Yoann Launey
A5068336126- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac Arrest and Resuscitation
- Sepsis Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
- Respiratory Support and Mechanisms
- Nosocomial Infections in ICU
- Mechanical Circulatory Support Devices
- Cerebrospinal fluid and hydrocephalus
- Pneumonia and Respiratory Infections
- Cardiac, Anesthesia and Surgical Outcomes
- Antibiotics Pharmacokinetics and Efficacy
- Antimicrobial Resistance in Staphylococcus
- Liver Disease and Transplantation
- Thermal Regulation in Medicine
- Renal function and acid-base balance
- Blood transfusion and management
- Streptococcal Infections and Treatments
- Frailty in Older Adults
- Appendicitis Diagnosis and Management
- Neurosurgical Procedures and Complications
- Trauma and Emergency Care Studies
- Long-Term Effects of COVID-19
- Central Venous Catheters and Hemodialysis
- Traumatic Brain Injury Research
- Optical Imaging and Spectroscopy Techniques
Centre Hospitalier Universitaire de Rennes
2016-2025
Hôpital Pontchaillou
2015-2024
Université de Rennes
2013-2024
University of Cambridge
2019-2024
Inserm
2012-2023
Centre de recherche en Epidémiologie et Santé des Populations
2023
Université de Versailles Saint-Quentin-en-Yvelines
2023
Centre Hospitalier de Versailles
2023
Société de Réanimation de Langue Française
2022
Société Française d'Allergologie
2021
To test whether the polymyxin B hemoperfusion (PMX HP) fiber column reduces mortality and organ failure in peritonitis-induced septic shock (SS) from abdominal infections. Prospective, multicenter, randomized controlled trial 18 French intensive care units October 2010 to March 2013, enrolling 243 patients with SS within 12 h after emergency surgery for peritonitis related perforation. The PMX HP group received conventional therapy plus two sessions of HP. Primary outcome was on day 28;...
Fluid therapy is an important component of care for patients with traumatic brain injury, but whether it modulates clinical outcomes remains unclear.To determine continuous infusion hypertonic saline solution improves neurological outcome at 6 months in injury.Multicenter randomized trial conducted 9 intensive units France, including 370 moderate to severe injury who were recruited from October 2017 August 2019. Follow-up was completed February 2020.Adult randomly assigned receive 20% plus...
Patients with brain injury are at high risk of extubation failure.We conducted a prospective observational cohort study in four intensive care units three university hospitals. The aim the was to create score that could predict success patients injury.A total 437 consecutive were included, and 338 (77.3%) displayed successful extubation. In multivariate analysis, features associated day extubation: age less than 40 yr, visual pursuit, swallowing attempts, Glasgow coma greater 10. score, each...
The world is currently facing an unprecedented healthcare crisis caused by the COVID-19 pandemic. objective of these guidelines to produce a framework facilitate partial and gradual resumption intervention activity in context group has endeavoured minimum number recommendations highlight strengths be retained 7 predefined areas: (1) protection staff patients; (2) benefit/risk patient information; (3) preoperative assessment decision on intervention; (4) modalities preanaesthesia...
Importance Red blood cell (RBC) transfusion is common among patients admitted to the intensive care unit (ICU). Despite multiple randomized clinical trials of hemoglobin (Hb) thresholds for transfusion, little known about how these are incorporated into current practice. Objective To evaluate and describe ICU RBC practices worldwide. Design, Setting, Participants International, prospective, cohort study that involved 3643 adult from 233 ICUs in 30 countries on 6 continents March 2019 October...
Background Unfractionated heparin, administered during venoarterial extracorporeal membrane oxygenation to prevent thromboembolic events, largely depends on plasma antithrombin for its antithrombotic effects. Decreased heparin responsiveness seems frequent oxygenation; however, association with acquired deficiency is poorly understood. The objective of this study was describe longitudinal changes in levels support and evaluate the between responsiveness. hypothesis that would be associated...
The measurement of ocular nerve sheath diameter (ONSD) via ultrasound scanning is a recent non-invasive method for intracranial pressure (ICP) assessment. Few clinical studies have assessed ONSD variations during osmotherapy the treatment sustained increased ICP episodes. aim our study was to determine rate variation after mannitol administration We consecutively included in prospective, observational study, patients who had severe acute brain injury and monitored with an invasive monitor....
Ischemia is an important pathophysiological mechanism after traumatic brain injury (TBI), but its incidence and spatiotemporal patterns are poorly characterized.To comprehensively characterize the changes in cerebral physiology TBI.This single-center cohort study uses 15oxygen positron emission tomography data obtained a neurosciences critical care unit from February 1998 through July 2014 analyzed April 2018 August 2019. Patients with TBI requiring intracranial pressure monitoring control...
We aimed to determine whether interferon gamma-1b prevents hospital-acquired pneumonia in mechanically ventilated patients. In a multicenter, placebo-controlled, randomized trial conducted 11 European hospitals, we randomly assigned critically ill adults, with one or more acute organ failures, under mechanical ventilation receive (100 µg every 48 h from day 1 9) placebo (following the same regimen). The primary outcome was composite of all-cause mortality on 28. planned sample size 200...
Invasive pulmonary aspergillosis (IPA) in intensive care unit patients is a major concern. Influenza-associated acute respiratory distress syndrome (ARDS) and severe COVID-19 are both at risk of developing invasive fungal diseases. We used the new international definitions influenza-associated (IAPA) COVID-19-associated (CAPA) to compare demographic, clinical, biological, radiological aspects IAPA CAPA monocentric retrospective study. A total 120 were included, 71 with influenza 49 ARDS....
Rebleeding is a major complication in patients admitted for aneurysmal subarachnoid hemorrhage. The optimal timing aneurysm securing after the initial headache remains debated. objective of this study was to evaluate previously established predictive factors rebleeding contemporary retrospective cohort (2020-2022, Rennes University Hospital). Among 226 included analysis, 33 (15%) experienced rebleeding. mean time-to-event (rebleeding or securing) significantly shorter without compared with...
<title>Abstract</title> <bold>Objective</bold> Measuring reliable intracranial pressure (ICP) is critical for patients with acute brain injuries. The aim of this study was to evaluate zero-drift the intra-parenchymal strain gauge Pressio transducer (Sophysa, Orsay, France) in clinical conditions.<bold>Methods</bold> A prospective, observational multicentre conducted 4 French intensive care units (ICU) university hospitals. Patients injuries were included if they needed ICP measurement using...
The French Society of Anaesthesia and Intensive Care Medicine the edited guidelines focused on hospital-acquired pneumonia (HAP) in intensive care unit. goal 16 French-speaking experts was to produce a framework enabling an easier decision-making process for intensivists.The were related 3 specific areas HAP (prevention, diagnosis treatment) 4 identified patient populations (COPD, neutropenia, post-operative paediatric). literature analysis formulation conducted according Grade...
Background & aimsHypophosphatemia (HypoP) is associated with organ dysfunction and mortality. Despite its potential severe consequences, HypoP remains poorly characterized in terms of real prevalence timing onset. The primary objective was to determine the defined as blood phosphate <0.8 < 0.65 mmol/l on one particular day at international level.MethodsOne-day point survey conducted by Section Metabolism, Endocrinology Nutrition (MEN) European Society Intensive Care Medicine (ESICM) during...
Abstract Background Prevalence, risk factors and medical management of persistent pain symptoms after critical care illness have not been thoroughly investigated. Methods We performed a prospective multicentric study in patients with an intensive unit (ICU) length stay ≥ 48 h. The primary outcome was the prevalence significant pain, defined as numeric rating scale (NRS) 3, 3 months admission. Secondary outcomes were compatible neuropathic (ID-pain score > 3) pain. Results Eight hundred...