A5018374160- Anesthesia and Pain Management
- Anesthesia and Sedative Agents
- Drug Solubulity and Delivery Systems
- Spine and Intervertebral Disc Pathology
- Antibiotics Pharmacokinetics and Efficacy
- Advanced Drug Delivery Systems
- Pharmaceutical Practices and Patient Outcomes
- Pain Mechanisms and Treatments
- Pharmacogenetics and Drug Metabolism
- Nausea and vomiting management
- Pain Management and Opioid Use
- Veterinary Pharmacology and Anesthesia
- Drug Transport and Resistance Mechanisms
- Pharmaceutical studies and practices
- Neuropeptides and Animal Physiology
- Pharmacological Effects and Toxicity Studies
- Airway Management and Intubation Techniques
- Analytical Methods in Pharmaceuticals
- Sphingolipid Metabolism and Signaling
- Pharmacovigilance and Adverse Drug Reactions
- Pharmacological Receptor Mechanisms and Effects
- Cancer Treatment and Pharmacology
- Metabolism and Genetic Disorders
- Nosocomial Infections in ICU
- Analytical Chemistry and Chromatography
Centre Hospitalier Universitaire de Rennes
2016-2025
Université de Rennes
2016-2025
École des Hautes Études en Santé Publique
2019-2025
Institut de Recherche en Santé, Environnement et Travail
2014-2025
Inserm
1997-2025
Laboratoire de Biophotonique et Pharmacologie
1998-2023
Centre Hospitalier Universitaire de Nantes
2014-2020
Hôpital Pontchaillou
1993-2019
Université de Poitiers
2015
Society for Healthcare Epidemiology of America
2011
The use of topical polymyxin and tobramycin to prevent intensive care infections is controversial. Moreover, these antibiotics are ineffective against methicillin-resistant Staphylococcus aureus. A decontamination regimen using mupirocin chlorhexidine could acquired infections, including those involving S. Because two regimens have a complementary role, we evaluated their effects when given both alone combined.The authors conducted multiple-center, placebo-controlled, randomized,...
The resting cerebrospinal fluid (CSF) norepinephrine concentration is unchanged or even increased in patients with Alzheimer's disease (AD). These vivo findings appear to be inconsistent the post-mortem locus ceruleus neuronal loss that reported AD.The effects of AD and advanced age on central nervous system noradrenergic status were estimated by comparing CSF concentrations following administration yohimbine hydrochloride, clonidine placebo outpatients older young normal subjects. Levels...
Letermovir, a cytomegalovirus prophylactic agent, is widely used in allogeneic HSCT recipients. As an inhibitor of cytochrome P450 3A4 (CYP3A4) and P-glycoprotein (P-gp), it may interact with ciclosporin A (CsA), potentially impacting its pharmacokinetics. Inflammation can impair CYP3A-mediated drug metabolism, severe inflammation reducing CsA metabolism. However, current data on the drug-drug interaction (DDI) between letermovir as perpetrator are limited to healthy volunteers lack...
Background The effects of volume and baricity spinal bupivacaine on block onset, height, duration, hemodynamics were studied. Methods Ninety patients undergoing endoscopic urologic procedures randomized to receive 10 mg intrathecal at L2-L3 level in sitting position. In the operating room, commercial products diluted as needed with NaCl 0.9% obtain isobaric solutions (density, 1.005-1.008) or NaC 10.9% glucose 30% hyperbaric 1.031-1.037) 2, 5, ml (six groups 15 each). Three minutes after...
We sought to evaluate the effect of filling an endotracheal tube cuff with 40 mg lidocaine alone (Group L) or alkalinized LB) in comparison Air Control group C) on adverse emergence phenomena a randomized controlled study (n = 25 each group). The incidence sore throat was decreased for Group LB L during 24 postextubation hours. difference between and C remained significant two hours only. Plasma levels increased when (Cmax were 62.5 ± 34.0 ng/mL 3.2 1.0 Groups L, respectively). Cough...
In Brief When alkalinized lidocaine instead of air is used to fill the endotracheal tube (ETT) cuff, coughing, and bucking are decreased during extubation when ventilation controlled with N2O. However, sodium bicarbonate (NaHCO3) transform hydrochloride (L-HCl) base induces a pH increase that could be irritating for mucosa in case cuff rupture. Therefore, we determined, randomized study patient without N2O, whether smallest concentrations NaHCO3 (1.4% versus 8.4%) reduced diffusion (in vitro...
Given the current scarcity of curative treatment COVID-19, search for an effective modality among all available medications has become a priority. This study aimed at investigating role functional inhibitors acid sphingomyelinase (FIASMAs) on in-hospital COVID-19 mortality. In this retrospective cohort study, we included adult in-patients with laboratory-confirmed between 1 March 2020 and 31 August definite outcomes (discharged hospital or deceased) from Erasme Hospital (Brussels, Belgium)....
Poly(D, L)lactide and polylactide-co-glycolide drug-loaded microspheres were prepared with lipophilic (bupivacaine etidocaine) hydrophilic (mepivacaine lidocaine) local anaesthetics. Formulations of characterized by the drug content, in-vitro release kinetics physical state within microspheres. Release rates anaesthetics from different could not be accounted for intrinsic dissolution drugs. The encapsulation efficiency was highly dependent on lipophilicity drugs, reaching maximum drugs...
We sought to evaluate the effect of filling an endotracheal tube cuff with 40 mg lidocaine alone (Group L) or alkalinized LB) in comparison Air Control group C) on adverse emergence phenomena a randomized controlled study (n = 25 each group). The incidence sore throat was decreased for Group LB L during 24 postextubation hours. difference between and C remained significant two hours only. Plasma levels increased when (Cmax were 62.5 ± 34.0 ng/mL 3.2 1.0 Groups L, respectively). Cough...
Background Ropivacaine is available for spinal or intrathecal use in humans, although data on neurotoxicity after injection are not yet available. The authors experimentally determined the relationship between doses of ropivacaine and effects local neurotoxic effects. Methods Eighty rabbits equipped with an lumbar catheter were studied. Sixty randomly assigned to receive 0.2 ml solutions as a sole of: 0.2%, 0.75%, 1.0%, 2.0% (doses from 0.4-4.0 mg; groups R0.2 R2.0), 5.0% lidocaine (10 group...
Background α2-Adrenergic blockade responses suggest adrenergic dysfunction in hypertension. α2-Blockade is also used to treat autonomic dysfunction. However, pharmacokinetic determinants of yohimbine disposition are not understood. Methods We evaluated α2-blockade with intravenous 172 individuals. Specific cytochrome P450 (CYP) isoform–mediated metabolism was investigated. Results were by ANOVA and maximum likelihood analysis for bimodality response distributions. Yohimbine...