A5014693325- Spaceflight effects on biology
- Heart Rate Variability and Autonomic Control
- High Altitude and Hypoxia
- Thermoregulation and physiological responses
- Cardiovascular and exercise physiology
- Muscle metabolism and nutrition
- Body Composition Measurement Techniques
- Climate Change and Health Impacts
- Birth, Development, and Health
- Cardiovascular Syncope and Autonomic Disorders
- Cardiovascular Health and Disease Prevention
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Nitric Oxide and Endothelin Effects
- Musculoskeletal pain and rehabilitation
- Transcranial Magnetic Stimulation Studies
- Muscle activation and electromyography studies
- Advanced Proteomics Techniques and Applications
- Bone health and osteoporosis research
- Hydrogen's biological and therapeutic effects
- Hemodynamic Monitoring and Therapy
- Non-Invasive Vital Sign Monitoring
- Cardiac electrophysiology and arrhythmias
- Space Exploration and Technology
- Vitamin D Research Studies
Centre Hospitalier Universitaire d'Angers
2015-2024
Université d'Angers
2015-2024
Inserm
2014-2024
Centre National de la Recherche Scientifique
2014-2024
Université Rennes 2
2024
European Space Agency
2024
Université de Rennes
2024
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2024
University of Antwerp
2024
Mitochondrial and Cardiovascular Physiopathology
2022
A sedentary lifestyle has adverse effects on the cardiovascular system, including impaired endothelial functions. Subjecting healthy men to 7 days of dry immersion (DI) presented a unique opportunity analyze specific enhanced inactivity endothelium. We investigated properties before, during, and after DI involving eight subjects. Microcirculatory functions were assessed with laser Doppler in skin calf. studied basal blood flow endothelium-dependent -independent vasodilation. also measured...
Sedentary behavior has deleterious effects on the cardiovascular system, including reduced endothelial functions. A 2-mo bed rest study in healthy women [women international space simulation for exploration (WISE) 2005 program] presented a unique opportunity to analyze specific of prolonged inactivity without other vascular risk factors endothelium. We investigated properties before and after 56 days 8 subjects who performed no exercise (control group: No-EX) regularly treadmill lower body...
To determine whether hydroxychloroquine decreases the risk of adverse outcome in patients with mild to moderate coronavirus disease 2019 (COVID-19) at high worsening.We conducted a multicentre randomized double-blind placebo-controlled trial evaluating COVID-19 least one following factors for worsening: need supplemental oxygen, age ≥75 years, between 60 and 74 years presence co-morbidity. Severely ill requiring oxygen therapy >3 L/min or intensive care were excluded. Eligible 1:1 ratio...
Objective Estimating the risk entailed by classical factors like blood pressure (BP) or serum cholesterol may be difficult because of their variability and often unknown duration exposure. Having variables integrating impact those on cardiovascular system would probably aid prediction events. The present study aimed at determining whether cardiac baroreflex sensitivity (BRS), correlates with several thus is a good candidate for being such an integrative variable. As comparison, left...
To determine the change in intraocular pressure (IOP) due to postural changes young healthy volunteers.Intraocular was measured using a calibrated Pulsair noncontact tonometer both eyes of 25 female volunteers sitting position and after 1, 3, 10 minutes supine position. In second part experiment (a 7-day -6 degrees head-down tilt [HDT]), IOP (at 8 am, 12 am 6 pm) corneal thickness (12 am) were monitored before, during, HDT period. Blood pressure, hematocrit, plasma volume osmolality,...
Confinement experiments are essential to prepare long-term space exploration. The 180-day Chinese CELSS (Controlled Ecological Life Support System) study is unique in its design, including a closed-loop system and mid-mission simulation of Mars-like day-night cycle 24 h 40 min for 36 days (days 72-108). Our aim was physiological psychological consequences this confinement four healthy volunteers (one female). platform consisted six interconnected modules greenhouses. support systems were...
Dry immersion (DI) is a Russian-developed, ground-based model to study the physiological effects of microgravity. It accurately reproduces environmental conditions weightlessness, such as enhanced physical inactivity, suppression hydrostatic pressure and supportlessness. We aimed integrative responses 3-day strict dry protocol in 12 healthy men, assess extent multi-system deconditioning. recorded general clinical data, biological data evaluated body fluid changes. Cardiovascular...
Background. The most applicable human models of weightlessness are Head-Down Bed Rest (HDBR) and Dry Immersion (DI). However, a detailed comparison the was not carried out. Objectives. We compared changes in central hemodynamics, autonomic regulation, plasma volume water balance induced by HDBR DI. Methods. 11 subjects participated 21-day HDBR, 12 – 3-day During exposure, (the difference between intake diuresis), blood pressure heart rate were registered daily. Plasma evolution estimated...
The aim of the study was to compare proteomic data on effects spaceflight factors human body, including both real space missions and ground-based experiments. LC-MS/MS-based analysis blood plasma samples obtained from 13 cosmonauts before after long-duration (169-199 days) International Space Station (ISS) for five healthy men included in 21-day-long head-down bed rest (HDBR) dry immersion experiments were performed. semi-quantitative label-free revealed significantly changed proteins: 19...
Background:The relative stability of cerebral blood flow is maintained by the baroreflex and autoregulation (CA). We assessed relationship between sensitivity (BRS) CA in patients with atherosclerotic carotid stenosis or occlusion.Methods Results:Patients referred for assessment unilateral >50% occlusion were included. Ten healthy volunteers served as a reference group. BRS was measured using sequence method. quantified correlation coefficient (Mx) slow oscillations mean arterial pressure...
Human locomotion is a complex sensorimotor behavior whose central control remains difficult to explore using neuroimaging method due technical constraints, notably the impossibility walk with scanner on head and/or for real inside current scanners. The aim of this functional Magnetic Resonance Imaging (fMRI) study was analyze interactions between two paradigms investigate brain gait network: (1) mental imagery gait, and (2) passive mechanical stimulation plantar surface foot Korvit boots....
Background Dry immersion (DI), a ground-based model of microgravity previously used in Russia, has been recently implemented France. The aim this study was to analyze early events short-term DI which all conditions are met investigate who is first challenged from osteo- or adipo-kines and what extent they associated insulin-regulating hormones. Methods Twelve healthy men were submitted 3-day DI. Fasting blood collected during pre-immersion phase for the determination baseline data collection...
The objective of the study was to determine influence simulated microgravity by exposure dry immersion on craniomandibular system. Twelve healthy male volunteers participated in a 3-day study. Before and immediately after we measured maximal bite force using piezoresistive sensors. mechanical properties jaw cervical muscles were evaluated before, during, MyotonPRO. Because recent studies reported effects motor activity postural stability humans, stabilometric measurements center pressure...
Increased renal resistive index (RI) measured by Doppler ultrasonography has been shown to be associated with acute kidney injury (AKI) in septic patients. However, its clinical use is limited poor sensitivity and specificity which may explained numerous determinants [in particular mean arterial pressure (MAP)]. We measured, patients shock, RI at different MAP levels over a short period of time on the admission day ICU (D1) every 3 days until 10 (D10) define study specifically relationship...
Astronauts in microgravity experience multi-system deconditioning, impacting their inflight efficiency and inducing dysfunctions upon return to Earth gravity. To fill the sex gap of knowledge health impact spaceflights, we simulate with a 5-day dry immersion 18 healthy women (ClinicalTrials.gov Identifier: NCT05043974). Here show that rapidly induces sedentarily-like metabolism shift mimicking beginning metabolic syndrome drop glucose tolerance, an increase atherogenic index plasma, impaired...
The most accepted animal model for simulation of the physiological and morphological consequences microgravity on cardiovascular system is one head-down hindlimb unloading. Experimental conditions surrounding this include not only tilting rats, but also social restraint stresses that have their own influences function. Here, we studied levels spontaneous locomotor activity, blood pressure, heart rate during 14 days under following experimental conditions: cage control, isolation in standard...
Dry immersion (DI) is used to simulate weightlessness. We investigated in healthy volunteers if DI induces changes ONSD, as a surrogate marker of intracranial pressure (ICP) and how these could affect cerebral autoregulation (CA). Changes ICP were indirectly measured by optic nerve sheath diameter (ONSD). 12 male underwent 3 days DI. ONSD was assessed ocular ultrasonography. Cerebral blood flow velocity (CBFV) the middle artery gauged using transcranial Doppler CA evaluated two methods: 1)...
Urinary proteins serve as indicators of various conditions in human normal physiology and disease pathology. Using mass spectrometry proteome analysis, the permanent constituent urine was examined Mars-500 experiment (520 days isolation healthy volunteers a terrestrial complex with an autonomous life support system). Seven predominant distribution liver blood plasma well extracellular localization were identified. Analysis overrepresentation molecular functions biological processes based on...
The objective of this study was to investigate plasma volume (PV), total body water, hormones and hydroelectrolyte responses in eight males (25–40 years) females (25–31 during 7 days exposure simulated microgravity (–6° head‐down bed rest, HDBR). Bed rest is a model that has commonly been used simulate spaceflight. Heart rate (HR), blood pressure (BP) vasoactive hormone were studied before after HDBR 10‐min stand test. No change water mass noted either sex. decrease PV similar both men (9·1...
Angiotensin II is a potent growth factor involved in arterial wall homeostasis. In resistance arteries, chronic increases blood flow induce rise diameter associated with hypertrophy. Nevertheless, the role of angiotensin this remodeling unknown. We investigated effect blocking production or receptor activation on flow-induced mesenteric arteries. Arteries were ligated vivo to generate high-flow arteries compared normal (control) vessels located at distance. isolated after 1 week for vitro...