A5089352391- Neurotransmitter Receptor Influence on Behavior
- Diet, Metabolism, and Disease
- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Nerve injury and regeneration
- Antibiotic Resistance in Bacteria
- Advanced biosensing and bioanalysis techniques
- Birth, Development, and Health
- Biomedical Ethics and Regulation
- Liver Disease Diagnosis and Treatment
- Natural Antidiabetic Agents Studies
- Bacterial Genetics and Biotechnology
- Pancreatic function and diabetes
- Substance Abuse Treatment and Outcomes
- Hepatitis C virus research
- Neurogenesis and neuroplasticity mechanisms
- Digestive system and related health
- Pediatric Hepatobiliary Diseases and Treatments
- Pharmaceutical Economics and Policy
- HIV, Drug Use, Sexual Risk
- Phytase and its Applications
- Health Systems, Economic Evaluations, Quality of Life
- Pancreatitis Pathology and Treatment
- Memory and Neural Mechanisms
Fundación Progreso y Salud
2024
Instituto de Investigación Biomédica de Málaga
2020-2023
Universidad de Málaga
2020-2023
Hospital Regional Universitario de Málaga
2022
Hospital Clínico Universitario Virgen de la Victoria
2021
Complexo Hospitalario Universitario A Coruña
2010
Instituto de Investigación Biomédica de A Coruña
2010
Acinetobacter baumannii is a multidrug-resistant bacterium responsible for nosocomial infections in hospitals worldwide. Study of mutant phenotypes fundamental understanding gene function. The methodologies developed to inactivate A. genes are complicated and time-consuming; sometimes result unstable mutants, do not enable construction double (or more) knockout strains baumannii.We describe here rapid simple method obtaining mutants by replacement via crossover recombination, use PCR product...
Abstract Cognitive reserve (CR) is the capability of an individual to cope with a brain pathology through compensatory mechanisms developed cognitive stimulation by mental and physical activity. Recently, it has been suggested that CR protective role against initiation substance use, consumption patterns decline can improve responses treatment. However, never linked function neurotrophic factors in context alcohol consumption. The present cross-sectional study aims evaluate association...
Abstract Background Since the introduction of direct-acting antivirals, thousands chronic hepatitis C patients have been successfully treated. However, vulnerable populations a higher prevalence virus (HCV) infection and face barriers that impede their access to antivirals. We carried out an HCV microelimination program focused on population groups in Malaga. Methods People drug addiction treatment centers homeless shelters Malaga who participated between October 2020 2021 were included....
The present study characterizes the oral pharmacokinetics of D-Pinitol, a natural insulin mimetic inositol, in human healthy volunteers (14 males and 11 females). D-Pinitol absorption was studied (a) subjects receiving single dose 15 mg/kg (n = 10), or (b) 5 pure 6), (c) as part carbohydrate-containing carob pods-derived syrup with 3.2% (Dose 1600 mg/subject, n 9). received randomly assigned either pod-derived syrup. Blood samples were collected at 0, 15, 30, 45, 60, 90, 120, 180, 240, 360...
Preclinical studies on the effects of abrupt cessation selective serotonin reuptake inhibitors (SSRIs), a medication often prescribed in alcohol use disorder (AUD) patients with depression, results consumption escalation after resuming drinking. However, potential neuroinflammatory component this remains unexplored despite immunomodulatory role serotonin. Here, we utilized rat model 14-daily administration SSRI fluoxetine (10 mg/kg/day) along self-administration deprivation to study...
Maternal malnutrition in critical periods of development increases the risk developing short- and long-term diseases offspring. The alterations induced by this nutritional programming hypothalamus offspring are special relevance due to its role energy homeostasis, especially endocannabinoid system (ECS), which is involved metabolic functions. Since astrocytes essential for neuronal efficiency implicated brain signaling, here we have used a rat model investigate whether moderate caloric...
Adult neurogenesis in rodents is modulated by dopaminergic signaling and inhibited cocaine. However, the sex-specific role of dopamine D1 D2 receptors (D1R, D2R) deleterious effect cocaine on adult has not been described yet. Here, we explored sex differences (a) cell proliferation (5'-bromo-2'-deoxyuridine [BrdU]), (b) neural precursor (nestin), (c) neuronal phenotype (BrdU/β3-tubulin), (d) maturity (NeuN) subventricular zone (SVZ) lateral ventricles striatum mice with genetic deletion...
Abstract Preclinical studies on the effects of abrupt cessation selective serotonin reuptake inhibitors (SSRIs), a medication often prescribed in alcohol use disorder (AUD) patients with depression, results consumption escalation after resuming drinking. However, potential neuroinflammatory component this remains unexplored despite immunomodulatory role serotonin. Here, we utilized rat model 14-daily administration SSRI fluoxetine (10 mg/kg/day) along self-administration deprivation to study...