A5032783509- Spaceflight effects on biology
- High Altitude and Hypoxia
- Muscle metabolism and nutrition
- Heart Rate Variability and Autonomic Control
- Human Health and Disease
- Thermoregulation and physiological responses
- Advanced Proteomics Techniques and Applications
- Health, Environment, Cognitive Aging
- Cardiovascular and Diving-Related Complications
- Air Quality and Health Impacts
- Biochemical effects in animals
- Sodium Intake and Health
- Metabolomics and Mass Spectrometry Studies
- Heat shock proteins research
- Climate Change and Health Impacts
- Cardiovascular Health and Risk Factors
- Circadian rhythm and melatonin
- Electromagnetic Fields and Biological Effects
- Exercise and Physiological Responses
- Diet and metabolism studies
- Medical and Biological Ozone Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Nutritional Studies and Diet
- Chronic Kidney Disease and Diabetes
- Chronic Obstructive Pulmonary Disease (COPD) Research
Institute of Biomedical Problems
2016-2024
Skolkovo Institute of Science and Technology
2022
The process of aging is intimately linked to alterations at the tissue and cellular levels. Currently, role senescent cells in microenvironment still being investigated. Despite common characteristics, different cell populations undergo distinctive morphofunctional changes during senescence. Mesenchymal stem (MSCs) play a pivotal maintaining homeostasis. A multitude studies have examined cytokine profile that determine their regulatory function. extracellular matrix (ECM) MSCs less studied...
Investigations of differentially regulated molecular characteristics based on the results panoramic profiling bacterial cell lysate proteomes using chromatography-mass spectrometry and gene ontology analysis, identification enzymes involved in metabolic activity modification strains cultivated a hypomagnetic environment (HME) displayed dissimilar effects epidermal staphylococci S1 S3. Nonetheless, responses certain properties are alike. Both enlarged individual urease subunits (in S3, this...
The aim of the study was to compare proteomic data on effects spaceflight factors human body, including both real space missions and ground-based experiments. LC-MS/MS-based analysis blood plasma samples obtained from 13 cosmonauts before after long-duration (169-199 days) International Space Station (ISS) for five healthy men included in 21-day-long head-down bed rest (HDBR) dry immersion experiments were performed. semi-quantitative label-free revealed significantly changed proteins: 19...
Primary focal segmental glomerulosclerosis (FSGS), along with minimal change disease (MCD), are diseases primary podocyte damage that clinically manifested by the nephrotic syndrome. The pathogenesis of these podocytopathies is still unknown, and therefore, search for biomarkers ongoing. Our aim was to determine proteomic profile urine from patients FSGS MCD. Patients a confirmed diagnosis (n = 30) MCD 9) were recruited study. For comprehensive assessment severity special index introduced,...
Introduction: Spaceflight is one of the most extreme conditions encountered by humans: Individuals are exposed to radiation, microgravity, hypodynamia, and will experience isolation. A better understanding molecular processes induced these factors may allow us develop personalized countermeasures minimize risks astronauts.Areas covered: This review a summary literature searches from PubMed, NASA, Roskosmos authors' research experiences opinions. The covers available proteomic data on effects...
Head-down bed rest (HDBR) is one of the models physiological effects weightlessness used, among other things, to assess effect hypokinesia on systems human body and, first all, cardiovascular system. The aim work was study 21 days HDBR factors system based blood proteomic profile data. It revealed that conditions led an increase in levels proteins complement and coagulation cascade systems, platelet degranulation, fibrinolysis, acute phase proteins, post-translational modification...
The conditions of space flight have a significant effect on the physiological processes in human body, yet molecular mechanisms driving changes remain unknown. Blood samples 18 Russian cosmonauts who had conducted long-duration missions to International Space Station were collected 30 days before launch and first seventh after landing. A panel 125 proteins blood plasma was quantitated by well-established highly regarded targeted mass spectrometry approach. This method involves monitoring...
The strategy of adaptation the human body in microgravity is largely associated with plasticity cardiovascular system regulatory mechanisms. During long-term space flights changes stroke volume heart are observed, rate decreases, phase structure cardiac cycle readjusted purpose this work was to clarify urine proteome initial condition autonomic regulation mechanisms cosmonauts who have participated long missions. Urine each cosmonaut analyzed before and after flight, depending on parameters...
DATA REPORT article Front. Physiol., 11 January 2022Sec. Environmental, Aviation and Space Physiology Volume 12 - 2021 | https://doi.org/10.3389/fphys.2021.753291
The purpose of the study was to investigate regulatory and metabolic changes in circulatory system when simulating microgravity conditions a five-day dry immersion. These reflect adaptation processes characteristic for initial stages space flight or short-duration flight. Studies were conducted with 13 healthy male volunteers aged 21 29 years. assessment based on heart rate variability (HRV) urine proteomic profile analysis. It found that restructuring hemodynamics during 5 days hypogravity...
DATA REPORT article Front. Physiol., 24 July 2020Sec. Environmental, Aviation and Space Physiology Volume 11 - 2020 | https://doi.org/10.3389/fphys.2020.00678
Specifics of urine proteome is sensitive to a multitude factors. One nutrition or entrance in organism main nutrients including salt (NaCI). Purpose the investigation was study proteomic composition healthy human controlled environment 105-day isolation experiment (project <<Mars-500>>) with various levels intake. Analysis performed using present-day proteomics techniques based on chromatography-mass spectrometry and bio-informatics options. An attempt made correlate changes processes...
<title>Abstract</title> The molecular mechanisms of organismal adaptation to spaceflight (SF) conditions are not fully investigated and remain relevant for study. Newly emerging multi-omics technologies may provide information at the level regarding physiological changes caused by SF factors. aim study was apply blood proteome analysis using dried spots (DBS) micro-sampling technique response 7 cosmonauts during 169–199 days long-duration missions (one participated in a year-long mission)....