A5004360882- Anesthesia and Pain Management
- Anesthesia and Sedative Agents
- Pain Mechanisms and Treatments
- Nausea and vomiting management
- Cardiac, Anesthesia and Surgical Outcomes
- Pain Management and Opioid Use
- Spine and Intervertebral Disc Pathology
- Airway Management and Intubation Techniques
- Neuropeptides and Animal Physiology
- Intraocular Surgery and Lenses
- Orthopedic Surgery and Rehabilitation
- Veterinary Pharmacology and Anesthesia
- Pain Management and Treatment
- Intraoperative Neuromonitoring and Anesthetic Effects
- Pain Management and Placebo Effect
- Cancer Treatment and Pharmacology
- Shoulder Injury and Treatment
- Musculoskeletal pain and rehabilitation
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Traumatic Brain Injury and Neurovascular Disturbances
- Muscle and Compartmental Disorders
- Thermal Regulation in Medicine
- Dental Anxiety and Anesthesia Techniques
- Respiratory Support and Mechanisms
- Foreign Body Medical Cases
Centre Hospitalier Universitaire de Rennes
2008-2022
Université de Rennes
2007-2020
University of Leeds
2020
Université Claude Bernard Lyon 1
2020
Hôpital Pontchaillou
1995-2020
Université Libre de Bruxelles
2020
Centre Hospitalier Universitaire de Saint-Pierre
2020
Institut de Recherche en Santé, Environnement et Travail
2017
Inserm
2015
Université de Poitiers
2015
This study examines the relationship between pneumatic tourniquet cuff size, occlusion pressure and resulting pain. Two widths were used, a wide (14 cm) narrow (7 cm). Twenty volunteers divided into two groups for application: group in which was inflated to equal systolic + 100 mmHg, saturation 10 mmHg above loss of arterial pulse, as indicated by cessation pulse waveform on an oximeter. According randomised cross‐over protocol, subjects studied using cuffs simultaneously and/or successively...
Nowadays, ultrasound-guidance is commonly used in regional anaesthesia (USGRA) and to locate the spinal anatomy neuraxial analgesia. The aim of this second guideline on PERi-operative uSE UltraSound (PERSEUS-RA) provide evidence as which areas use ultrasound guidance should be considered a gold standard or beneficial patient. PERSEUS Taskforce members were asked define relevant outcomes rank relative importance following GRADE process. Whenever literature was not able enough evidence, we...
Amitriptyline is a tricyclic antidepressant drug used systemically for the management of neuropathic pain. Antidepressants, as class drugs with direct neurologic actions, are becoming widely chronic pain, although their mechanisms not entirely understood. exerts potent effects on reuptake norepinephrine and serotonin blocks alpha 2A adrenoreceptors N-methyl-D-aspartate receptors. Because amitriptyline also particularly blocker sodium channels voltage-gated potassium calcium channels, it has...
We studied the inhibition of peroxidation by local anesthetics in an inflammatory animal model. Inflammatory lipid was assessed thiobarbituric assay plasma from rats injected or not with carrageenan (Carra) and killed 1, 2, 4, 6, 12, 24 h thereafter. Thiobarbituric acid reactive substances (TBARS) values animals were maximal 6 after Carra administration. This result, accordance evolution paw edema width during time, supports that TBARS reflect intensity inflammation. Local (bupivacaine,...
In Brief BACKGROUND: Ropivacaine is used by the epidural route for postoperative pain management with various neuraxial techniques. Given widespread use of these techniques and relative paucity data on spinal disposition local anesthetics, we evaluated through an experimental animal model, ropivacaine, allowing further studies factors influencing their intrathecal bioavailability. METHODS: Sheep received IV bolus dose ropivacaine (50 mg), 1 wk after, (20 mg) followed 3 h later (100 mg). A...
BACKGROUND The effect of dexmedetomidine on Nociception Level Index-guided (Medasense, Israel) antinociception to reduce intra-operative opioid requirements has not been previously investigated. OBJECTIVE We aimed determine if low-dose would remifentanil during without increasing complications associated with dexmedetomidine. DESIGN Double-blind randomised controlled trial. SETTING Two university teaching hospitals in Brussels, Belgium. PATIENTS American Society Anesthesiologists 1 and 2...
We evaluated bupivacaine-loaded microspheres (B-Ms) using a brachial plexus block model in sheep. In the first step, pharmacokinetic characterization of 75 mg bupivacaine hydrochloride (B-HCl) (IV infusion and block) was performed (n = 12). second dose response study B-HCl with 37.5 mg, 150 300 750 mg. As comparison, evaluations were 750-mg base (B). third B-Ms (750 B as B-Ms) two formulations, 60/40 50/50 (w/w %); drug-free also evaluated. Toxicity after IV administration mg), (30 mL over 1...
LABORATORY animal studies are necessary models for the assessment of new drugs and/or drug delivery system used in regional anesthesia. 1–3Few data reported literature, excepted sciatic nerve blockade rats. Therefore, aim this study was to evaluate approach brachial plexus block a sheep model using bupivacaine.Sheep were chosen because they comparable size and weight humans. Veterinary literature on studied determine landmarks perform comparison 4Sheep have postfixed (C6–T2), whereas humans...
<h3>Background and Objectives:</h3> Neural blockade techniques are associated with a risk of acute cardiac toxicity after accidental intravenous (IV) injection local anesthetics. The aim this study was to compare electrocardiographic (ECG) hemodynamic (HEM) effects induced by IV infusion anesthetics in an anesthetized ewe model. <h3>Methods:</h3> Thirty-two ewes received bupivacaine (BUPI), ropivacaine (ROPI), or levobupivacaine (S-BUPI) at equimolar dose, lidocaine (LIDO) 3-fold higher rate...
We evaluated bupivacaine-loaded microspheres (B-Ms) using a brachial plexus block model in sheep. In the first step, pharmacokinetic characterization of 75 mg bupivacaine hydrochloride (B-HCl) (IV infusion and block) was performed (n = 12). second dose response study B-HCl with 37.5 mg, 150 300 750 mg. As comparison, evaluations were 750-mg base (B). third B-Ms (750 B as B-Ms) two formulations, 60/40 50/50 (w/w %); drug-free also evaluated. Toxicity after IV administration mg), (30 mL over 1...
There is considerable interest in developing a sustained-release local anesthetic formulation to provide long-lasting anesthesia and decrease systemic toxicity. Bupivacaine (B), 10 mg, loaded two different types of polylactide microspheres (PLA1 PLA2) was evaluated after spinal injection compared with plain bupivacaine (pB), 2 mg. Experiments were performed six New Zealand rabbits. Duration motor block significantly prolonged for PLA1 pB (177.5 +/- 79.5 min vs 44.6 18.0 min; P < 0.05), as...