Anthony Gordon
A5054928970- Sepsis Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
- Hemodynamic Monitoring and Therapy
- COVID-19 Clinical Research Studies
- Respiratory Support and Mechanisms
- Electrolyte and hormonal disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Long-Term Effects of COVID-19
- Cardiac Arrest and Resuscitation
- Nosocomial Infections in ICU
- Adrenal Hormones and Disorders
- Immune Response and Inflammation
- SARS-CoV-2 and COVID-19 Research
- Clinical Reasoning and Diagnostic Skills
- Artificial Intelligence in Healthcare and Education
- Machine Learning in Healthcare
- Meta-analysis and systematic reviews
- Renal function and acid-base balance
- Heart Failure Treatment and Management
- Mechanical Circulatory Support Devices
- Metabolomics and Mass Spectrometry Studies
- Vascular Procedures and Complications
- Pneumonia and Respiratory Infections
- Venous Thromboembolism Diagnosis and Management
- Blood Pressure and Hypertension Studies
National Health Service
2008-2025
Imperial College London
2016-2025
Imperial College Healthcare NHS Trust
2015-2025
Charing Cross Hospital
2011-2023
St Mary's Hospital
2020-2023
Hammersmith Hospital
2022-2023
St. Mary's Hospital
2020-2023
Edwards Lifesciences (United States)
2023
AstraZeneca (India)
2023
Intersurgical (Germany)
2023
The efficacy of interleukin-6 receptor antagonists in critically ill patients with coronavirus disease 2019 (Covid-19) is unclear.We evaluated tocilizumab and sarilumab an ongoing international, multifactorial, adaptive platform trial. Adult Covid-19, within 24 hours after starting organ support the intensive care unit (ICU), were randomly assigned to receive (8 mg per kilogram body weight), (400 mg), or standard (control). primary outcome was respiratory cardiovascular support-free days, on...
Vasopressin is commonly used as an adjunct to catecholamines support blood pressure in refractory septic shock, but its effect on mortality unknown. We hypothesized that low-dose vasopressin compared with norepinephrine would decrease among patients shock who were being treated conventional (catecholamine) vasopressors.In this multicenter, randomized, double-blind trial, we assigned had and receiving a minimum of 5 microg per minute receive either (0.01 0.03 U minute) or (5 15 addition...
Morbidity and mortality for critically ill patients with infections remains a global healthcare problem. We aimed to determine whether β-lactam antibiotic dosing in achieves concentrations associated maximal activity affect patient outcome.This was prospective, multinational pharmacokinetic point-prevalence study including 8 antibiotics. Two blood samples were taken from each during single interval. The primary pharmacokinetic/pharmacodynamic targets free above the minimum inhibitory...
Thrombosis and inflammation may contribute to morbidity mortality among patients with coronavirus disease 2019 (Covid-19). We hypothesized that therapeutic-dose anticoagulation would improve outcomes in critically ill Covid-19.
<h3>Importance</h3> Evidence regarding corticosteroid use for severe coronavirus disease 2019 (COVID-19) is limited. <h3>Objective</h3> To determine whether hydrocortisone improves outcome patients with COVID-19. <h3>Design, Setting, and Participants</h3> An ongoing adaptive platform trial testing multiple interventions within therapeutic domains, example, antiviral agents, corticosteroids, or immunoglobulin. Between March 9 June 17, 2020, 614 adult suspected confirmed COVID-19 were enrolled...
BackgroundEffective targeted therapy for sepsis requires an understanding of the heterogeneity in individual host response to infection. We investigated this by defining interindividual variation transcriptome patients with and related outcome genetic diversity.MethodsWe assayed peripheral blood leucocyte global gene expression a prospective discovery cohort 265 adult admitted UK intensive care units due community-acquired pneumonia evidence organ dysfunction. then validated our findings...
Thrombosis and inflammation may contribute to the risk of death complications among patients with coronavirus disease 2019 (Covid-19). We hypothesized that therapeutic-dose anticoagulation improve outcomes in noncritically ill who are hospitalized Covid-19.In this open-label, adaptive, multiplatform, controlled trial, we randomly assigned were Covid-19 not critically (which was defined as an absence critical care-level organ support at enrollment) receive pragmatically regimens either...
<h3>Importance</h3> Norepinephrine is currently recommended as the first-line vasopressor in septic shock; however, early vasopressin use has been proposed an alternative. <h3>Objective</h3> To compare effect of vs norepinephrine on kidney failure patients with shock. <h3>Design, Setting, and Participants</h3> A factorial (2×2), double-blind, randomized clinical trial conducted 18 general adult intensive care units United Kingdom between February 2013 May 2015, enrolling who had shock...
There is broad interest in improved methods to generate robust evidence regarding best practice, especially settings where patient conditions are heterogenous and require multiple concomitant therapies. Here, we present the rationale design of a large, international trial that combines features adaptive platform trials with pragmatic point-of-care determine treatment strategies for patients admitted an intensive care unit severe community-acquired pneumonia. The uses novel design, entitled...
Levosimendan is a calcium-sensitizing drug with inotropic and other properties that may improve outcomes in patients sepsis.
There remains uncertainty about the role of corticosteroids in sepsis with clear beneficial effects on shock duration, but conflicting survival effects. Two transcriptomic response signatures (SRSs) have been identified. SRS1 is relatively immunosuppressed, whereas SRS2 immunocompetent.We aimed to categorize patients based SRS endotypes determine if these profiles influenced either norepinephrine or vasopressin, septic shock.A post hoc analysis was performed a double-blind, randomized...
<h3>Importance</h3> Vasopressors are commonly administered to intensive care unit (ICU) patients raise blood pressure. Balancing risks and benefits of vasopressors is a challenge, particularly in older patients. <h3>Objective</h3> To determine whether reducing exposure through permissive hypotension (mean arterial pressure [MAP] target, 60-65 mm Hg) reduces mortality at 90 days ICU aged 65 years or with vasodilatory hypotension. <h3>Design, Setting, Participants</h3> A multicenter,...
Heterogeneity in the septic response has hindered efforts to understand pathophysiology and develop targeted therapies. Source of infection, with different causative organisms temporal changes, might influence this heterogeneity.To investigate individual variations transcriptomic sepsis due fecal peritonitis, compare these same parameters community-acquired pneumonia.We performed genome-wide gene expression profiling peripheral blood leukocytes adult patients admitted intensive care...