A5042683151- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Sepsis Diagnosis and Treatment
- Nutrition and Health in Aging
- SARS-CoV-2 and COVID-19 Research
- Health Systems, Economic Evaluations, Quality of Life
- Bone health and osteoporosis research
- Heart Failure Treatment and Management
- COVID-19 and Mental Health
- Gallbladder and Bile Duct Disorders
- Adrenal Hormones and Disorders
- Respiratory Support and Mechanisms
- Gastrointestinal disorders and treatments
- Bone Metabolism and Diseases
- Frailty in Older Adults
- SARS-CoV-2 detection and testing
- Adipose Tissue and Metabolism
- Chronic Disease Management Strategies
- Erythropoietin and Anemia Treatment
- Iron Metabolism and Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Primary Care and Health Outcomes
- Diet and metabolism studies
- Adipokines, Inflammation, and Metabolic Diseases
- Birth, Development, and Health
Hospital Universitario Río Hortega
2018-2025
Littleton Adventist Hospital
2024
Universidad de Valladolid
2020-2022
Seattle Children's Hospital
2017-2022
University of Washington
2017
To determine whether a 6-day course of methylprednisolone (MP) improves outcome in patients with severe SARS-CoV‑2 (Corona Virus Disease 2019 [COVID-19]).
ABSTRACT Background We aimed to determine whether a 6-day course of intravenous methylprednisolone (MP) improves outcome in patients with SARS CoV-2 infection at risk developing Acute Respiratory Distress Syndrome (ARDS). Methods Multicentric, partially randomized, preference, open-label trial, including adults COVID-19 pneumonia, impaired gas exchange and biochemical evidence hyper-inflammation. Patients were assigned standard care (SOC), or SOC plus MP [40mg/12h 3 days, then 20mg/12h...
Oxidative stress may act as a contributing factor in the development of an elevated body mass index (BMI). has potential to modulate genetic activity at various levels, including gene transcription and protein function regulation. Nevertheless, interplay between variants oxidative relation BMI remains be elucidated. Based on this premise, we studied association 723 single-nucleotide polymorphisms (SNPs) located within set 212 genes both parameters 1502 adults from general Spanish population...
Since the first cases of COVID-19 were reported in Wuhan, nutritional status individuals infected with virus has not been included risk profiles prepared. However, status, along other factors, is decisive evolution patients infectious diseases. The considered an indicator health status. Furthermore, optimal transcends individual, and poor diet a population can be group factor. Evidence exists on influence that immune system susceptibility to disease.To evaluate older than 65 years who...
The efficacy and safety of high versus medium doses glucocorticoids for the treatment patients with COVID-19 has shown mixed outcomes in controlled trials observational studies. We aimed to evaluate effectiveness methylprednisolone 250 mg bolus dexamethasone 6 severe COVID-19.A randomised, open-label, trial was conducted between February August 2021 at four hospitals Spain. suspended after first interim analysis since investigators considered that continuing would be futile. Patients were...
(1) Background: The inflammation or cytokine storm that accompanies COVID-19 marks the prognosis. This study aimed to identify three risk categories based on inflammatory parameters admission. (2) Methods: Retrospective cohort of patients diagnosed with COVID-19, collected and followed-up from 1 March 31 July 2020, nationwide Spanish SEMI-COVID-19 Registry. low, intermediate, high were determined by taking into consideration terciles total lymphocyte count values C-reactive protein, lactate...
Background: Osteoporosis and obesity are major public health problems that closely correlated, as they share various features, including a genetic predisposition. A correlation between osteoporosis due to the biological common pathways of bone fat metabolism, which implies pleiotropic genes regulating has been described. The objective our study was analyse whether polymorphisms in obesity-related modify risk osteoporotic fracture. Methods: We studied 575 subjects from Hortega Study. were...
Abstract Objectives Spanish population lifespan is one of the longest in world. Moreover, it known that elderly people have less chronic illnesses associated with aging. Our aims were to determine how Clinical Risk Group (CRG) predicts future use healthcare resources extremely without diabetes (T2DM) and explore CRG correlation health conditions. Design Prospective cross-sectional study. Setting Rio Hortega University Hospital. Participants Hospitalized patients >80 years old T2DM,...
The SARS-CoV-2 coronavirus is responsible for the COVID-19 pandemic resulting in a global health emergency. Given its rapid spread and high number of infected individuals, diagnostic tool rapid, simple, cost-effective detection was essential. In this work, we developed test, that incorporates human internal control, based on Reverse Transcription Loop-Mediated Isothermal Amplification (RT-LAMP). When working with synthetic RNA, optimized RT-LAMP assay has sensitivity 10 viral copies can be...
To assess the relationship between FRAX index and Barthel index/MiniMental State Examination in older people.Observational descriptive study. Demographic data, comorbidity, dependency cognitive state, risk of osteoporotic fracture were collected.A total 375 patients included (60% female) Patients with a low-risk for hip fractures had higher Mini-mental (25, 95% CI = 24-27 vs. 22, 21 to 23, p .0001), (88, 84-93 vs 72, 69 76, .0001) without differences Charlson index. Bivariate analysis showed...
Summary Background The incidence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV‑2) infection was highest among older adults early in the COVID-19 pandemic; however, this pattern later reversed with young showing incidence. aim study to identify risk factors healthcare workers (HCWs) associated evolution. Methods We conducted a survey nested within prospective cohort 680 HCWs from tertiary referral public hospital who received doses SARS-CoV‑2 vaccine January and February 2021...
Clostridioides difficile infection (CDI) is the leading cause of healthcare-associated diarrhea. The associated with a high mortality rate and risk recurrence. We assessed factors for death or recurrent CDI in patients diabetes mellitus (DM).