A5041378932- Pharmacological Effects and Toxicity Studies
- Effects and risks of endocrine disrupting chemicals
- Renal Transplantation Outcomes and Treatments
- Antibiotics Pharmacokinetics and Efficacy
- Toxic Organic Pollutants Impact
- Neurological Complications and Syndromes
- Pharmaceutical Practices and Patient Outcomes
- Antifungal resistance and susceptibility
- Drug Transport and Resistance Mechanisms
- Antimicrobial Resistance in Staphylococcus
- Health, Medicine and Society
- SARS-CoV-2 and COVID-19 Research
- Patient Safety and Medication Errors
- Pneumonia and Respiratory Infections
- Intramuscular injections and effects
- Bipolar Disorder and Treatment
- Pharmaceutical studies and practices
- Fungal Infections and Studies
- Bacterial Identification and Susceptibility Testing
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Diversity and Career in Medicine
- Liver Disease and Transplantation
- SARS-CoV-2 detection and testing
- COVID-19 Clinical Research Studies
- Drug-Induced Hepatotoxicity and Protection
Centre Hospitalier Universitaire de Rennes
2017-2025
Institut de Recherche en Santé, Environnement et Travail
2018-2025
École des Hautes Études en Santé Publique
2018-2025
Inserm
2019-2025
Université de Rennes
2019-2025
CIC Rennes
2025
New York Proton Center
2024
Oregon Medical Research Center
2024
University of Pittsburgh
2024
Communities In Schools of Orange County
2024
Invasive pulmonary aspergillosis (IPA) in intensive care unit patients is a major concern. Influenza-associated acute respiratory distress syndrome (ARDS) and severe COVID-19 are both at risk of developing invasive fungal diseases. We used the new international definitions influenza-associated (IAPA) COVID-19-associated (CAPA) to compare demographic, clinical, biological, radiological aspects IAPA CAPA monocentric retrospective study. A total 120 were included, 71 with influenza 49 ARDS....
Lithium is well recognized as the first-line maintenance treatment for bipolar disorder (BD). However, besides therapeutic benefits attributed to lithium therapy, associated side effects including endocrinological and renal disorders constitute important parameters in prescribing patterns patient adherence. The objectives of this study (i) determine whether long-term therapy with a decrease function, hyperparathyroidism hypercalcemia (ii) identify risk factors lithium-induced chronic kidney...
Abstract Background: Needleless connectors (NCs) can be disinfected using antiseptic barrier caps (ABCs) to reduce the risk of catheter-related bloodstream infections. However, recent evidence suggests that isopropanol leak from ABC into NC, posing concern about their safe use. We sought determine in vitro which and NC parameters influence leakage through infusion circuit. Methods: assessed 13 NCs 4 ABCs available European market. In circuits consisting an cap, a 11-cm catheter line were...
<title>Abstract</title> BackgroundInvasive pulmonary aspergillosis (IPA) in intensive care unit patients is a major concern, particular for those with acute respiratory distress syndrome (ARDS). As observed previously influenza-associated ARDS, the SARS-CoV-2 pandemic has shown high proportion of COVID-19 ARDS to be at risk developing invasive fungal diseases.MethodsWe used new international definitions (IAPA) and COVID-19-associated (CAPA) compare demographic, clinical, biological...
The health safety conditions governing the practice of online hemodiafiltration (OL-HDF) do not yet incorporate risks related to presence endocrine disruptors such as bisphenol A (BPA). aim this study was assess, for first time, exposure BPA but also its chlorinated derivatives (ClxBPA) (100 times more estrogenic than BPA) during OL-HDF. We demonstrated that is transmitted by different medical devices used in OL-HDF: ultrafilters, dialysis concentrate cartridges (and only dialyzers,...
Introduction Women are under-represented in senior academic and hospital positions many countries. The authors aim to assess the place evolution of all appointed female male health practitioners’ working French public Hospitals. Materials methods Data this observational study were collected from National Management Centre (Centre de Gestion) 2015 up January 1, 2020. First, described demographic characteristics specialties medicine, pharmacy, dentistry doctors’ as Hospital Practitioners,...
<h3>Objectives</h3> Given the positive impact of appropriate medication management on graft outcome and therefore patient survival function, pharmacist's role in kidney transplantation team has evolved over recent decades. The primary objective this study was to determine whether pharmacist-led intervention after is associated with a lower rejection rate intra-patient variation tacrolimus trough concentrations (C<sub>min</sub>). study's secondary develop questionnaire identify patients at...
The interactions of six neonicotinoid pesticides and one metabolite with drug transporters have been characterized in vitro. Acetamiprid, clothianidin, imidacloprid, nitenpyram, thiacloprid its amide, thiamethoxam, each used at 100 µM, did not impair activity the efflux pumps P-glycoprotein, multidrug resistance-associated proteins, breast cancer resistance protein. They also inhibit that uptake OATP1B1, OATP1B3, OAT4, MATE1, whereas OATP2B1, OAT1, MATE2-K was affected by only seven...
Evaluate health literacy in transplant patients to better tailor the content of their continuing therapeutic education.
Patients with end stage kidney disease treated by dialysis (ESKDD) process sessions to remove molecules usually excreted kidneys. However, therapy could also contribute endocrine disruptors (ED) burden. Indeed, materials like dialyzer filters, ultrapure dialysate and replacement fluid exposed ESKDD patients Bisphenol A (BPA) chlorinated derivatives of BPA (ClxBPAs). Thus, our aim was compare ClxBPAs exposure between patients, 5 chronic (CKD5) not dialyzed healthy volunteers. Then we describe...
Abstract Background Dexamethasone is commonly used to treat a wide variety of diseases including oncological disorders. The aim this study was propose liquid formulation dexamethasone. Therefore we have developed and assessed the stability 5 mg/mL dexamethasone oral suspension. Methods A stability-indicating analytical method, using HPLC-UV, fully validated according well-recognized international guidelines. suspension prepared acetate powder Ora-Sweet Results mean concentration compounded...
Terbinafine is an antifungaldrug(inhibitor of ergosterol synthesis) known to induce skin reactions. A 58-year-old female was treated with terbinafine for onychomycosis. On the fifth day treatment a rash emerged on her sun-exposed areas. Biological testing did not find any allergic signs. Other reactions are well terbinafine, but we depict here, case photosensitisation induced by treatment, generally unknown this antifungal. This side effect can be prevented medication reconciliation and...
<h3>Objectives</h3> Therapeutic patient education (TPE) plays a critical role in the management of kidney transplant recipients. However, discrepancies exist guidance provided regarding usage immunosuppressants across different centres France. <h3>Methods</h3> To assess current landscape TPE practices this population, an online questionnaire consisting 51 questions was distributed to 32 French renal transplantation centres. <h3>Results</h3> The participation rate our survey 96.9%, (31...