A5085085604- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Antibiotic Resistance in Bacteria
- Brucella: diagnosis, epidemiology, treatment
- Syphilis Diagnosis and Treatment
- HIV Research and Treatment
- Galectins and Cancer Biology
- Nosocomial Infections in ICU
- HIV/AIDS drug development and treatment
- Pneumonia and Respiratory Infections
- Antibiotic Use and Resistance
- HIV/AIDS Research and Interventions
- Hepatitis Viruses Studies and Epidemiology
- Monoclonal and Polyclonal Antibodies Research
- Bacterial Infections and Vaccines
- Antibiotics Pharmacokinetics and Efficacy
- Reproductive tract infections research
- Neuroscience of respiration and sleep
- Liver Disease and Transplantation
- Burkholderia infections and melioidosis
- HIV, Drug Use, Sexual Risk
- Streptococcal Infections and Treatments
- Salmonella and Campylobacter epidemiology
- Urinary Tract Infections Management
Universidad de Málaga
1999-2025
Instituto de Investigación Biomédica de Málaga
2023-2025
Hospital Clínico Universitario Virgen de la Victoria
2003-2023
Universidad de Granada
2006
Royal Tropical Institute
2003
Universidad de Navarra
2003
Clinica Universidad de Navarra
2001-2003
Hospital General Universitario de Albacete
2003
Universidad Nacional de Colombia
2001
Czech Academy of Sciences, Institute of Microbiology
1992
Pseudomonas aeruginosa healthcare-associated infections are one of the top antimicrobial resistance threats world-wide. In order to analyze current trends, we performed a Spanish nation-wide high-resolution analysis susceptibility profiles, genomic epidemiology and resistome P. over five-year time lapse.A total 3.180 nonduplicated clinical isolates from two surveys in October 2017 2022 were analyzed. MICs 13 antipseudomonals determined by ISO-EUCAST. Multidrug (MDR)/extensively drug...
Abstract Background & Aims The current definition of the pattern liver injury in hepatotoxicity ( DILI ) is given by R (ratio) value, dividing alanine aminotransferase ALT and alkaline phosphatase ALP upper limits normal at onset. We aimed to explore validity using aspartate AST gamma‐glutamyl transpeptidase GGT as biomarkers hepatocelullar cholestatic damage, respectively, when calculating value. Methods Clinical, laboratory histological data from 588 episodes included Spanish Registry...
ABSTRACT To fulfill the need for a simple and rapid diagnostic test human brucellosis, we used immunochromatographic lateral flow assay format to develop two assays, one detection of Brucella -specific immunoglobulin M (IgM) antibodies IgG antibodies. The values these tests were examined. are shown detect acute, persistent, relapsing disease can be monitor treatment. sensitivity IgM assays calculated combined results is 96%, specificity amounts 99%. requires neither specialized training nor...
A dipstick assay for the detection of Brucella-specific immunoglobulin M (IgM) antibodies was evaluated by studying serological response 133 cultures and or serologically confirmed patients with brucellosis in its different stages along those 34 healthy controls. As regards illness less than 3 months duration, 93.1% tested positive assay, a percentage similar to that obtained standard serum agglutination test (SAT) (92.0%), somewhat lower culture (100%) higher IgM enzyme-linked immunosorbent...
Background and aim: undiagnosed hepatitis C virus (HCV) infection and/or inadequate access to care are barriers the elimination of HCV. Reflex testing has proven facilitate referral care, treatment viral elimination. In this study, a reflex program was implemented in Andalusia its impact on evaluated. Patients methods: an observational, retrospective prospective study performed across diagnostic laboratories responsible for HCV diagnosis southern Spain. After surveying performing testing,...
To evaluate the proficiency of Spanish microbiology laboratories with respect to antimicrobial susceptibility testing (AST) Acinetobacter spp.Eight spp. different resistance mechanisms were sent 48 centres which asked report: (i) AST system used; (ii) MICs; (iii) breakpoints used (CLSI versus EUCAST); (iv) clinical category; and (v) inferred. Minor, major very errors (mE, ME VME, respectively) determined.The greatest percentages discrepancies were: by method: 18.5% Etest, 14.3% Vitek 2...
Abstract Background Since the introduction of direct-acting antivirals, thousands chronic hepatitis C patients have been successfully treated. However, vulnerable populations a higher prevalence virus (HCV) infection and face barriers that impede their access to antivirals. We carried out an HCV microelimination program focused on population groups in Malaga. Methods People drug addiction treatment centers homeless shelters Malaga who participated between October 2020 2021 were included....
We have screened for the incidence of vascular ophthalmological side effects (VOSE) in chronic hepatitis C (CHC) patients undergoing pegylated interferon (peg-IFN) plus ribavirin (RBV) therapy and sought evidence angiogenesis activation. Thirty-four CHC were prospectively evaluated (18 with 180 microg/week peg-IFN-alpha2a 800mg/day RBV 16 1.5 microg/kg/week peg-IFN-alpha2b 800-1,200mg/day RBV). Complete evaluation serum endothelial growth factor (VEGF) levels assessed before at end therapy....
Abstract Background and Aims Drug‐induced liver injury (DILI) presents with a wide phenotypic spectrum requiring an extensive differential diagnosis. Hepatitis E virus (HEV) is not systematically ruled out during acute hepatitis assessment in Spain. The aims of this study were to establish the role HEV infection its presentation patients initially suspected DILI determine anti‐HEV seroprevalence rate. Methods An analysis 265 considered for enrolment Spanish Registry 108 controls normal...
Abstract Background Community-acquired (CA) and healthcare-associated (HCA) infections caused by carbapenemase-producing Enterobacterales (CPE) are not well characterized. The objective was to provide detailed information about the clinical molecular epidemiological features of nosocomial, HCA CA Klebsiella pneumoniae (CP-Kp) Escherichia coli (CP-Ec). Methods A prospective cohort study performed in 59 Spanish hospitals from February March 2019, including first 10 consecutive patients whom...
Background CRF19_cpx is a complex circulating recombination form (CRF) of HIV-1. We describe the characteristics an outbreak variant among treatment-naïve patients in southern Spain. Methods The study was undertaken at Virgen de la Victoria Hospital, reference centre for analysis HIV-1 genotype Malaga (Spain). Subtyping performed through REGA v3.0 and relationship our sequences, themselves regarding other sequences from same variant, defined by phylogenetic analysis. used PhyML program to...
We aimed to describe the Hepatitis A virus (HAV) cases that arose in Malaga (Spain) 2016 and 2017 when European Centre for Disease Prevention Control (ECDC) reported several outbreaks among men who have sex with (MSM). Therefore, we conducted a retrospective study gathering demographic, clinical, immunological data from acute HAV patients attending our hospital between March December 2017. Additionally, VP1/P2A region was amplified serum samples, sequenced, genotyped. finally performed...
The results of a dipstick assay for the detection immunoglobulin M (IgM) to Brucella smooth lipopolysaccharide (S-LPS) correlated with those an enzyme-linked immunosorbent (ELISA) IgM and serum agglutination test (SAT) performed without dithiothreitol. Two sera which were dithiothreitol-sensitive negative shown contain specific IgA. is recommended as simple method detecting antibodies in acute-phase brucellosis patients.
Accurate subtyping of hepatitis C virus genotype 1 (HCV-1) remains clinically and epidemiologically relevant. The Abbott HCV Genotype Plus RUO (GT Plus) assay, targeting the core region, was evaluated as a reflex test to resolve ambiguous HCV-1 results in challenging sample collection. 198 specimens were analysed with GT (38 160 without subtype assigned by RealTime II II) assay 5'NC NS5B regions). Sanger sequencing and/or regions performed 127 assignment II, "not detected" Plus, or mixed...
In 2016, an outbreak of hepatitis A was identified in the Malaga province among patients with specific epidemiological characteristics, which were predominantly males. This is a report 51 subjects acute and mean age 35.7 years, 90% male 55% cases men who had sex other within last two months. Half them required hospitalization for significant coagulopathy at diagnosis no progressed to fulminant failure or encephalopathy. Four ascites time diagnosis. adds those reported United Kingdom...
Introduction Sexually transmitted infections (STI) like Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) have been associated with increased risk of HIV acquisition [ 1 ]. It has also described as a high prevalence asymptomatic CT NG in men who sex (MSM) 2 The aim this study was to know the and/or HIV‐MSM related factors. Materials Methods Prospective cohort follow‐up Malaga (southern Spain) during October 2012–May 2014. Patients an opportunistic event or received active antibiotic...