A5013607999- Sepsis Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Intensive Care Unit Cognitive Disorders
- COVID-19 Clinical Research Studies
- Acute Myocardial Infarction Research
- Thermal Regulation in Medicine
- Antibiotic Resistance in Bacteria
- Traumatic Brain Injury and Neurovascular Disturbances
- Pneumonia and Respiratory Infections
- Adrenal Hormones and Disorders
- Long-Term Effects of COVID-19
- Nosocomial Infections in ICU
- Cardiac Arrest and Resuscitation
- Antibiotics Pharmacokinetics and Efficacy
- Economic and Social Development
- Renal function and acid-base balance
- Heart Failure Treatment and Management
- Antibiotic Use and Resistance
- Climate Change and Geoengineering
- Cardiac electrophysiology and arrhythmias
- Ethics and bioethics in healthcare
- Earth Systems and Cosmic Evolution
- Clinical Nutrition and Gastroenterology
- Bacterial biofilms and quorum sensing
- Electrolyte and hormonal disorders
Hospital Universitario Son Espases
2011-2024
Health Research Institute of the Balearic Islands
2017-2024
Universidad de Valladolid
2019
University of the Basque Country
2008-2012
Hospital Universitario Son Dureta
2002-2011
University of Zulia
2011
Intensive Care Society
2009
European Society of Intensive Care Medicine
2007
Servei de Salut de les Illes Balears
2004
Research Institute of Health Sciences
2004
This study assessed the molecular epidemiology, resistance mechanisms, and susceptibility profiles of a collection 150 extensively drug-resistant (XDR) Pseudomonas aeruginosa clinical isolates obtained from 2015 Spanish multicenter study, with particular focus on resistome analysis in relation to ceftolozane-tazobactam susceptibility. Broth microdilution MICs revealed that nearly all (>95%) were nonsusceptible piperacillin-tazobactam, ceftazidime, cefepime, aztreonam, imipenem, meropenem,...
The CIGMA study investigated a novel human polyclonal antibody preparation (trimodulin) containing ~ 23% immunoglobulin (Ig) M, 21% IgA, and 56% IgG as add-on therapy for patients with severe community-acquired pneumonia (sCAP). In this double-blind, phase II (NCT01420744), 160 sCAP requiring invasive mechanical ventilation were randomized (1:1) to trimodulin (42 mg IgM/kg/day) or placebo five consecutive days. Primary endpoint was ventilator-free days (VFDs). Secondary endpoints included...
All extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae isolates from patients admitted to and adult intensive care unit were prospectively documented 2002 2005, when a large outbreak (51 affected) of multiresistant ESBL-producing Klebsiella pneumoniae infection was detected. The involvement single K. clone demonstrated by pulsed-field gel electrophoresis. In addition the ESBL-mediated resistance, epidemic strain uniformly showed cross-resistance ciprofloxacin, gentamicin,...
Abstract Introduction Hematology patients admitted to the ICU frequently experience respiratory failure and require mechanical ventilation. Noninvasive ventilation (NIMV) may decrease risk of intubation, but NIMV poses its own risks. Methods To establish impact ventilatory management on outcome, data from a prospective, multicenter, observational study were analyzed. All hematology one 34 participating ICUs in 17-month period followed up. Data demographics, diagnosis, severity, organ...
Abstract Background Mortality due to COVID-19 is high, especially in patients requiring mechanical ventilation. The purpose of the study investigate associations between mortality and variables measured during first three days ventilation with intubated at ICU admission. Methods Multicenter, observational, cohort includes consecutive admitted 44 Spanish ICUs February 25 July 31, 2020, who required intubation admission for more than days. We collected demographic clinical data prior...
Abstract Background The relative contribution of the different components mechanical power to mortality is a subject debate and has not been studied in COVID-19. aim this study evaluate both total impact each on well-characterized cohort patients with COVID-19-induced acute respiratory failure undergoing invasive ventilation. This secondary analysis CIBERESUCICOVID project, multicenter observational including fifty Spanish intensive care units that included COVID-19 mechanically ventilated...
Aim: The specific incidence of ischemic hepatitis in septic shock patients remains unknown. aim this study was to evaluate the and its relationship with mortality. Methods: We retrospectively studied 181 admitted intensive care unit (ICU). defined as having a value serum aminotransferases equal or higher than 1000 IU/L. recorded age, sex, comorbidity, site infection, Sequential Organ Failure Assessment (SOFA) score on admission ICU, maximum SOFA inadequate antibiotic therapy. Results:...
Abstract Background Community-acquired (CA) and healthcare-associated (HCA) infections caused by carbapenemase-producing Enterobacterales (CPE) are not well characterized. The objective was to provide detailed information about the clinical molecular epidemiological features of nosocomial, HCA CA Klebsiella pneumoniae (CP-Kp) Escherichia coli (CP-Ec). Methods A prospective cohort study performed in 59 Spanish hospitals from February March 2019, including first 10 consecutive patients whom...