Sigismond Lasocki
A5030186912- Cardiac, Anesthesia and Surgical Outcomes
- Erythropoietin and Anemia Treatment
- Blood transfusion and management
- Respiratory Support and Mechanisms
- Iron Metabolism and Disorders
- Intensive Care Unit Cognitive Disorders
- Cardiac Arrest and Resuscitation
- Hemoglobinopathies and Related Disorders
- Nosocomial Infections in ICU
- Sepsis Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Antibiotics Pharmacokinetics and Efficacy
- Anesthesia and Pain Management
- Pneumonia and Respiratory Infections
- Antibiotic Use and Resistance
- Hemodynamic Monitoring and Therapy
- Antibiotic Resistance in Bacteria
- Anesthesia and Sedative Agents
- Blood donation and transfusion practices
- Enhanced Recovery After Surgery
- Trauma and Emergency Care Studies
- Airway Management and Intubation Techniques
- Family and Patient Care in Intensive Care Units
- Health, Medicine and Society
Université d'Angers
2016-2025
Centre Hospitalier Universitaire d'Angers
2016-2025
Clinical Trial Investigators
2025
Inserm
2010-2024
Centre National de la Recherche Scientifique
2012-2024
Nantes Université
2022-2024
Imation (United States)
2010-2024
Mitochondrial and Cardiovascular Physiopathology
2017-2024
Université de Strasbourg
2023
Research Network (United States)
2023
Morbidity and mortality for critically ill patients with infections remains a global healthcare problem. We aimed to determine whether β-lactam antibiotic dosing in achieves concentrations associated maximal activity affect patient outcome.This was prospective, multinational pharmacokinetic point-prevalence study including 8 antibiotics. Two blood samples were taken from each during single interval. The primary pharmacokinetic/pharmacodynamic targets free above the minimum inhibitory...
Summary Despite current recommendations on the management of pre‐operative anaemia, there is no pragmatic guidance for diagnosis and anaemia iron deficiency in surgical patients. A number experienced researchers clinicians took part an expert workshop developed following consensus statement. After presentation our own research data local policies procedures, appropriate relevant literature was reviewed discussed. We a series best‐practice evidence‐based statements to advise patient care with...
Preoperative anaemia is common in patients undergoing orthopaedic and other major surgery. Anaemia associated with increased risks of postoperative mortality morbidity, infectious complications, prolonged hospitalization, a greater likelihood allogeneic red blood cell (RBC) transfusion. Evidence the clinical economic disadvantages RBC transfusion treating perioperative has prompted recommendations for its restriction growing interest approaches that rely on patients' own (rather than donor)...
It has not been established whether noninvasive ventilation (NIV) reduces the need for invasive mechanical in patients who develop hypoxemic acute respiratory failure after abdominal surgery.To evaluate improves outcomes among developing surgery.Multicenter, randomized, parallel-group clinical trial conducted between May 2013 and September 2014 20 French intensive care units 293 had undergone surgery developed (partial oxygen pressure <60 mm Hg or saturation [SpO2] ≤90% when breathing room...
The incidence, patient features, risk factors and outcomes of surgery-associated postoperative acute kidney injury (PO-AKI) across different countries health care systems is unclear. We conducted an international prospective, observational, multi-center study in 30 patients undergoing major surgery (> 2-h duration intensive unit (ICU) or high dependency admission). primary endpoint was the occurrence PO-AKI within 72 h defined by Kidney Disease: Improving Global Outcomes (KDIGO) criteria....
BackgroundWhether preventive inhaled antibiotics may reduce the incidence of ventilator-associated pneumonia is unclear.MethodsIn this investigator-initiated, multicenter, double-blind, randomized, controlled, superiority trial, we assigned critically ill adults who had been undergoing invasive mechanical ventilation for at least 72 hours to receive amikacin a dose 20 mg per kilogram ideal body weight once daily or placebo 3 days. The primary outcome was first episode during 28 days...
Before surgery, the best strategy for managing patients who are taking renin-angiotensin system inhibitors (RASIs) (angiotensin-converting enzyme or angiotensin receptor blockers) is unknown. The lack of evidence leads to conflicting guidelines.
Patient blood management (PBM) can prevent preoperative anaemia, but little is known about practice in Europe.To assess the pre and postoperative prevalence perioperative of anaemia patients undergoing elective orthopaedic surgery Europe.An observational study; data were collected from patient records via electronic case report forms.Seventeen centres six European countries. Centres stratified according to whether they had a PBM programme or not.One thousand five hundred thirty-four major...
Patients liberated from invasive mechanical ventilation are at risk of extubation failure, including inability to breathe without a tracheal tube (airway failure) or (non-airway failure). We sought identify respective factors for airway failure and non-airway following extubation.The primary endpoint this prospective, observational, multicenter study in 26 intensive care units was defined as need reintubation within 48 h extubation. A multinomial logistic regression model used...
<h3>Importance</h3> It is not known if use of colloid solutions containing hydroxyethyl starch (HES) to correct for intravascular deficits in high-risk surgical patients either effective or safe. <h3>Objective</h3> To evaluate the effect HES 130/0.4 compared with 0.9% saline volume expansion on mortality and postoperative complications after major abdominal surgery. <h3>Design, Setting, Participants</h3> Multicenter, double-blind, parallel-group, randomized clinical trial 775 adult at...