Federico Becerra-Aparicio
A5082763226- Antibiotic Resistance in Bacteria
- Urinary Tract Infections Management
- Antibiotic Use and Resistance
- Antibiotics Pharmacokinetics and Efficacy
- SARS-CoV-2 and COVID-19 Research
- Biosensors and Analytical Detection
- Hematopoietic Stem Cell Transplantation
- SARS-CoV-2 detection and testing
- Immune Cell Function and Interaction
- Reproductive System and Pregnancy
- Bacterial Identification and Susceptibility Testing
- Helicobacter pylori-related gastroenterology studies
- Enterobacteriaceae and Cronobacter Research
- Acute Myeloid Leukemia Research
- Gut microbiota and health
- Malaria Research and Control
- Mosquito-borne diseases and control
- T-cell and B-cell Immunology
- IL-33, ST2, and ILC Pathways
Instituto Ramón y Cajal de Investigación Sanitaria
2021-2025
Hospital Universitario Ramón y Cajal
2020-2025
Instituto de Salud Carlos III
2021-2024
Centro de Investigación Biomédica en Red
2023
Red Espanola de Investigacion en Patologia Infecciosa
2021
Centre for Biomedical Network Research on Rare Diseases
2018-2020
Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas
2018-2020
Pseudomonas aeruginosa healthcare-associated infections are one of the top antimicrobial resistance threats world-wide. In order to analyze current trends, we performed a Spanish nation-wide high-resolution analysis susceptibility profiles, genomic epidemiology and resistome P. over five-year time lapse.A total 3.180 nonduplicated clinical isolates from two surveys in October 2017 2022 were analyzed. MICs 13 antipseudomonals determined by ISO-EUCAST. Multidrug (MDR)/extensively drug...
Dysbiosis and mucin depletion are related with intestinal barrier dysfunction seems to be an early pathophysiological event in inflammatory bowel disease (IBD). The objective of this work is study these parameters the natural history colitis IL-10 deficient mice (IL-10-/-). Wild type (WT) IL-10-/-. were followed until sacrifice at 3, 5, 10, 20, 57, 70 weeks. Body weight, colonic weight/length ratio vivo permeability registered. Expression adhesion molecules colon was explored by qPCR as...
Abstract Background/Objectives To assess the microbiological and clinical features of Klebsiella pneumoniae healthcare-associated bacteraemia urinary origin (HCA-BUO) in Spain, with a particular focus on third generation cephalosporin-(3GCR-Kp) carbapenem-resistant (CR-Kp) isolates. Methods A total 96 (21.4%, 96/449) K. blood isolates were prospectively collected from patients HCA-BUO (n=443) 12 tertiary-care hospitals Spain (2017-2019). Antimicrobial susceptibility was determined (standard...
We report the emergence of an isolate belonging to sequence type (ST)131-Escherichia coli high-risk clone with ceftazidime-avibactam resistance recovered from a patient bacteremia in 2019. Antimicrobial susceptibility was determined and whole genome sequencing (Illumina-NovaSeq6000) cloning experiments were performed investigate its phenotype. A KPC-3-producing E. susceptible (MIC = 0.5/4 mg/L) non-wild MIC meropenem (8 detected blood culture at hospital admission. Following 10-days standard...
The old antimicrobial nitroxoline is currently repurposed for oral treatment of uncomplicated urinary tract infections (UTIs).To investigate the in vitro activity against carbapenem-resistant Acinetobacter baumannii (CRAb).From an international collection previously well-characterized clinical A. isolates, 34 isolates from sources with different carbapenem-resistance mechanisms were selected. Nitroxoline was analysed broth microdilution (BMD), disc diffusion (DD) and within biofilm model....
Abstract Objectives To assess the microbiological characteristics of Escherichia coli causing healthcare-associated bacteraemia urinary origin (HCA-BUO) in Spain (ITUBRAS-2 project), with particular focus on ESBL producers and isolates belonging to ST131 high-risk clone (HiRC). Clinical outcomes associated infection were investigated. Methods A total 222 E. blood prospectively collected from patients HCA-BUO 12 tertiary-care hospitals (2017–19). Antimicrobial susceptibility...
Hematopoietic Stem and Progenitor Cells are crucial in the maintenance of lifelong production all blood cells. These highly regulated to maintain homeostasis through a delicate balance between quiescence, self-renewal differentiation. However, this is altered during hematopoietic recovery after Cell Transplantation. Transplantation efficacy can be limited by inadequate number, poor homing, low level engraftment, or self-renewal. As recent evidences indicate that estrogens involved regulating...
Healthcare-associated (HCA) infections represent a growing public health problem. The aim of this study was to compare community-onset healthcare associated (CO-HCA) bacteremic urinary tract (BUTI) and hospital-acquired (HA)-BUTI with special focus on multidrug resistances (MDR) outcomes.ITUBRAS-project is prospective multicenter cohort patients HCA-BUTI. All consecutive hospitalized adult CO-HCA-BUTI or HA-BUTI episode were included in the study. Exclusion criteria were: < 18 years old,...
Abstract Importance The actual demand on SARS-CoV-2 diagnosis is a current challenge for clinical laboratories. Sample pooling may help to ameliorate workload in Objective evaluate the efficacy of sample compared individual analysis CoVID-19, by using different commercial platforms nucleic acid extraction and amplification. Design settings observational, prospective, multicentre study across 9 Spanish microbiology laboratories including RNA testing performed April 2020, during first three...