A5074476329- Bacterial Identification and Susceptibility Testing
- Antibiotic Resistance in Bacteria
- Antimicrobial Resistance in Staphylococcus
- Streptococcal Infections and Treatments
- Antibiotics Pharmacokinetics and Efficacy
- Total Knee Arthroplasty Outcomes
- Nosocomial Infections in ICU
- Orthopedic Infections and Treatments
- SARS-CoV-2 and COVID-19 Research
- Antibiotic Use and Resistance
- Orthopaedic implants and arthroplasty
- Enterobacteriaceae and Cronobacter Research
- COVID-19 Clinical Research Studies
- Inflammasome and immune disorders
- Plant Pathogens and Fungal Diseases
- Viral gastroenteritis research and epidemiology
- Neonatal and Maternal Infections
- Antifungal resistance and susceptibility
- Immune Response and Inflammation
- Biosensors and Analytical Detection
- Long-Term Effects of COVID-19
- Microscopic Colitis
- Phytoplasmas and Hemiptera pathogens
- COVID-19 epidemiological studies
- Urinary Tract Infections Management
Instituto de Investigación Marqués de Valdecilla
2020-2025
Marqués de Valdecilla University Hospital
2020-2025
Universidad de Cantabria
2020-2025
Ocní klinika
2013
Complejo Hospitalario de Salamanca
2012
Max Perutz Labs
2004-2008
University of Vienna
2004-2008
Vienna Biocenter
2004
Summary The capacity of pathogens to cause disease depends strictly on the regulated expression their virulence factors. In this study, we demonstrate that untranslated mRNA recently described streptococcal p leiotropic e ffect l ocus ( pel ), which incidentally contains sagA , structural gene for streptolysin S, is an effector factor in group A beta‐haemolytic streptococci (GAS). Our data suggest regulation by RNA occurs at both transcriptional (e.g. emm sic nga ) and post‐transcriptional...
Bacterial pathogens are recognized by the innate immune system through pattern recognition receptors, such as Toll-like receptors (TLRs). Engagement of TLRs triggers signaling cascades that launch responses. Activation MAPKs and NF-κB, elements major pathways induced TLRs, depends in most cases on adaptor molecule MyD88. In addition, Gram-negative or intracellular bacteria elicit MyD88-independent results production type I interferon (IFN). Here we show mouse macrophages, activation...
Livestock-associated (LA)-CC398-MRSA is closely related to pigs, being unfrequently detected in human invasive infections. CC398-MSSA emerging infections some countries, but genetic and epidemiological characteristics are still scarcely reported.To determine the prevalence of Staphylococcus aureus (SA) CC398, both MRSA MSSA, among blood cultures SA isolates recovered Spanish hospitals located regions with different pig-farming densities (PD) characterize isolates.One thousand twenty-two (761...
Carbapenem-resistant pathogens have been recognized as a health concern they are both difficult to treat and detect in clinical microbiology laboratories. Researchers making great efforts develop highly specific, sensitive, accurate, rapid diagnostic techniques, required prevent the spread of these microorganisms improve prognosis patients. In this context, CRISPR-Cas systems proposed promising tools for development methods due their high specificity; Cas13a endonuclease can discriminate...
Cefiderocol is a novel siderophore-conjugated cephalosporin developed for the treatment of multidrug-resistant Gram-negative bacterial (GNB) infections. However, current gold standard cefiderocol susceptibility testing, broth microdilution (BMD) using iron-depleted cation-adjusted Mueller-Hinton broth, presents challenges many microbiology laboratories. In this study, we evaluate real-world performance disc diffusion (DD) and commercial BMD method (ComASP
Abstract Background The luxS /AI-2 signaling pathway has been reported to interfere with important physiological and pathogenic functions in a variety of bacteria. In the present study, we investigated functional role streptococcal system metabolism diverse aspects pathogenicity including adaptation organism stress conditions using two serotypes Streptococcus pyogenes , M1 M19. Results Exposing wild-type isogenic -deficient strains sulfur-limited media suggested limited for activated methyl...
Introduction. The antimicrobial resistance is a significant public health threat, particularly for healthcare-associated infections caused by carbapenem-resistant Gram-negative pathogens which are increasingly reported worldwide. aim of this study was to provide data on the in vitro activity cefiderocol and that commercially available comparator antibiotics against defined collection recent clinical multi-drug resistant (MDR) microorganisms, including carbapenem bacteria collected from...
To determine the prevalence of penicillin susceptibility among MSSA causing bloodstream infections (BSIs) in 16 Spanish hospitals and to characterize penicillin-susceptible (MSSA-PENS) isolates.A total 1011 Staphylococcus aureus isolates were collected from blood cultures during 2018-19 (6-12 months) their 18 antimicrobials was determined. The MSSA-PENS selected examined by PCR presence blaZ gene, other resistance genes lukF/lukS-PV, eta, etb tst. immune evasion cluster (IEC) type also...
Introduction Infections caused by carbapenem-resistant Enterobacterales (CRE) and Pseudomonas aeruginosa , including isolates producing acquired carbapenemases, constitute a prevalent health problem worldwide. The primary objective of this study was to determine the distribution different carbapenemases among carbapenemase-producing (CPE, specifically Escherichia coli Klebsiella pneumoniae Enterobacter cloacae complex, aerogenes ) P. (CPPA) in Spain from January 2014 December 2018. Methods A...
Prosthetic joint infection is a feared complication in total hip arthroplasty. The use of antibiotic-impregnated bone cement the important part preventive and therapeutic strategies. At present number commercial cements are available support their by results experimental trials clinical studies has varied. In relation to this issue we studied essential microbiological pharmacological characteristics VancogenX comparison with gentamicin-loaded used conventionally.Based on previously described...
SARS-CoV-2 is a new strain of b-coronavirus whose rapid spread has generated the current 'coronavirus disease 2019 (COVID-19)', leading to pandemic on 11 March 2020.COVID-19 more severe in populations with associated morbidities, thus it expected that patients end-stage renal under replacement therapy can suffer complications.Within this group, those haemodialysis (HD) are at higher risk infection bevause difficulties executing appropriate isolation measures.These individuals need utilize HD...