A5101974053- Spaceflight effects on biology
- Electromagnetic Fields and Biological Effects
- Thermoregulation and physiological responses
- Heart Rate Variability and Autonomic Control
- Human Health and Disease
- High Altitude and Hypoxia
- T-cell and B-cell Immunology
- Biochemical effects in animals
- Fusion and Plasma Physics Studies
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Cardiovascular and exercise physiology
- Cardiovascular and Diving-Related Complications
- Biomedical Ethics and Regulation
- Technology and Human Factors in Education and Health
- Long-Term Effects of COVID-19
- Space Exploration and Technology
- Biofield Effects and Biophysics
- Inflammasome and immune disorders
- Phytochemistry and Biological Activities
- Cutaneous lymphoproliferative disorders research
- Biotin and Related Studies
- Diet and metabolism studies
- Phytochemistry and Bioactive Compounds
- Salivary Gland Disorders and Functions
Institute of Biomedical Problems
2021-2024
Russian Academy of Sciences
2024
Universidad Autónoma de Madrid
2022-2024
Yandex (Russia)
2024
Hospital Universitario de La Princesa
2022-2023
Czech Academy of Sciences, Institute of Philosophy
2022
Diplomatic Academy of the Russian Foreign Ministry
2022
Abstract Increased recruitment of transitional and non-classical monocytes in the lung during SARS-CoV-2 infection is associated with COVID-19 severity. However, whether specific innate sensors mediate activation or differentiation response to different proteins remain poorly characterized. Here, we show that Spike 1 but not nucleoprotein induce into subsets from both peripheral blood bronchoalveolar lavage samples a NFκB-dependent manner, this process does require inflammasome activation....
Primary Sjögren's syndrome (pSS) is an inflammatory autoimmune disorder largely mediated by type I and II interferon (IFN). The potential contribution of innate immune cells, such as natural killer (NK) cells dendritic (DC), to the pSS pathology remains understudied. Here, we identified enriched CD16+ CD56hi NK cell subset associated with higher cytotoxic function, well elevated proportions CD64+ conventional (cDC2) subtype that expresses increased levels MICa/b, ligand for activating...
The individual contribution of specific myeloid subsets such as CD1c+ conventional DC (cDC) to perpetuation rheumatoid arthritis (RA) pathology remains unclear. In addition, the innate sensors driving pathogenic activation cDC in patients with RA and their functional implications have not been characterized. Here, we assessed phenotypical, transcriptional, characteristics CD141+ monocytes from blood synovial fluid RA. Increased levels CCR2 IgG receptor CD64 on circulating was associated...
Background . Antiorthostatic hypokinesia (ANOH) reproduces some of the effects weightlessness on human body and is used to study adaptation space flight conditions. It known that ANOH affects nighttime sleep, but there no information in literature sequence occurrence sleep disorders ANOH. The aim research was dynamics subjective changes assessing quality under conditions antiorthostatic hypokinesia. Materials methods Six healthy male volunteers (age from 26 34 years) participated experiment...
DATA REPORT article Front. Physiol., 11 January 2022Sec. Environmental, Aviation and Space Physiology Volume 12 - 2021 | https://doi.org/10.3389/fphys.2021.753291
OPINION article Front. Physiol., 12 May 2023Sec. Environmental, Aviation and Space Physiology Volume 14 - 2023 | https://doi.org/10.3389/fphys.2023.1162355
Choice of the best statistical data analysis is core for successful investigation. The paper describes a pattern choosing methods medical with consideration type variables and purpose analysis. proposed way graphic representation proceeds from visualized applied patterns help investigator systematize own knowledge about presentation, use them as an instrument rapid choice appropriate diagrams. Systematization presentation can be useful in course investigations preparation papers scientific...
pyatigorsk medical-pharmaceutical
ВЕГЕТАТИВНАЯ РЕГУЛЯЦИЯ КРОВООБРАЩЕНИЯ И БИОЭЛЕКТРИЧЕСКИЕ ПРОЦЕССЫ В МИОКАРДЕ ЧЕЛОВЕКА УСЛОВИЯХ УМЕНЬШЕНИЯ ГРАВИТАЦИОННОЙ НАГРУЗКИПопова О.В.,
The paper analyzes changes in blood proteome a group of essentially healthy female subjects (30.17 ± 5.5 y.o.) following 3-day dry immersion (DI). Depending on the predominance modulating vegetative effects determined by analysis heart rate variability (HRV), dynamics protein composition was analyzed using dried spot sampling. It demonstrated that period baseline data collection with usual motor activity, energy expenditure provided mainly carbohydrate contributors which, level, varied type...
It is common knowledge that during space missions (SMs) the cosmonauts are subjected to stresses. One of potential SMs problems disorders in bioelectrical parameters myocardium conductivity or arrhythmias. The paper analyzes results investigations into changes cardiac rhythm variability a group 5 (46 ± 4.5 yrs age) using ECG records containing episodes atrial and/or ventricular Mean mission duration each cosmonaut was about six months as standard. Analysis experimental data on occurrence may...
Introduction. Due to the fact that manned space flights beyond Earth orbit are planned in near future, it becomes relevant study effects of Earth’s reduced magnetic field on humans. Objective. To evaluate features sensorimotor reactions, quality night sleep (nocturnal sleep) and development daytime sleepiness during a 24-hour stay under hypomagnetic conditions (HMC). Materials methods. Experimental studies with participation 6 male volunteers aged 26 37 years were conducted 2023. In total,...
The proposal is a complex experiment that had design – double-blind randomized placebo-controlled study. An effective measurement of the parameters human body was examined on 8 apparently healthy subjects during an exposure hours in altered magnetic conditions. results did not reveal significant risks for functional state with decrease multiplicity about 1000 times.
Objective: to study the diagnostic and prognostic value of changes in red blood cell electrophoretic mobility (RBCEM) patients with infectious noninfectious forms intoxication. Materials methods. A cytoferometer (Opton) was used determine RBCEM; venous samples taken on heparin were studied. Thirty peritonitis (infectious intoxication) 22 a pancreatic tumor mechanical jaundice (noninfectious examined. All received standard therapy for this disease. Eight out 30 died days 3—10 postoperatively....
Abstract The toxicological study conducted revealed high concentrations of hydrocarbons and highly toxic heavy metals in the liver subcutaneous fat Caspian seal. increased toxicant level fat, as compared to liver, pointed disorder organism purification processes, leading chronic polytoxicosis disorders histological structure internals. studies morphofunctional state stomach pinnipeds following disorders: hemorrhages, edemata necrosis mucous membrane, replacement glandular tissue with...
В нашей лаборатории в опытах с гладкими мышцами матки крысы, трахеи коровы и коронарной артерии свиньи крови человека обнаружены эндогенные модуляторы бета-адренорецепторов (бета-АР), том числе эндогенный сенсибилизатор бета-АР (ЭСБАР), повышающий эффективность активации 10-100 раз. Особенно влияние ЭСБАР проявляется условиях, при которых снижена, например, под влиянием озона или лизофосфатидилхолина (ЛФХ). Нами также установлено, что подобную ЭСБАР-активность проявляет L-гистидин,...
Abstract The dynamics of the level biological risk marker for heart failure and cardiophibrosis ST2 under influence factors space flight landing was analyzed. Plasma samples obtained from venous blood 14 cosmonauts who had flown on Russian segment ISS were studied. collected before flight, first seventh day after analyzed by means commercial test-kit "Critical Diagnostics Presage® Assay" (USA) enzyme immunoassay (ELISA). Analysis variance analysis protein levels in all revealed a significant...
DATA REPORT article Front. Physiol., 01 December 2023Sec. Environmental, Aviation and Space Physiology Volume 14 - 2023 | https://doi.org/10.3389/fphys.2023.1285802