A5011871572- Antibiotic Resistance in Bacteria
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Tuberculosis Research and Epidemiology
- Antibiotics Pharmacokinetics and Efficacy
- Mycobacterium research and diagnosis
- Urinary Tract Infections Management
- Bacterial Identification and Susceptibility Testing
- Viral gastroenteritis research and epidemiology
- Pneumonia and Respiratory Infections
- Reproductive tract infections research
- Antibiotic Use and Resistance
- Respiratory viral infections research
- Syphilis Diagnosis and Treatment
- Streptococcal Infections and Treatments
- Infective Endocarditis Diagnosis and Management
- Urinary Bladder and Prostate Research
- Clinical Nutrition and Gastroenterology
- Bacterial Infections and Vaccines
- Escherichia coli research studies
- Diagnosis and treatment of tuberculosis
- Emergency and Acute Care Studies
- Pediatric Urology and Nephrology Studies
- Enterobacteriaceae and Cronobacter Research
- Pneumocystis jirovecii pneumonia detection and treatment
Vall d'Hebron Hospital Universitari
2020-2025
Instituto de Salud Carlos III
2019-2024
Centro de Investigación Biomédica en Red
2024
Vall d'Hebron Institut de Recerca
2017-2024
Universitat Autònoma de Barcelona
1998-2023
Universitat de Barcelona
2022
Universitat Internacional de Catalunya
2022
Red Espanola de Investigacion en Patologia Infecciosa
2019-2022
Agència de Salut Pública de Catalunya
2022
Hospital Sant Joan de Déu Barcelona
2022
Experiments were performed to test whether conjugated bile acid administration would decrease bacterial overgrowth, translocation, and endotoxemia in ascitic cirrhotic rats. Cholylsarcosine, a deconjugation–dehydroxylation resistant cholylglycine, susceptible used. Rats with CCl 4 –induced cirrhosis ascites fed cholylsarcosine, cholylglycine (both at 70 mg/kg/d), or placebo for 2 weeks. Healthy rats, as controls, treated similarly. In rats receiving placebo, secretion from an acute biliary...
Deranged intestinal motility, which occurs in cirrhosis, may facilitate the development of bacterial overgrowth (IBO), can lead to translocation (BT). To assess effect cisapride on IBO and BT cirrhotic rats received or a placebo for 7 days, measurements jejunal content studies were performed. In addition, fluid from 46 patients was obtained quantitative culture. Those whom gram-negative detected randomized receive not (20 mg twice per day) 1 week. Cisapride significantly reduced rats. no...
This is a retrospective single-center study of 24 patients who received ceftazidime-avibactam plus aztreonam (CZA/ATM) for the treatment VIM-type-producing Gram-negative bacillus (GNB) infections. The bacteria isolated were Enterobacterales in 22 and Pseudomonas aeruginosa 2. Sixteen out 19 isolates showed synergistic activity. Two presented clinical failure at day 14, 30-day mortality was 17% (4/24).
Invasive meningococcal disease (IMD) is associated with significant global morbidity and mortality addressed by conjugated polysaccharide subcapsular vaccines. In Spain, data on 4CMenB vaccine strain coverage antimicrobial susceptibility are limited. This study aimed to describe the genomic epidemiology, predict coverage, assess of 323 Neisseria meningitidis isolates causing IMD, collected from 57 Clinical Microbiology Laboratories in Spain over 12 years (2011/12-2022/23). Whole genome...
Abstract Background Several countries have recently reported the detection of ESBL-producing Shigella sonnei associated with transmission among MSM. In a previous study by our group, 2.8% spp. obtained from MSM in Barcelona between 2015 and 2019 were ESBL producers. Objectives To describe characterize emerging sexual detected 2020 to 2021 Barcelona, elucidating their connectivity contemporaneous other countries. Results From 2021, we identified that MSM, 68% S. XDR harbouring blaCTX-M-27 14%...
Bacterial translocation (BT) can be involved in the pathogenesis of severe infections due to bacteria enteric origin that complicates bleeding cirrhotic patients. To assess effect hemorrhagic shock (HS) on incidence BT and if selective intestinal decontamination (SID) reduces this incidence, we studied six groups Sprague-Dawley rats: ascitic rats, rats exposed HS with without previous norfloxacin prophylaxis, healthy shocked prophylaxis. tended higher than (69% vs. 41%, P = .15) was...
The aim of the current study was to compare community-acquired acute pyelonephritis (CA-APN) with health care-associated (HCA-APN), describe outcomes, and identify variables that could predict antimicrobial susceptibility. We conducted an observational included all consecutive episodes (APN) in adults during 2014 at a Spanish university hospital. From each episode, demographic data, comorbidities, clinical presentation, microbiological therapy, outcome were recorded. A multivariable logistic...
Gonococcal infection is one of the most reported sexually transmitted infections and antimicrobial resistance in Neisseria gonorrhoeae (NG) challenging for treatment this infection. This observational study aimed to describe NG epidemiological data from patients with gonococcal eight regions Spain, updating local therapeutic guidelines.MICs penicillin, cefixime, ceftriaxone, azithromycin, ciprofloxacin, fosfomycin gentamicin were determined by Etest all isolates recovered 1 April 2018 30...
Abstract Objectives Our aim was to describe the frequency and severity of infectious complications after chimeric antigen receptor (CAR) T‐cell therapy in patients with large B‐cell lymphoma (LBCL). Methods We retrospectively reviewed clinical records LBCL treated CD19‐targeted CAR from July/2018 December/2021 at our institution, identified all episodes infusion until disease progression, death or last follow‐up. Results Overall, 137 were included. Thirty six percent had received ≥3 previous...
Abstract Background Community-acquired (CA) and healthcare-associated (HCA) infections caused by carbapenemase-producing Enterobacterales (CPE) are not well characterized. The objective was to provide detailed information about the clinical molecular epidemiological features of nosocomial, HCA CA Klebsiella pneumoniae (CP-Kp) Escherichia coli (CP-Ec). Methods A prospective cohort study performed in 59 Spanish hospitals from February March 2019, including first 10 consecutive patients whom...
VIM-type-producing Gram-negative bacteria (GNB) infections are difficult to treat. This is a retrospective single-center study of 34 patients who received cefiderocol for the treatment GNB infections, including 25
Cefiderocol is a novel siderophore-conjugated cephalosporin developed for the treatment of multidrug-resistant Gram-negative bacterial (GNB) infections. However, current gold standard cefiderocol susceptibility testing, broth microdilution (BMD) using iron-depleted cation-adjusted Mueller-Hinton broth, presents challenges many microbiology laboratories. In this study, we evaluate real-world performance disc diffusion (DD) and commercial BMD method (ComASP
Introduction Increasing rates of antimicrobial resistance in Neisseria gonorrhoeae cause problems for treating gonorrhoea. Aim This observational study aimed to describe isolates from all patients found infected with N. , Barcelona, Spain, between 2013 and 2017, available susceptibility data. Methods Minimum inhibitory concentrations (MICs) penicillin (PEN), cefixime (CFM), ceftriaxone (CRO), azithromycin (AZM), ciprofloxacin (CIP), spectinomycin (SPT), fosfomycin (FOF) gentamicin (GEN) were...
We analyzed the effect of COVID-19 on healthcare demand and invasive pneumococcal disease in children Catalonia, Spain. Compared with 2018-2019, we noted large reductions activities incidence 2020. These changes likely resulted from nonpharmaceutical measures implemented during pandemic.
Introduction Infections caused by carbapenem-resistant Enterobacterales (CRE) and Pseudomonas aeruginosa , including isolates producing acquired carbapenemases, constitute a prevalent health problem worldwide. The primary objective of this study was to determine the distribution different carbapenemases among carbapenemase-producing (CPE, specifically Escherichia coli Klebsiella pneumoniae Enterobacter cloacae complex, aerogenes ) P. (CPPA) in Spain from January 2014 December 2018. Methods A...
The Gen-Probe Amplified Mycobacterium Tuberculosis Direct Test (AMTDT) was adapted for the detection of tuberculosis complex in 224 nonrespiratory specimens from 188 patients. sensitivity and specificity AMTDT such specimens, after resolution discrepant results, were 85.7 100%, respectively. Pretreatment with sodium dodecyl (lauryl) sulfate is mandatory to obtain consistent reproducible results. use 500 microliters decontaminated specimen improves test. Because detects stable rRNA...
We evaluated a rapid point-of-care test for the detection of Chlamydia trachomatis in specimens from 278 sex workers attending sexually transmitted infection clinics Guatemala. The sensitivity and specificity compared to results PCR were 62.96% 99.60%, respectively. performed moderately well as screening tool context which clinical follow-up visits are infrequent.
The progressive increase of infections produced by extensively drug-resistant carbapenemase-producing Klebsiella pneumoniae (XDR-CPKP) represents an important threat to public health. Unfortunately, optimal therapeutic options are scarce. Retrospective studies have recommended combined therapy with more than one antibiotic and, recently, a double-carbapenem regimen has been reported be effective alternative therapy. Here, we describe episode sepsis in immunocompromised patient after...
It is well known that one of the differences between murine and human tuberculosis lack intragranulomatous necrosis in former. The aim this study was to create a feasible reproducible model an experimental which should be present. Considering Shwartzman reaction as possible explanation for tuberculosis, C57Bl/6 mice, infected aerogenically with virulent strain Mycobacterium were intranasally inoculated lipopolysaccharide (LPS) on day 19 postinfection (p.i.). Twenty-four hours later,...
We found that with the incorporation of PCV13 vaccine, numbers IPD cases caused by serotypes included in this vaccine decreased all age groups. Still, there was an unforeseen increase not causing IPD, especially >65-year-old group.
Background: There is no experience with ciprofloxacin for the treatment of carbapenemase-producing Gram-negative bacteria (CP-GNB) infections. Methods: This a retrospective single-centre study where we describe clinical evolution all consecutive adult patients who received monotherapy CP-GNB Primary outcomes were failure (defined as death, lack improvement or switch to another drug) at day 14 and 30-day all-cause mortality. Results: Nineteen included. Fifteen (79%) men, median age was 74...