A5027762388- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Chronic Obstructive Pulmonary Disease (COPD) Research
- SARS-CoV-2 and COVID-19 Research
- Respiratory Support and Mechanisms
- Inflammasome and immune disorders
- Obstructive Sleep Apnea Research
- SARS-CoV-2 detection and testing
- Respiratory and Cough-Related Research
- Alcohol Consumption and Health Effects
- Head and Neck Cancer Studies
- Cancer Diagnosis and Treatment
- Thermal Regulation in Medicine
- Bone Tumor Diagnosis and Treatments
- Systemic Lupus Erythematosus Research
- Kawasaki Disease and Coronary Complications
- Inhalation and Respiratory Drug Delivery
- Neuroscience of respiration and sleep
- Blood groups and transfusion
- Immune cells in cancer
- Cystic Fibrosis Research Advances
- Human Health and Disease
- Pleural and Pulmonary Diseases
- Neonatal Respiratory Health Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Hospital Universitario de La Princesa
2019-2024
Universidad Autónoma de Madrid
2021-2023
Social Welfare Department
2022
Universidad Europea
2021
Hospital Universitario Quirónsalud Madrid
2021
Hospital La Luz
2021
Clinica de Pneumologie Iaşi
2020
Hospital Universitario Puerta del Mar
1998
SARS-CoV-2 is responsible for the development of coronavirus disease 2019 (COVID-19) in infected individuals, who can either exhibit mild symptoms or progress toward a life-threatening acute respiratory distress syndrome (ARDS). Exacerbated inflammation and dysregulated immune responses involving T myeloid cells occur COVID-19 patients with severe clinical progression. However, differential contribution specific subsets dendritic monocytes to ARDS still poorly understood. In addition, role...
Abstract The SARS-CoV-2 is responsible for the pandemic COVID-19 in infected individuals, who can either exhibit mild symptoms or progress towards a life-threatening acute respiratory distress syndrome (ARDS). It known that exacerbated inflammation and dysregulated immune responses involving T myeloid cells occur patients with severe clinical progression. However, differential contribution of specific subsets dendritic monocytes to ARDS still poorly understood. In addition, role CD8 +...
Abstract Increased recruitment of transitional and non-classical monocytes in the lung during SARS-CoV-2 infection is associated with COVID-19 severity. However, whether specific innate sensors mediate activation or differentiation response to different proteins remain poorly characterized. Here, we show that Spike 1 but not nucleoprotein induce into subsets from both peripheral blood bronchoalveolar lavage samples a NFκB-dependent manner, this process does require inflammasome activation....
COVID-19 has overloaded national health services worldwide. Thus, early identification of patients at risk poor outcomes is critical. Our objective was to analyse SARS-CoV-2 RNA detection in serum as a severity biomarker COVID-19. Retrospective observational study including 193 admitted for Detection (viremia) performed with samples collected 48-72 h admission by two techniques from Roche and Thermo Fischer Scientific (TFS). Main outcome variables were mortality need ICU during...
Early kinetics of SARS-CoV-2 viral load (VL) in plasma determined by quantitative reverse-transcription polymerase chain reaction (RT-PCR) was evaluated as a predictor poor clinical outcome prospective study and assessed retrospective validation cohort. Prospective observational single-center including consecutive adult patients hospitalized with COVID-19 between November 2020 January 2021. Serial samples were obtained until discharge. Quantitative RT-PCR performed to assess VL. The main...
Abstract Background: In-hospital mortality in patients with coronavirus disease 2019 (COVID-19) is high. Simple prognostic indices are needed to identify at high-risk of COVID-19 health outcomes. We aimed determine the usefulness CONtrolling NUTritional status (CONUT) index as a potential indicator upon hospital admission. Methods: Our study design retrospective observational large cohort patients. In addition descriptive statistics, Kaplan–Meier analysis and Cox regression were performed,...
Abstract Some patients with COVID-19 pneumonia develop an associated cytokine storm syndrome that aggravates the pulmonary disease. These may benefit of anti-inflammatory treatment. The role colchicine in hospitalized and established hyperinflammation remains unexplored. In a prospective, randomized controlled, observer-blinded endpoint, investigator-initiated trial, 240 were randomly allocated to receive oral or not. primary efficacy outcome measure was composite non-invasive mechanical...
Background An association of ABO blood group and COVID-19 remains controversial. Methods Following STROBE guidance for observational research, we explored the distribution in patients hospitalized acute those with Long COVID. Contingency tables were made risk factors using crude adjusted Mantle-Haentzel odds ratios (OR 95% CI). Results Up to September 2022, there a total 5,832 hospitalizations our hospital, corresponding 5,503 individual patients, whom determination was available 1,513...
Background: Interleukin 6 (IL6) levels and SARS-CoV-2 viremia have been correlated with COVID-19 severity. The association over time between them has not assessed in a prospective cohort. Our aim was to evaluate the relationship evolution of IL6 Methods: Secondary analysis from cohort including hospitalized patients Hospital Universitario La Princesa November 2020 January 2021. Serial plasma samples were collected admission until discharge. Viral load quantified by Real-Time Polymerase Chain...
Paediatric inflammatory multisystem syndrome temporally associated with COVID-19 (PIMS-TS) or in children (MIS-C) is a new acute-onset systemic disease, which mainly affects children. Latent tuberculosis infection (LTBI) characterized by the presence of immune sensitization to Mycobacterium (MTB) absence any clinical radiological evidence active disease. We present child MIS-C related COVID-19, latent TB bone marrow, and satisfactory response tocilizumab. It important pay attention...
ABSTRACT Background COVID-19 has overloaded national health services worldwide. Thus, early identification of patients at risk poor outcomes is critical. Our objective was to analyse SARS-CoV-2 RNA detection in serum as a severity biomarker COVID-19. Methods and Findings Retrospective observational study including 193 admitted for Detection (CoVemia) performed with samples collected 48-72 hours admission by two techniques from Roche Thermo Fischer Scientific (TFS). Main outcome variables...
<b>Introduction:</b> Patients with severe asthma usually have recurrent infections, sometimes related to the presence of bronchiectasis (BE). Inhaled antibiotic therapy is widely used in BE, however we found few publications on its effect patients. The aim our study was describe characteristics patients severe, difficult-to-control who received treatment inhaled <b>Methods:</b> Retrospective observational including from Severe Asthma consultation between 2010 and 2019, under therapy. A...
Abstract Background Interleukin 6 (IL6) levels and SARS-CoV-2 viremia have been correlated with COVID-19 severity. The association over time between them has not assessed in a prospective cohort. Our aim was to evaluate the relationship evolution of IL6 Methods Secondary analysis from cohort including hospitalized patients Hospital Universitario La Princesa November 2020 January 2021. Serial plasma samples were collected admission until discharge. Viral load quantified by Real-Time...
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<b>Aim:</b> To describe associated factors to 30-day mortality of patients treated with Non-invasive respiratory therapies (NIRT) due COVID-19 failure in the Madrid Area. <b>Methods:</b> Observational study treated by Pneumologists NIRT during first five waves six third level hospitals from March 2020 August 2021, outside ICU. were classified as (1) high flow nasal cannula (HFNC), (2) continuous positive airway pressure (CPAP), (3) bi-level (BIPAP), and (4) combined therapy (HFNC +...
<b>Introduction:</b> COPD underdiagnosis remains a global concern, reaching 74.7% in Spain according to EPISCAN II. The COVID-19 pandemic collapsed many pneumology services from 2020 and onwards. We aimed characterize within our post-COVID follow-up explore its underdiagnosis. <b>Methods</b>: evaluated patients seen between April December 2022, performed descriptive analysis of their clinical functional variables. compared those with or without previous diagnosis history, most recent...