exercise
- Heart Failure Treatment and Management
- Cardiac Arrhythmias and Treatments
- Hemodynamic Monitoring and Therapy
- Atrial Fibrillation Management and Outcomes
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiovascular and Diving-Related Complications
- Neurogenetic and Muscular Disorders Research
- Cardiomyopathy and Myosin Studies
- Erythropoietin and Anemia Treatment
- Mechanical Circulatory Support Devices
- Coronary Interventions and Diagnostics
- Body Composition Measurement Techniques
- Cardiac tumors and thrombi
- Genetic Syndromes and Imprinting
- Ultrasound in Clinical Applications
- Peripheral Artery Disease Management
- Genomics and Rare Diseases
- Heart Rate Variability and Autonomic Control
Hasselt University
2020-2025
Hartcentrum Hasselt
2021-2025
Jessa Hospital
2014-2024
University of Pisa
2024
Heart failure with preserved ejection fraction (HFpEF) is a syndrome heterogeneous presentation. This study provides an in-;depth description of haemodynamic and metabolic alterations revealed by systematic assessment through cardiopulmonary exercise testing combined echocardiography (CPETecho) within dedicated dyspnoea clinic.Consecutive patients (n = 297), referred to clinic using standardized workup including CPETecho, HFpEF diagnosed H2FPEF score ≥6 or HFA-PEFF ≥5, were evaluated. A...
Recent guidelines redefined exercise pulmonary hypertension as a mean artery pressure/cardiac output (mPAP/CO) slope >3 mm Hg·L
Abstract Background Exercise-induced pulmonary hypertension, characterized by mean artery pressure over cardiac output slope (mPAP/CO slope) > 3mmHg/L/min is associated with worse outcome in greater than moderate primary mitral regurgitation (PMR). However, the prognostic value of right ventricle to coupling (RVPAc) unknown. Purpose Assess RVPAc; determine additional exercise rest RVPAc and compare these findings mPAP/CO slope. Methods The single center study included consecutive...
Abstract Background Pulmonary artery pressure corrected for cardiac output (mPAP/CO) assessed by exercise echocardiography and calculated as the mPAP/CO slope improves risk stratification in various populations. However, it is unclear whether simplified alternatives have a similar predictive ability outcomes. Purpose To evaluate methodology employed to calculate affects prognostic assessment. Methods This secondary analysis of multicenter cohort study that included patients with unexplained...
Abstract Background According to the Fick equation, oxygen uptake (VO2) equals product of cardiac output (CO) and arteriovenous difference (a-vO2Diff). Cardiopulmonary exercise testing (CPET) provides pulse (O2pulse) as ratio VO2 heart rate. The O2pulse is often considered a surrogate for stroke volume (SV) during effort, ignoring AVO2Diff, assess hemodynamic response exercise. Purpose To compare SV measured independently by simultaneous CPET echocardiography (CPETecho). Methods Observation...
Abstract Aims Iron deficiency is common in heart failure with reduced ejection fraction (HFrEF). In patients cardiac resynchronization therapy (CRT), it associated a diminished reverse remodelling response and poor functional improvement. The latter partially related to loss contractile force at higher rates (negative force–frequency relationship). Methods results effect of intravenous ferric carboxymaltose on following (IRON‐CRT) trial multicentre, prospective, randomized, double‐blind...
To study the impact of heart failure with preserved ejection fraction (HFpEF) vs. aortic stenosis (AS) lesion severity on left ventricular (LV) hypertrophy, diastolic dysfunction, atrial (LA) haemodynamics, and exercise capacity.
Women are at greater risk for heart failure with preserved ejection fraction (HFpEF).
Half of patients with heart failure preserved ejection fraction (HFpEF) remain undiagnosed by resting evaluation alone. Therefore, exercise testing is proposed. The diastolic stress test (DST), however, has limited sensitivity. We aimed to determine the clinical significance adding mean pulmonary artery pressure over cardiac output (mPAP/CO) slope DST in suspected HFpEF.
Abstract Aims Low cardiorespiratory fitness (CRF) is associated with functional disability, heart failure and mortality. Left ventricular (LV) end-diastolic volume (LVEDV) has been linked CRF, but its utility as a diagnostic marker of low CRF not tested. Methods This multi-center international cohort examined the relationship between LV size on echocardiography (peak oxygen uptake [peak VO2] from cardiopulmonary exercise testing) in individuals ejection fraction ≥50%. Absolute BSA-indexed...
Cardiac output limitation is a fundamental feature of heart failure with preserved ejection fraction (HFpEF) but the relative contribution its determinants in symptomatic vs. asymptomatic stages are not well characterized. We aimed to gain insight into disease mechanisms by performing comprehensive comparative non-invasive exercise imaging patients across spectrum.We performed bicycle stress echocardiography 10 healthy controls, 13 hypertensive left ventricular (LV) concentric remodelling...