A5028749816- Congenital Heart Disease Studies
- Pulmonary Hypertension Research and Treatments
- Cardiovascular Function and Risk Factors
- Cardiac Structural Anomalies and Repair
- Cardiac Arrhythmias and Treatments
- Cardiac Valve Diseases and Treatments
- Cardiovascular and Diving-Related Complications
- Cardiovascular Issues in Pregnancy
- Cardiovascular Effects of Exercise
- Cardiac pacing and defibrillation studies
- Coronary Artery Anomalies
- Heart Failure Treatment and Management
- Cardiac Imaging and Diagnostics
- Aortic Disease and Treatment Approaches
- Transplantation: Methods and Outcomes
- Mechanical Circulatory Support Devices
- Infective Endocarditis Diagnosis and Management
- Cardiovascular Disease and Adiposity
- Cardiovascular and exercise physiology
- Atrial Fibrillation Management and Outcomes
- Renal and Vascular Pathologies
- Cardiac tumors and thrombi
- Tracheal and airway disorders
- Hemodynamic Monitoring and Therapy
- Frailty in Older Adults
KU Leuven
2016-2025
Universitair Ziekenhuis Leuven
2013-2025
Jessa Hospital
2014-2024
GTx (United States)
2024
Toronto General Hospital
2017-2023
University Health Network
2016-2023
Institució Catalana de Recerca i Estudis Avançats
2022
St Vincent's Hospital
2011-2014
The University of Melbourne
2011-2014
UCLouvain
2012
The ESC Guidelines represent the views of and were produced after careful consideration scientific medical knowledge, evidence available at time their publication.The is not responsible in event any contradiction, discrepancy, and/or ambiguity between other official recommendations or guidelines issued by relevant public health authorities, particular relation to good use healthcare therapeutic strategies.Health professionals are encouraged take fully into account when exercising clinical...
Accurate measures are critical when attempting to distinguish normal from pathological changes in cardiac function during exercise, yet imaging modalities have seldom been assessed against invasive exercise standards. We sought validate a novel method of biventricular volume quantification by MRI (CMR) maximal exercise.CMR was performed on 34 subjects and free-breathing with the use an ungated real-time (RT-ungated) CMR sequence. ECG respiratory movements were retrospectively synchronized,...
Patients with Fontan circulation have reduced exercise capacity. The absence of a presystemic pump may limit flow through the pulmonary circulation, restricting ventricular filling and cardiac output. We evaluated hemodynamics effect sildenafil on in patients.Ten patients (6 men, 20±4 years) underwent magnetic resonance imaging at rest during supine bicycle before after sildenafil. Systemic volumes were obtained low- (34±15 W), moderate- (69±29 high-intensity (97±36 W) using an ungated,...
Background Patients with a Fontan circulation achieve lower peak heart rates ( HR ) during exercise. Whether this impaired chronotropic response reflects pathology of the sinoatrial node or is consequence altered cardiac hemodynamics uncertain. We evaluated adequacy acceleration throughout exercise relative to metabolic demand and output in patients healthy controls. Methods Results Thirty subjects (20 controls 10 patients) underwent magnetic resonance imaging simultaneous invasive pressure...
Abstract Sudden cardiac death (SCD) accounts for up to 25% of deaths in patients with congenital heart disease (CHD). To date, research has largely been driven by observational studies and real-world experience. Drawbacks include varying definitions, incomplete taxonomy that considers SCD as a unitary diagnosis opposed terminal event diverse causes, inconsistent outcome ascertainment, limited data granularity. Notwithstanding these constraints, identified higher-risk substrates tetralogy...
Thanks to medical improvements in the care for patients with congenital heart disease (CHD), women CHD reach reproductive age. Pregnancy is not without risk due cardiovascular changes that occur. University Hospitals Leuven use a standardised protocol, including catheterisation and volume challenge, assess these before pregnancy. This protocol has never been evaluated. The primary aim was evaluate this challenge protocol. second objective investigate whether hemodynamic data obtained during...
AimsIron deficiency is common in patients with Eisenmenger syndrome (ES).This study aimed at evaluating (i) whether iron related adverse outcome, (ii) the determinants of deficiency, and (iii) relation between reserves haemoglobin level a contemporary cohort ES patients. Methods resultsAll patients, older than 18 years, selected from Belgian registry, were prospectively followed using web-based registry.Univariate Cox-regression analysis was performed to evaluate defined as all-cause...
Information on the prevalence, outcome and factors associated with heart failure in patients adult congenital disease (CHD) (ACHD-HF) is lacking. We aimed at assessing prevalence of ACHD-HF, variables differences between major anatomical/pathophysiological ACHD subgroups.We included 3905 (age 35.4 ± 13.2 years) under active follow-up our institution (last visit >2010). Outcome ACHD-HF cases was compared sex- age-matched cases. Univariable multivariable binary logistic regression diagnosis as...
Abstract Aims To investigate the incidence of major adverse ventricular arrhythmias and related events (MAREs) to develop a stratification tool predicting MAREs in adults with systemic right ventricle (sRV). Methods results In multicentre approach, all (≥16 years old) sRV undergoing follow-up between 2000 2018 were identified. The MAREs, defined as sudden cardiac death, sustained tachycardia, appropriate implantable cardioverter-defibrillator (ICD) therapy, was analysed. association...
Mice fully deficient in peptidylarginine deiminase 4 (PAD4) enzyme have preserved cardiac function and reduced collagen deposition during ageing. The cellular source of PAD4 is hypothesized to be neutrophils, likely due PAD4's involvement neutrophil extracellular trap release. We investigated haematopoietic impact on myocardial remodelling systemic inflammation ageing by generating mice with
Objectives: Studies evaluating the long-term outcome of adults with ventricular septal defect (VSD) are important to inform patients about prognosis. This study investigated perimembranous VSD (pmVSD) followed in Belgian Registry on Adult Congenital Heart Disease. Methods: All pmVSD registry were analyzed. Results: Two hundred and sixty-six studied. Fifteen had Eisenmenger syndrome. One seventy-three isolated 78 concomitant lesions. Of pmVSD, 52% male, median age was 29 years (IQR 24-35...
A patent foramen ovale (PFO) with atrial septal aneurysm (ASA) has been identified as a risk factor for cryptogenic stroke. Patients migraine aura (MA) appear to be at silent brain infarction, which might related the presence of PFO. However, association between MA and PFO ASA never reported. We examined this in large observational study.
Background Risk stratification for adults with congenital heart disease is usually based on the anatomic complexity of patients' defect. The 2018 American Heart Association/American College Cardiology guidelines management proposed a new classification scheme, combining and current physiological stage patient. We aimed to investigate capacity Adult Congenital Disease Anatomic Physiological predict 15-year mortality. Methods Results Data 5 systems were collected 629 patients at outpatient...
Atrial secondary mitral regurgitation (ASMR) is a clinically distinct form of Carpentier type I (MR), rooted in excessive atrial and annular dilation the absence left ventricular dysfunction. Mitral valve annuloplasty (MVA) expected to provide more durable solution for ASMR than MR (VSMR). Yet data on recurrence outcome after MVA are scarce. This study sought investigate surgical outcomes repair durability patients with ASMR, as compared contemporary group VSMR.Clinical echocardiographic...
Abstract Aims Atrial septal defect (ASD) and partial abnormal pulmonary venous connection (PAPVC) are noncyanotic congenital heart defects (CHD) that produce a left-to-right shunt. This single-center retrospective study aimed to assess the hemodynamic impact of isolated ASD, PAPVC, ASD-associated PAPVC using cardiovascular magnetic resonance (CMR). Methods Results From our CMR registry (2002-2024), 110 patients were included: ASD (n=64), (n=18), (n=28, mostly sinus venosus defects). included...
Abstract Background Diastolic dysfunction with elevated end-diastolic pressures is a key component of Fontan circulatory failure. However, conventional echocardiographic parameters diastolic function do not correlate invasive in patients. Natural shear waves (SW) are emerging as novel parameter myocardial stiffness, determinant function. Purpose We investigated the relationship between natural SW velocities and Methods patients were prospectively recruited from single center. They underwent...