A5027669473- Cardiovascular Function and Risk Factors
- Cardiovascular and exercise physiology
- Pulmonary Hypertension Research and Treatments
- Cardiovascular Effects of Exercise
- Heart Failure Treatment and Management
- Cardiac Imaging and Diagnostics
- Hemodynamic Monitoring and Therapy
- Cardiac Valve Diseases and Treatments
- Congenital Heart Disease Studies
- Viral Infections and Immunology Research
- Cardiovascular Health and Disease Prevention
- Cardiac Health and Mental Health
- Heart Rate Variability and Autonomic Control
- Ultrasound in Clinical Applications
- Cardiovascular Disease and Adiposity
- Prostate Cancer Diagnosis and Treatment
- Body Composition Measurement Techniques
- Mechanical Circulatory Support Devices
- Respiratory Support and Mechanisms
- Optical Imaging and Spectroscopy Techniques
- Cannabis and Cannabinoid Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Autoimmune and Inflammatory Disorders Research
- Urinary and Genital Oncology Studies
- Aortic Disease and Treatment Approaches
KU Leuven
2017-2025
Hasselt University
2022-2025
Hartcentrum Hasselt
2025
Catholic University of America
2025
Jessa Hospital
2023-2024
Vrije Universiteit Brussel
2024
Ziekenhuis Oost-Limburg
2024
Universitair Ziekenhuis Leuven
2023-2024
Abstract Background Global longitudinal strain (GLS) derived from two-dimensional speckle-tracking echocardiography is feasible and accurate. However, in 2013, the landmark first Inter-Vendor Comparison Study showed significant differences of GLS results among vendors, providing a baseline for ongoing standardization efforts. In order to make tracking-based imaging clinically accepted useful parameter, it utmost importance have interchangeable accurate measurements all vendors. This report...
Recent guidelines redefined exercise pulmonary hypertension as a mean artery pressure/cardiac output (mPAP/CO) slope >3 mm Hg·L
Abstract Background Exercise-induced pulmonary hypertension, characterized by mean artery pressure over cardiac output slope (mPAP/CO slope) > 3mmHg/L/min is associated with worse outcome in greater than moderate primary mitral regurgitation (PMR). However, the prognostic value of right ventricle to coupling (RVPAc) unknown. Purpose Assess RVPAc; determine additional exercise rest RVPAc and compare these findings mPAP/CO slope. Methods The single center study included consecutive...
Abstract Background Pulmonary artery pressure corrected for cardiac output (mPAP/CO) assessed by exercise echocardiography and calculated as the mPAP/CO slope improves risk stratification in various populations. However, it is unclear whether simplified alternatives have a similar predictive ability outcomes. Purpose To evaluate methodology employed to calculate affects prognostic assessment. Methods This secondary analysis of multicenter cohort study that included patients with unexplained...
Abstract Background According to the Fick equation, oxygen uptake (VO2) equals product of cardiac output (CO) and arteriovenous difference (a-vO2Diff). Cardiopulmonary exercise testing (CPET) provides pulse (O2pulse) as ratio VO2 heart rate. The O2pulse is often considered a surrogate for stroke volume (SV) during effort, ignoring AVO2Diff, assess hemodynamic response exercise. Purpose To compare SV measured independently by simultaneous CPET echocardiography (CPETecho). Methods Observation...
Receiver operating characteristics (ROC) curves comparing the ability of value th2/th1 on Day0, Day3, Day7 as well change in one week. D3-0, between Day3 and Day0; D7-0, D7-3, Day3. Legend 2 : Figure 4. characteristic
Abstract Mitochondrial dysfunction and endoplasmic reticulum (ER) stress, which activates the unfolded protein response (UPR), mediate critical illness-induced organ failure, often affecting liver. Autophagy is known to alleviate both suppressed or insufficiently activated autophagy in prolonged illness has shown associate with failure. Whether insufficient contributes failure during by these underlying mechanisms incompletely understood. In this study, we investigated whether inability...
Cardiovascular medical devices undergo a large number of pre- and post-market tests before their approval for clinical practice use. Sophisticated cardiovascular simulators can significantly expedite the evaluation process by providing safe controlled environment representing clinically relevant case scenarios. The complex nature system affected severe pathologies inherently intricate patient–device interaction creates need high-fidelity test benches able to reproduce intra- inter-patient...
Women are at greater risk for heart failure with preserved ejection fraction (HFpEF).
Half of patients with heart failure preserved ejection fraction (HFpEF) remain undiagnosed by resting evaluation alone. Therefore, exercise testing is proposed. The diastolic stress test (DST), however, has limited sensitivity. We aimed to determine the clinical significance adding mean pulmonary artery pressure over cardiac output (mPAP/CO) slope DST in suspected HFpEF.
TIPS placement is an effective, possibly life-saving, treatment for complications of portal hypertension. The pressure shift induced by the stent can lead to cardiac decompensation (CD). We investigated incidence CD, possible variables associated with CD and validity Toulouse algorithm risk prediction post-TIPS.
Abstract Aims Low cardiorespiratory fitness (CRF) is associated with functional disability, heart failure and mortality. Left ventricular (LV) end-diastolic volume (LVEDV) has been linked CRF, but its utility as a diagnostic marker of low CRF not tested. Methods This multi-center international cohort examined the relationship between LV size on echocardiography (peak oxygen uptake [peak VO2] from cardiopulmonary exercise testing) in individuals ejection fraction ≥50%. Absolute BSA-indexed...
Abstract Aims Exercise-induced pulmonary hypertension (PH), defined by a mean arterial pressure over cardiac output (mPAP/CO) slope >3 mmHg/L/min, has important diagnostic and prognostic implications. The aim of this study is to investigate the value mPAP/CO in patients with more than moderate primary mitral regurgitation (MR) preserved ejection fraction no or discordant symptoms. Methods results A total 128 consecutive were evaluated exercise echocardiography cardiopulmonary testing....
In clinical practice, the right heart filling status is assessed using respirophasic variation of inferior vena cava (IVC) by transthoracic echocardiography (TTE) showing moderate correlations with catheter-based reference standard.
Abstract Background and Aims The goal of the present study was to systematically evaluate effect a booster vaccination with BNT162b2 messenger RNA (mRNA; Pfizer‐BioNTech®) vaccine on maximum oxygen uptake (VO 2 max ), potential signs (peri)myocarditis, sports participation. Methods Recreational athletes who were scheduled undergo evaluated transthoracic echocardiography, serum measurements high‐sensitivity C‐reactive protein(hsCRP) troponin I, bicycle cardiopulmonary exercise test (CPET)...
Abstract Background/Introduction Post-exercise ketone supplementation (PEKS) is commonly used in endurance athletes to alleviate overtraining symptoms and stimulate recovery. The introduction of PEKS can blunt the development associated with overtraining, suggesting a potential improvement exercise recovery exercise-induced cardiac adaptations. Although acute nutritional ketosis temporarily improves function at rest healthy individuals heart failure patients, effects on during its relation...
Abstract Background Exercise pulmonary hypertension, defined by a slope of mean artery pressure (mPAP) over cardiac output (CO) >3 mmHg/L/min, measured invasive exercise hemodynamics, is associated with worse event-free survival in patients unexplained dyspnea. Whether non-invasive techniques yield similar results has yet to be tested. Purpose To investigate the prognostic value an mPAP/CO > 3 mmHg/L/min determined echocardiography suspected heart failure preserved ejection...
Abstract Background Exercise-induced pulmonary hypertension (mPAP/CO slope >3mmHg/L/min) was recently associated with worse outcome in >moderate PMR. However, the prognostic value of right ventricle to artery coupling (RVPAc) is unknown. Purpose Assess RVPAc; determine additional exercise over rest RVPAc and compare these findings mPAP/CO slope. Methods Cohort study including consecutive pts submitted CPET-echo PMR, no/discordant symptoms, preserved LV function without...
Abstract Background Cardiorespiratory fitness (CRF) is vital for independent living and a powerful prognostic marker. Increased left ventricular (LV) volume has been linked with high CRF in athletes, but its utility as diagnostic marker of low across the entire health-disease continuum yet to be tested. Methods This multi-center international cohort from Australia Belgium examined relationship between size on resting echocardiography (peakVO2 cardiopulmonary exercise testing [CPET] or CPET...