Clara Gort‐Paniello
A5000834580- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Intensive Care Unit Cognitive Disorders
- Respiratory Support and Mechanisms
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Thermal Regulation in Medicine
- COVID-19 and Mental Health
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neurological disorders and treatments
- Circadian rhythm and melatonin
- Sepsis Diagnosis and Treatment
- Genetic Neurodegenerative Diseases
- Neuroscience and Neuropharmacology Research
- Respiratory viral infections research
- Inflammation biomarkers and pathways
- Adrenal Hormones and Disorders
- SARS-CoV-2 detection and testing
- Sleep and related disorders
- Hematological disorders and diagnostics
- Optimism, Hope, and Well-being
- Family and Patient Care in Intensive Care Units
- COVID-19 diagnosis using AI
- RNA Interference and Gene Delivery
- Cardiovascular Health and Disease Prevention
Biomedical Research Institute of Lleida
2021-2024
Hospital Universitari Arnau de Vilanova
2021-2024
Instituto de Salud Carlos III
2021-2024
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
2021-2024
Centro de Investigación Biomédica en Red
2022-2024
Centro de Investigación en Red en Enfermedades Cardiovasculares
2022
Departament de Salut
2020
Universitat de Barcelona
2020
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2020
Biomedical Research Networking Center on Neurodegenerative Diseases
2020
We evaluated whether the time between first respiratory support and intubation of patients receiving invasive mechanical ventilation (IMV) due to COVID-19 was associated with mortality or pulmonary sequelae.
OBJECTIVES: To investigate the sleep and circadian health of critical survivors 12 months after hospital discharge to evaluate a possible effect severity disease within this context. DESIGN: Observational, prospective study. SETTING: Single-center PATIENTS: Two hundred sixty patients admitted ICU due severe acute respiratory syndrome coronavirus 2 infection. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: The cohort was composed 260 (69.2% males), with median (quartile 1–quartile 3) age...
To evaluate the sleep and circadian rest-activity pattern of critical COVID-19 survivors 3 months after hospital discharge.Observational, prospective study.Single-center study.One hundred seventy-two consecutive admitted to ICU with acute respiratory distress syndrome.Seven days actigraphy for assessment; validated questionnaires; tests at 3-month follow-up.The cohort included 172 patients, mostly males (67.4%) a median (25th-75th percentile) age 61.0 years (52.8-67.0 yr). The number was...
The long-term clinical management and evolution of a cohort critical COVID-19 survivors have not been described in detail. We report prospective observational study patients admitted to the ICU between March August 2020. follow-up post-COVID consultation comprised symptoms, pulmonary function tests, 6-minute walking test (6MWT), chest computed tomography (CT). Additionally, questionnaires evaluate prevalence post-COVID-19 syndrome were administered at 1 year. A total 181 during period. They...
Circulating cell-free microRNAs (miRNAs) are promising biomarkers for medical decision-making. Suitable endogenous controls essential to ensure reproducibility. We aimed identify and validate reference miRNAs qPCR data normalization in samples from SARS-CoV-2-infected hospitalized patients. used plasma (n = 170) COVID-19 patients collected at hospital admission (COVID-Ponent project, www.clinicaltrials.gov/NCT04824677). First, 179 were profiled using RT–qPCR. After stability assessment,...
Huntington’s disease (HD) is a neurological disorder characterized by motor disturbances. HD pathology most prominent in the striatum, central hub of basal ganglia. The cerebral cortex main striatal afferent, and progressive cortico-striatal disconnection characterizes HD. We mapped network dysfunction mice to ultimately modulate activity specific circuit ameliorate symptoms recover synaptic plasticity. Multimodal MRI vivo indicates thalamo-striatal functional deficits reduced...
The pathophysiology of COVID-19-related critical illness is not completely understood. Here, we analyzed the microRNA (miRNA) profile bronchial aspirate (BAS) samples from COVID-19 and non-COVID-19 patients admitted to ICU identify prognostic biomarkers fatal outcomes define molecular pathways involved in disease adverse events.Two patient populations were included (n = 89): (i) a study population composed critically ill patients; (ii) prospective cohort survivors non-survivors among...
There is a limited understanding of the pathophysiology postacute pulmonary sequelae in severe COVID-19. The aim current study was to define circulating microRNA (miRNA) profiles associated with function and radiologic features survivors SARS-CoV-2-induced ARDS. included patients who developed ARDS secondary SARS-CoV-2 infection (n = 167) group infected did not develop 33). Patients were evaluated 3 months after hospital discharge. follow-up complete evaluation chest computed tomography....
Abstract Background and Purpose The post‐acute sequelae of SARS‐CoV‐2 infection pose a significant global challenge, with nearly 50% critical COVID‐19 survivors manifesting persistent lung abnormalities. lack understanding about the molecular mechanisms effective treatments hampers their management. Here, we employed microRNA (miRNA) profiling to decipher systemic underpinnings pulmonary complications. Experimental Approach We conducted longitudinal investigation including 119 survivors. A...
The identification of critically ill COVID-19 patients at risk fatal outcomes remains a challenge. Here, we first validated candidate microRNAs (miRNAs) as biomarkers for clinical decision-making in patients. Second, constructed blood miRNA classifier the early prediction adverse ICU.This was multicenter, observational and retrospective/prospective study including 503 admitted to ICU from 19 hospitals. qPCR assays were performed plasma samples collected within 48 h upon admission. A 16-miRNA...
The clinical heterogeneity of COVID-19 suggests the existence different phenotypes with prognostic implications. We aimed to analyze comorbidity patterns in critically ill patients and assess their impact on in-hospital outcomes, response treatment sequelae.Multicenter prospective/retrospective observational study intensive care units 55 Spanish hospitals. 5866 PCR-confirmed had comorbidities recorded at hospital admission; biological parameters, procedures complications throughout stay;...
Bronchial aspirates (BAS) obtained during invasive mechanical ventilation (IMV) constitutes a useful tool for molecular phenotyping and decision making.To identify the proteomic determinants associated with disease pathogenesis, all-cause mortality respiratory sequelae in BAS samples from critically ill patients SARS-CoV-2-induced ARDS.Multicenter study including 74 COVID-19 non-COVID-19 ARDS. were by bronchoaspiration after IMV initiation. Three hundred sixty-four proteins quantified using...
Up to 80% of patients surviving acute respiratory distress syndrome (ARDS) secondary SARS-CoV-2 infection present persistent anomalies in pulmonary function after hospital discharge. There is a limited understanding the mechanistic pathways linked post-acute sequelae. To identify molecular underpinnings associated with severe lung diffusion involvement survivors SARS-CoV-2-induced ARDS. Survivors attended complete evaluation 3 months RNA sequencing (RNA-seq) was performed using Illumina...
The objective was to describe the clinical characteristics and outcomes of hospitalized COVID-19 patients during two different epidemic periods. Prospective, observational, cohort study COVID-19. A total 421 consecutive were included, 188 first period (March-May 2020) 233 in second wave (July-December 2020). Clinical, epidemiological, prognostic therapeutic data compared. Patients outbreak older more comorbid, presented worse PaO2/FiO2 ratio an increased creatinine D-dimer levels at hospital...
<title>Abstract</title> Background COPD patients show higher mortality and worse prognosis in the acute phase of COVID-19, survivors may suffer persistent symptoms that could make them more vulnerable to exacerbations. Objectives We aimed evaluate impact COVID-19 on exacerbations, symptoms, quality life, mental health a cohort patients. Methods Retrospective case-control single-centre study including all from pulmonary consultation University Hospital Santa Maria (Lleida, Spain) surviving...