A5033284837- COVID-19 Clinical Research Studies
- Antibiotic Resistance in Bacteria
- Antibiotic Use and Resistance
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Infective Endocarditis Diagnosis and Management
- Antibiotics Pharmacokinetics and Efficacy
- Urinary Tract Infections Management
- COVID-19 and healthcare impacts
- Infectious Diseases and Tuberculosis
- Liver Disease Diagnosis and Treatment
- Pneumonia and Respiratory Infections
- Hepatitis C virus research
- Bacterial Infections and Vaccines
- Liver Disease and Transplantation
- Cardiac pacing and defibrillation studies
- Bacterial Identification and Susceptibility Testing
- Electrolyte and hormonal disorders
- Antimicrobial Resistance in Staphylococcus
- Trace Elements in Health
- Gut microbiota and health
- COVID-19 diagnosis using AI
- Health and Medical Research Impacts
- Machine Learning in Healthcare
- Sepsis Diagnosis and Treatment
Hospital Del Mar
2021-2025
Universitat Pompeu Fabra
2018-2025
Centro de Investigación Biomédica en Red
2023-2025
Instituto de Salud Carlos III
2020-2025
Hospital del Mar Research Institute
2018-2024
Universitat Autònoma de Barcelona
2018-2022
Municipal Institute for Medical Research
2021
Centro Nacional de Epidemiología
2020
Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable
2020
Hospital Universitario Virgen Macarena
2016-2018
ObjectivesThe objective of this study was to estimate the association between tocilizumab or corticosteroids and risk intubation death in patients with coronavirus disease 19 (COVID-19) a hyperinflammatory state according clinical laboratory parameters.MethodsA cohort performed 60 Spanish hospitals including 778 COVID-19 data indicative state. Treatment mainly tocilizumab, an intermediate-high dose (IHDC), pulse (PDC), combination therapy, no treatment. Primary outcome death; follow-up 21...
Zinc is an essential micronutrient that impacts host-pathogen interplay at infection. balances immune responses, and also has a proven direct antiviral action against some viruses. Importantly, zinc deficiency (ZD) common condition in elderly individuals with chronic diseases, two groups increased risk for severe coronavirus disease 2019 (COVID-19) outcomes. We hypothesize serum content (SZC) influences COVID-19 progression, thus might represent useful biomarker.
This study aimed to assess the impact of extensively drug-resistant (XDR) phenotype on mortality in Pseudomonas aeruginosa bacteremia. A retrospective cohort was performed a tertiary hospital from January 2000 December 2018. All consecutive prospectively recorded P. bacteremia adult patients were assessed. In this study, 382 included, which 122 (31.9%) due XDR aeruginosa. Independent factors associated with 14-day as follows: high-risk source (hazard ratio (HR) 3.07, 95% confidence interval...
Ceftazidime-avibactam (CZA) has emerged as a promising solution to the lack of new antibiotics against Pseudomonas aeruginosa infections. Data from in vitro assays CZA combinations, however, are scarce. The objective our study was perform time-kill analysis effectiveness alone and combination with other collection extensively drug-resistant (XDR) P. isolates. Twenty-one previously characterized representative XDR isolates were selected. Antibiotic susceptibility tested by broth...
Abstract Background Acute skin and soft tissue infections (ASSTIs) represent a common reason for attending emergency department (ED) hospitalization. We investigate characteristics of cohort ASSTIs-patients comparing patients managed with hospitalization versus outpatients. Methods Retrospective study all consecutive adults who consulted to an ED due ASSTIs. Setting: Hospital del Mar (Barcelona, Spain). Period: January 2018–December 2020. Sample size (320) was calculated detect 10%...
The POET trial demonstrated that moving from intravenous to oral antibiotics in stable patients with left-sided infective endocarditis (IE) was noninferior fully parenteral treatment. However, it did not compare outpatient strategies. OraPAT-IE GAMES is a noninferiority, multicenter, randomized, open-label study aimed partial versus antibiotic therapy (OPAT) for consolidation of treatment IE. A total 342 IE caused by selected micro-organisms will eventually be included. After minimum 10 days...
CD4/CD8 ratio has been used as a quantitative prognostic risk factor in patients with viral infections. This study aims to assess the association between in-hospital mortality and at admission among individuals acute SARS-CoV-2 infection.This is longitudinal cohort data of all consecutive admitted COVID-19 unit Hospital del Mar, Barcelona, Spain for ≥48 h March May 2020. The CD4+ CD8+ T-cell subset differentiation was assessed by flow cytometry well complete blood test. Patients were...
A liver stiffness below 21 kPa has a high negative predictive value to exclude the presence of esophageal varices at risk bleeding in HIV/hepatitis C virus (HCV)-coinfected patients. Consequently, upper gastrointestinal endoscopy (UGE) for screening could be avoided these However, this strategy not been widely accepted due concerns about its safety.To assess ability predict portal hypertensive (PHGB) HIV/HCV-coinfected patients with compensated cirrhosis.Prospective study 446 new diagnosis...
Serum albumin levels have been associated with prognosis in several conditions among older adults. The aim of this study is to assess the prognostic value mortality serum adults SARS-CoV-2 infection. Methods. Cohort observational consecutive older-adults (≥65 years old), confirmed infection admitted a university hospital between March–May 2020. A logistic regression model was fitted impact on in-hospital adjusted by potential confounders. Results. Among total 840 patients hospital, 405 (48%)...
To assess the impact of all-oral direct-acting antiviral agent (DAA) regimens on risk hepatocellular carcinoma (HCC) in HIV/HCV-coinfected patients with cirrhosis.This was a multicentre prospective cohort study recruiting new diagnosis compensated cirrhosis. Patients were followed up until HCC, death or censoring date (March 2017). The primary endpoint emergence HCC. incidence rate (IR) (95% CI) HCC different groups computed. Time-to-event analyses performed to identify predictors...
To evaluate the association between acute-to-chronic (A/C) glycemic ratio and mortality severity outcomes for patients with type 2 diabetes (T2D) hospitalized coronavirus disease 2019 (COVID-19).A total of 91 were included. We measured glycemia at admission estimated average chronic glucose levels to calculate A/C ratio. The primary outcome was a composite in-hospital mortality, intensive care unit admission, mechanical ventilation.Thirty-five had event, presenting significant (hazard [HR]...
This study correlates in vivo findings a patient with an extensively drug-resistant (XDR) P. aeruginosa infection who developed resistance to ceftazidime-avibactam (CAZ-AVI) vitro results of 7-day hollow-fiber model (HFIM) testing the same bacterial strain. The was critically ill ventilator-associated pneumonia caused by XDR ST175 CAZ-AVI MIC 6 mg/L and treated continuous infusion at doses adjusted for renal function. Plasma concentrations were analyzed on days 3, 7, 10. In HIFM, efficacy...
To characterise patients with and without prevalent hypertension COVID-19 to assess adverse outcomes in both inpatients outpatients.
Abstract Purpose To design a randomized clinical trial to assess the efficacy and safety of favipiravir in patients with COVID-19 disease pneumonia. Methods A randomized, double blind, placebo-controlled pneumonia was conducted three Spanish sites. Randomization 1:1 or placebo (in both groups added Standard Care) performed treat The primary endpoint “time improvement,” measured as an improvement for ≥ two categories on 7-point WHO ordinal scale up 28 days' time frame. Results Forty-four were...
Abstract Purpose The aim was to analyse the clinical and economic impact of carbapenemase-producing Enterobacterales (CPE) infections. Methods Case–control study. Adult patients with CPE infections were considered cases, while those non-CPE controls. Matching criteria age (± 5 years), sex, source infection microorganism (ratio 1:2). Primary outcome 30-day mortality. Secondary outcomes 90-day mortality, failure, hospitalisation costs resource consumption. Results 246 (82 cases 164 controls)...
To compare clinical characteristics, outcomes, and resource consumption of patients with coronavirus disease 2019 (COVID-19) seasonal influenza requiring supplemental oxygen.Retrospective cohort study conducted at a tertiary-care hospital. Patients admitted because between 2017 2019, or COVID-19 March May 2020 oxygen were compared. Primary outcome: 30-day mortality. Secondary outcomes: 90-day mortality hospitalization costs. Attempted sample size to detect an 11% difference in was 187 per...
There is little published data on benznidazole dosing, or levels in cerebrospinal fluid. In this report, we describe the clinical course of an immunosuppressed patient with Chagas central nervous system involvement. He was treated successfully larger doses than are recommended, order to reach therapeutically effective concentrations brain.
In April 2015, the Spanish National Health System (SNHS) developed a national strategic plan for diagnosis, treatment, and management of hepatitis C virus (HCV). Our aim was to analyze impact this on human immunodeficiency (HIV)-infected patients included in HERACLES cohort during first 6 months its implementation. The (NCT02511496) set up March 2015 evaluate status follow-up chronic HCV infection co-infected with HIV south Spain. September data were analyzed identify clinical events (death,...