A5045644049- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Respiratory viral infections research
- Long-Term Effects of COVID-19
- Sepsis Diagnosis and Treatment
- Pneumonia and Respiratory Infections
- Influenza Virus Research Studies
- Viral gastroenteritis research and epidemiology
- SARS-CoV-2 detection and testing
- COVID-19 Impact on Reproduction
- Aquaculture disease management and microbiota
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pediatric health and respiratory diseases
- Bacterial Identification and Susceptibility Testing
- Adrenal Hormones and Disorders
- Neonatal Respiratory Health Research
- Biosensors and Analytical Detection
- Diabetes and associated disorders
- Vibrio bacteria research studies
- Neonatal and Maternal Infections
- Inflammation biomarkers and pathways
- Asthma and respiratory diseases
- Bacteriophages and microbial interactions
- Microbial infections and disease research
Instituto de Investigación Biomédica de Salamanca
2021-2024
Instituto de Salud Carlos III
2020-2024
Centro de Investigación Biomédica en Red
2023-2024
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
2020-2024
Andalusian School of Public Health
2023
Hospital Universitario Río Hortega
2021-2022
Abstract Background COVID-19 can course with respiratory and extrapulmonary disease. SARS-CoV-2 RNA is detected in samples but also blood, stool urine. Severe characterized by a dysregulated host response to this virus. We studied whether viral RNAemia or load plasma associated severe response. Methods A total of 250 patients were recruited (50 outpatients, 100 hospitalized ward critically ill). Viral detection quantification was performed using droplet digital PCR, targeting the N1 N2...
Abstract Background Anti‐SARS‐CoV‐2 S antibodies prevent viral replication. Critically ill COVID‐19 patients show material in plasma, associated with a dysregulated host response. If these influence survival and dissemination ICU‐COVID is unknown. Patients/Methods We studied the impact of anti‐SARS‐CoV‐2 levels on survival, RNA‐load N‐antigenaemia 92 over ICU admission. Results Frequency was >2.5‐fold higher absence antibodies. Antibodies correlated inversely representing protective...
Identifying patients with COVID-19 who are at risk of poor evolution is key to early decide on their hospitalization. We evaluated the combined impact nucleocapsid (N)-antigenemia profiled by a rapid test and antibodies against S1 subunit SARS-CoV S protein (S1) hospitalization COVID-19.
Abstract Purpose to evaluate the association between anti-SARS-CoV-2 S IgM and IgG antibodies with viral RNA load in plasma, frequency of antigenemia risk mortality critically ill patients COVID-19. Methods levels, were profiled plasma 92 adult first 24 hours following ICU admission. The impact these variables on 30-day was assessed by using Kaplan-Meier curves multivariate Cox regression analysis. Results non survivors showed more frequently absence than (26.3% vs 5.6% for 18.4% IgG), a...
Abstract Background Fever‐7 is a test evaluating host mRNA expression levels of IFI27, JUP, LAX, HK3, TNIP1, GPAA1 and CTSB in blood able to detect viral infections. This has been validated mostly hospital settings. Here we have evaluated identify the presence respiratory infections Community Health Center. Methods A prospective study was conducted “Servicio de Urgencias Atención Primaria” Salamanca, Spain. Patients with clinical signs infection at least one point National Early Warning...
Background: Severe COVID-19 has been proposed to represent a form of viral sepsis. The prevalence sepsis due this disease not evaluated. Some patients with severe present SARS-CoV-2 antigenemia. Whether antigenemia constitutes factor associated and fatal outcome in these is unknown. Methods: This study recruited 400 hospitalized COVID-19. Prevalence the first 24 hours following hospitalization was determined using SEPSIS-3 criteria. concentration N-antigenemia plasma at Panbio® Ag Rapid Test...
Abstract Objective the biomarkers’ performance for diagnosis and severity stratification of sepsis has not been properly evaluated anew using SEPSIS-3 criteria introduced in 2016. We accuracy 21 biomarkers classically tested research to identify infection, sepsis, septic shock surgical patients classified SEPSIS-3. Methods four groups adult were compared: post-surgical with no infection but recruited prospectively from surgery departments ICUs Spanish hospital. The area under curve (AUC)...
Abstract Early detection of patients with respiratory infection at risk deteriorating could help to improve their outcome by facilitating immediate transfer the hospital receive adequate level care. In this regard, gene expression profiling is emerging as a promising tool identify suffering complicated outcome. cohort attending an Emergency Room community health centre, we quantified levels in blood five genes involved granulocyte biology that have been previously described be linked...