A5015284610- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Reproductive tract infections research
- Respiratory viral infections research
- Syphilis Diagnosis and Treatment
- SARS-CoV-2 detection and testing
- Long-Term Effects of COVID-19
- Cytomegalovirus and herpesvirus research
- Viral gastroenteritis research and epidemiology
- Microbial infections and disease research
- Viral Infections and Immunology Research
- Sex work and related issues
- COVID-19 epidemiological studies
- Herpesvirus Infections and Treatments
- Blood groups and transfusion
- Animal Virus Infections Studies
- Genital Health and Disease
- Vaccine Coverage and Hesitancy
- COVID-19 and Mental Health
- CAR-T cell therapy research
- Multiple Sclerosis Research Studies
- Bacterial Infections and Vaccines
- Pneumonia and Respiratory Infections
- COVID-19 and healthcare impacts
- vaccines and immunoinformatics approaches
Vall d'Hebron Hospital Universitari
2015-2025
Universitat Autònoma de Barcelona
2015-2025
Centro de Investigación en Red en Enfermedades Cardiovasculares
2025
Vall d'Hebron Institut de Recerca
2016-2024
Instituto de Salud Carlos III
2022-2024
Centro de Investigación Biomédica en Red
2022-2024
Hebron University
2021-2022
Hospital Universitario 12 De Octubre
2022
Instituto de Investigación de Enfermedades Raras
2022
Hospital Universitari Germans Trias i Pujol
2022
Abstract Resident memory T cells (T RM ) positioned within the respiratory tract are probably required to limit SARS-CoV-2 spread and COVID-19. Importantly, mostly non-recirculating, which reduces window of opportunity examine these in blood as they move lung parenchyma. Here, we identify circulating virus-specific cell responses during acute infection with functional, migratory apoptotic patterns modulated by viral proteins associated clinical outcome. Disease severity is predominantly IFNγ...
Hepatitis B vaccination (HBV) requires 6 months to complete and is recommended for patients with multiple sclerosis (PWMS), particularly those who are candidates anti-CD20 therapy. However, limited data exist on HBV immunogenicity in PWMS receiving disease-modifying therapies (DMTs) the impact of starting therapy during immunization. We aimed evaluate vaccination, focusing number doses received before initiation. conducted a retrospective analysis prospective cohort adult at single center...
Abstract Background The role of children in household transmission severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains unclear. We describe the epidemiological and clinical characteristics with disease 2019 (COVID-19) Catalonia, Spain, investigate dynamics. Methods A prospective, observational, multicenter study was performed during summer school periods (1 July 2020–31 October 2020) to analyze features viral dynamics COVID-19 patients aged <16 years. pediatric index...
OBJECTIVESThis study investigated the prevalence, genetic diversity, and evolution of human respiratory syncytial virus (HRSV) in Barcelona from 2013 to 2023.METHODSRespiratory specimens patients with RTI suspicion at Hospital Universitari Vall d'Hebron were collected October/2013 May/2023 for laboratory-confirmation viruses. Next-generation sequencing was performed randomly-selected samples Illumina technology. Phylogenetic analyses whole genome sequences BEAST v1.10.4. Signals selection...
The SARS-CoV-2 spike (S) protein, the viral mediator for binding and entry into host cell, has sparked great interest as a target vaccine development treatments with neutralizing antibodies. Initial data suggest that virus low mutation rates, but its large genome could facilitate recombination, insertions, deletions, been described in other coronaviruses. Here, we deep-sequenced complete S gene from 18 patients (10 mild 8 severe COVID-19), found accumulates deletions upstream very close to...
Abstract During the coronavirus disease pandemic in Spain, from April 10–24, 2020, a total of 5,869 persons were screened for severe acute respiratory syndrome 2 at nursing homes. Among residents, 768 (23.9%) tested positive; among staff, 403 (15.2%). Of those testing positive, 69.7% residents and 55.8% staff asymptomatic.
Serological tests are essential for the control and management of COVID-19 pandemic (diagnostics surveillance, epidemiological immunity studies). We introduce a direct serological biosensor assay employing proprietary technology based on plasmonics, which offers rapid (<15 min) identification quantification severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies in clinical samples, without signal amplification. The portable plasmonic device employs custom-designed...
ABSTRACT Candidemia studies have documented geographic differences in rates and epidemiology, underscoring the need for surveillance to monitor trends. We conducted prospective candidemia Spain assess incidence, species distribution, frequency of antifungal resistance, risk factors acquiring a Candida infection. Prospective laboratory-based was from June 2008 2009 40 medical centers located around country. A case defined as isolation blood culture. Incidence were calculated per 1,000...
Neither breakpoints (BPs) nor epidemiological cutoff values (ECVs) have been established for Candida spp. with anidulafungin, caspofungin, and micafungin when using the Sensititre YeastOne (SYO) broth dilution colorimetric method. In addition, reference caspofungin MICs so far proven to be unreliable. species wild-type (WT) MIC distributions (for microorganisms in a species/drug combination no detectable phenotypic resistance) were 6,007 albicans, 186 C. dubliniensis, 3,188 glabrata complex,...
Abstract Mycoplasma pneumoniae is a bacterial human pathogen that causes primary atypical pneumonia. M. motility and infectivity are mediated by the immunodominant proteins P1 P40/P90, which form transmembrane adhesion complex. Here we report structure of P1, determined X-ray crystallography cryo-electron microscopy, P40/P90. Contrary to what had been suggested, binding site for sialic acid was found in P40/P90 not P1. Genetic clinical variability concentrates on N-terminal domain surfaces...
Data are scarce on cytomegalovirus (CMV) replication in patients receiving CD19-directed chimeric antigen receptor (CAR) T cell treatment. Here we describe the incidence, severity, and management of CMV infection with aggressive B lymphoma treated CAR therapy. In this retrospective observational study, analyzed viral load its clinical impact therapy between July 2018 December 2021 at a single center. Patients negative baseline IgG or previous allogeneic stem transplantation were excluded....
Background. Recently, different therapeutic lines have been tried in the initial stage of disease COVID-19, including remdesivir and molnupiravir. There is scarce evidence on efficacy safety molnupiravir kidney transplant recipients (KTRs). Methods. ingle-center prospective cohort study‚ all adult KTRs diagnosed with COVID-19 treated or from January to April 2022 were included. Results. Nine SARS-CoV-2 (Omicron variant) infection mild symptoms received an outpatient basis compared a similar...
Abstract Resident memory T cells (T RM ) present at the respiratory tract may be essential to enhance early SARS-CoV-2 viral clearance, thus limiting infection and disease. While long-term antigen-specific are detectable beyond 11 months in lung of convalescent COVID-19 patients, it is unknown if mRNA vaccination encoding for S-protein can induce this frontline protection. Here we show that frequency CD4 + secreting IFNγ response S-peptides variable but overall similar mRNA-vaccinated...
Vaccination in patients with highly active multiple sclerosis (MS) requiring prompt treatment initiation may result impaired vaccine responses and/or delay.
Since 2000, substantial increases in syphilis men who have sex with (MSM) been reported many cities. Condomless anal (CAS) is one of the factors, along drugs for and group. This study identified factors clinical manifestations as well Treponema pallidum (T.pallidum) strains that could be related to early Barcelona.This prospective was conducted a sexually transmitted infections unit 2015. Epidemiological, behavioral, microbiological variables were collected structured form. Univariate...
The effect of disease-modifying therapies on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine response is unclear.We aim to determine the immunological responses SARS-CoV-2 in multiple sclerosis (MS) and anti-CD20-treated patients with other autoimmune diseases (AID).Humoral cellular we determined before 30-90 days after vaccination MS AID two Catalan centers.457 were enrolled. Findings showed that humoral decreased under anti-CD20s or sphingosine 1-phosphate receptor...
Information about humoral and cellular responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody persistence in convalescent (COVID-19) patients with multiple sclerosis (PwMS) is scarce. The objectives of this study were investigate factors influencing SARS-CoV-2 its COVID-19 PwMS.This a retrospective confirmed PwMS identified between February 2020 May 2021 by testing. We examined relationships demographics, MS characteristics, disease-modifying therapy (DMT),...
BackgroundSexually transmitted infections (STIs) rates have increased in the last two decades Western world, including syphilis. Higher of syphilis lead to emergence atypical or less common manifestations like Follmann's balanitis. balanitis is an presentation primary characterized as erythematous, erosive lesions on glans penis.MethodsThe aim study describe cases Follmann 's diagnosed Vall d'Hebron-Drassanes STI Unit over 20 years (2003-2023). Retrospectively, epidemiological, clinical and...