P Guinet

ORCID: 0009-0007-3775-7081
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About
Contact & Profiles
Research Areas
  • Thyroid Cancer Diagnosis and Treatment
  • Thyroid Disorders and Treatments
  • Pituitary Gland Disorders and Treatments
  • Medical and Biological Sciences
  • Adrenal and Paraganglionic Tumors
  • Sexual Differentiation and Disorders
  • Adrenal Hormones and Disorders
  • Hormonal and reproductive studies
  • Bone health and treatments
  • Spaceflight effects on biology
  • Medical Imaging and Pathology Studies
  • Metabolism and Genetic Disorders
  • High Altitude and Hypoxia
  • Cardiovascular and Diving-Related Complications
  • Diet and metabolism studies
  • Neurological and metabolic disorders
  • Growth Hormone and Insulin-like Growth Factors
  • Ophthalmology and Eye Disorders
  • Thyroid and Parathyroid Surgery
  • Hemodynamic Monitoring and Therapy
  • Male Breast Health Studies
  • Electrolyte and hormonal disorders
  • Cancer, Hypoxia, and Metabolism
  • Cardiac, Anesthesia and Surgical Outcomes
  • Genetic Neurodegenerative Diseases

Muséum national d'Histoire naturelle
2025

Centre Hospitalier Universitaire de Rennes
2017-2020

Centre Hospitalier de Fougères
2020

Université de Rennes
2006-2019

Hôpital Pontchaillou
2010-2018

Inserm
2006-2009

University of California, San Diego
2006-2008

Johnson Space Center
2008

<h3>Importance</h3> Low cardiac output syndrome after surgery is associated with high morbidity and mortality in patients impaired left ventricular function. <h3>Objective</h3> To assess the ability of preoperative levosimendan to prevent postoperative low syndrome. <h3>Design, Setting, Participants</h3> Randomized, double-blind, placebo-controlled trial conducted 13 French surgical centers. Patients a ejection fraction less than or equal 40% scheduled for isolated combined coronary artery...

10.1001/jama.2017.9973 article EN JAMA 2017-08-08

Cardiovascular deconditioning after long duration spaceflight is especially challenging in women who have a lower orthostatic tolerance (OT) compared with men. We hypothesized that an exercise prescription, combining supine aerobic treadmill body negative pressure (LBNP) chamber followed by 10 min of resting LBNP, three to four times week, and flywheel resistive training every third day would maintain during 60-day head-down-tilt bed rest (HDBR). Sixteen were assigned two groups (exercise,...

10.1007/s00421-009-1009-6 article EN cc-by-nc European Journal of Applied Physiology 2009-02-26

Abstract Long‐term biodiversity monitoring is needed to track progress towards ambitious global targets reduce species loss and restore ecosystems. The recent development of cheap robust acoustic recording devices offers a cost‐effective means gathering standardised long‐term datasets. Accounting for sources bias in ecological research fundamental part the study design process. To highlight this issue context terrestrial ecoacoustic monitoring, here we collate discuss arising from (i)...

10.1111/1365-2664.70000 article EN cc-by Journal of Applied Ecology 2025-02-14

To address the safety (rate of thromboembolic events and circuit complications) efficacy bleeding control) recombinant activated coagulation factor VII (rFVIIa) to treat severe refractory all surgical medical treatments in patients under veno-arterial (VA) or veno-venous (VV) extracorporeal membrane oxygenation (ECMO) support.In a tertiary referral University Cardiothoracic Surgery Centre including three intensive care units, 30 received rFVIIa during ongoing VA VV ECMO support (8.6%...

10.1093/ejcts/ezv140 article EN European Journal of Cardio-Thoracic Surgery 2015-04-23

Abstract Introduction Microcirculatory blood flow, and notably gut perfusion, is important in the development of multiple organ failure septic shock. We compared effects dopexamine norepinephrine (noradrenaline) with those epinephrine (adrenaline) on gastric mucosal flow (GMBF) patients The these drugs oxidative stress were also assessed. Methods This was a prospective randomized study performed surgical intensive care unit among adults fulfilling usual criteria for Systemic pulmonary...

10.1186/cc4827 article EN cc-by Critical Care 2006-02-16

<h3>Background and Objectives:</h3> Neural blockade techniques are associated with a risk of acute cardiac toxicity after accidental intravenous (IV) injection local anesthetics. The aim this study was to compare electrocardiographic (ECG) hemodynamic (HEM) effects induced by IV infusion anesthetics in an anesthetized ewe model. <h3>Methods:</h3> Thirty-two ewes received bupivacaine (BUPI), ropivacaine (ROPI), or levobupivacaine (S-BUPI) at equimolar dose, lidocaine (LIDO) 3-fold higher rate...

10.1097/aap.0b013e31819338e2 article EN Regional Anesthesia & Pain Medicine 2009-01-01

Head-down bed rest (HDBR) is commonly considered as ground-based analog to spaceflight and simulates the headward fluid shift cardiovascular deconditioning associated with spaceflight. We investigated in healthy volunteers whether HDBR, or without countermeasures, affect cerebral autoregulation (CA). Twelve men (at selection: 34±7 years; 176±7 cm; 70±7 kg) underwent three interventions of a 21-day HDBR: control condition countermeasure (CON), resistance vibration exercise (RVE) comprising...

10.3389/fphys.2019.01114 article EN cc-by Frontiers in Physiology 2019-08-27

Current inflight countermeasures do not completely prevent bone and cardiovascular changes induced by microgravity. High load Resistance Exercise combined with whole body Vibration (RVE) demonstrated benefits on system during previous Head Down Bed Rest (HDBR) studies. We examined the effectiveness of RVE alone or a nutritional supplementation Whey protein (NeX) deconditioning. Eight male subjects (age 34 ± 8 year) in crossover design completed three 21-day HDBR campaigns (Control-CON, NeX)....

10.3389/fphys.2020.00812 article EN cc-by Frontiers in Physiology 2020-07-16

The relation between benign and malignant growth is not academic.If a process can really arise within the capsule of tumour, enucleation tumour should be suitable method prevention.But if, on contrary, cancer occurs round nodule more radical treatment indicated.Controversy especially sharp in case thyroid gland, as has been remarked by Brenizer McKnight (1940).A clinician's opinion about degenera- tion goitre may quite different from that pathologist.It generally admitted Europe Swiss...

10.1136/bmj.2.4794.1122 article EN BMJ 1952-11-22
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