A5012384830- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- SARS-CoV-2 detection and testing
- Respiratory viral infections research
- Vasculitis and related conditions
- Cardiovascular Function and Risk Factors
- Chronic Disease Management Strategies
- Obesity, Physical Activity, Diet
- Down syndrome and intellectual disability research
- Pneumocystis jirovecii pneumonia detection and treatment
- Pneumonia and Respiratory Infections
- Galectins and Cancer Biology
- COVID-19 and healthcare impacts
- Obesity and Health Practices
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Phagocytosis and Immune Regulation
- Simulation-Based Education in Healthcare
- Immune Cell Function and Interaction
- COVID-19 and Mental Health
- Nonmelanoma Skin Cancer Studies
- Blood Pressure and Hypertension Studies
- Clinical Reasoning and Diagnostic Skills
- Abdominal vascular conditions and treatments
- Advanced Banach Space Theory
Hospital Universitario de La Princesa
2017-2025
Université Savoie Mont Blanc
2020
The University of Queensland
2019
Nantes Université
2014
Centre Hospitalier Universitaire de Nantes
2014
Observatoire Régional de la Santé et du Social
2009
Laboratoire de Probabilités et Modèles Aléatoires
2005
Le Mans Université
1997
Early kinetics of SARS-CoV-2 viral load (VL) in plasma determined by quantitative reverse-transcription polymerase chain reaction (RT-PCR) was evaluated as a predictor poor clinical outcome prospective study and assessed retrospective validation cohort. Prospective observational single-center including consecutive adult patients hospitalized with COVID-19 between November 2020 January 2021. Serial samples were obtained until discharge. Quantitative RT-PCR performed to assess VL. The main...
Monocyte-derived macrophages, the major source of pathogenic macrophages in COVID-19, are oppositely instructed by macrophage CSF (M-CSF) or granulocyte (GM-CSF), which promote generation antiinflammatory/immunosuppressive MAFB+ (M-MØ) proinflammatory (GM-MØ), respectively. The transcriptional profile prevailing subsets severe COVID-19 led us to hypothesize that MAFB shapes transcriptome pulmonary driving pathogenesis. We have now assessed role response monocyte-derived SARS-CoV-2 through...
(1) Background: The inflammation or cytokine storm that accompanies COVID-19 marks the prognosis. This study aimed to identify three risk categories based on inflammatory parameters admission. (2) Methods: Retrospective cohort of patients diagnosed with COVID-19, collected and followed-up from 1 March 31 July 2020, nationwide Spanish SEMI-COVID-19 Registry. low, intermediate, high were determined by taking into consideration terciles total lymphocyte count values C-reactive protein, lactate...
Background: This study aimed to validate the role of D-dimer lymphocyte ratio (DLR) for mortality prediction in a large national cohort hospitalized coronavirus disease 2019 (COVID-19) patients. Methods: A retrospective, multicenter, observational that included patients due SARS-CoV-2 infection Spain was conducted from March 2020 2022. All biomarkers and laboratory indices analyzed were measured once at admission. Results: total 10,575 COVID-19 this study. The mean age participants 66.9...
Valproic acid (VPA) has shown beneficial effects in vitro against SARS-CoV-2 infection, but no study analyzed its efficacy the clinical setting.This multicenter, retrospective included 165 adult patients receiving VPA at time of admission to hospital, and 330 controls matched for sex, age date admission. A number clinical, outcome laboratory parameters were recorded evaluate differences between two groups. Four major endpoints considered: development lung infiltrates, in-hospital respiratory...
Our main aim was to describe the effect on severity of ACEI (angiotensin-converting enzyme inhibitor) and ARB (angiotensin II receptor blocker) during COVID-19 hospitalization. A retrospective, observational, multicenter study evaluating hospitalized patients with treated ACEI/ARB. The primary endpoint incidence composite outcome prognosis (IMV (invasive mechanical ventilation), NIMV (non-invasive ICU admission (intensive care unit), and/or all-cause mortality). We evaluated both outcomes in...
Galectin-1 (Gal1) plays a regulatory role in the immune system. We have recently validated that Gal1 serum (sGal1) levels are increased rheumatoid arthritis (RA) patients compared to healthy donors (HDs); however, there is no information on spondyloarthritis (SpA). Objective: To compare with SpA versus RA as diagnostic biomarker. Methods: studied sGal1 HD (n = 52), 80) and 64) who were randomly divided into discovery validation sets. Synovial fluid (SF) from osteoarthritis (OA) 28),...
Abstract The tyrosine kinase inhibitor dasatinib is approved for Philadelphia chromosome–positive leukemia, including chronic myeloid leukemia (CML). Although effective and well tolerated, patients typically exhibit a transient lymphocytosis after uptake. To date, the underlying physiological process linking to remains unknown. Here, we used small rodent model examine mechanism of dasatinib-induced lymphocytosis, focusing on lymphocyte trafficking into out secondary lymphoid organs. Our data...
Galectin 1 (Gal1) exerts immunomodulatory effects leading to therapeutic in autoimmune animal models. Patients with rheumatoid arthritis have been reported show higher Gal1 serum levels than the healthy population. Our study aimed find genetic variants on gene (LGALS1) modulating its expression and/or clinical features patients early (EA). LGALS1 was sequenced 53 EA characterize all variants. Then, we genotyped rs9622682, rs929039, and rs4820293, which covered main variation LGALS1, 532...
Presence of SARS-CoV-2 RNA in serum (viraemia) COVID-19 patients has been related to poor prognosis and death. The aim this study was evaluate the ability two commercial reverse real-time-PCR (rRT-PCR) kits, cobas (Cobas test) TaqPath CE-IVD RT-PCR Kit (Taqpath test), detect viraemia their implementation as routine diagnosis microbiology laboratory. This retrospective cohort conducted with 203 adult admitted Hospital Universitario de La Princesa, (89 Intensive Care Unit 114 ward) at least...