A5088668651- Hematopoietic Stem Cell Transplantation
- Nausea and vomiting management
- Hepatitis C virus research
- Platelet Disorders and Treatments
- Acute Myeloid Leukemia Research
- Cancer Immunotherapy and Biomarkers
- Complement system in diseases
- Chronic Myeloid Leukemia Treatments
- Prostate Cancer Treatment and Research
- Colorectal Cancer Treatments and Studies
- Health Systems, Economic Evaluations, Quality of Life
- Pharmaceutical studies and practices
- Renal Diseases and Glomerulopathies
- Liver Disease Diagnosis and Treatment
- Pharmaceutical Practices and Patient Outcomes
- Renal Transplantation Outcomes and Treatments
- Neutropenia and Cancer Infections
- Polyomavirus and related diseases
- Cytomegalovirus and herpesvirus research
- Anesthesia and Pain Management
- Medication Adherence and Compliance
- Peptidase Inhibition and Analysis
- Lung Cancer Treatments and Mutations
- Sexual function and dysfunction studies
- Muscle and Compartmental Disorders
Hospital Clínic de Barcelona
2020-2025
Universitat de Barcelona
2023
Parc de Salut
2020-2022
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2022
Hospital Universitari de Vic
2020
Universitat Pompeu Fabra
2018
Hospital del Mar Research Institute
2018
Universitat Autònoma de Barcelona
2018
Hospital Del Mar
2017
Trastuzumab emtansine (T-DM1) is approved for the treatment of human epidermal growth factor receptor 2 (HER2)-positive (HER2+) metastatic breast cancer (BC) and residual disease after neoadjuvant therapy; however, not all patients benefit. Here, we hypothesized that heterogeneity in response seen partly explained by levels gene (ERBB2) mRNA. We analyzed ERBB2 expression using a clinically applicable assay formalin-fixed paraffin-embedded (FFPE) tumors (primary or metastatic) from...
Not available.
Abstract Purpose Sex influences chemotherapy-induced nausea and vomiting (CINV). However, in clinical practice, males females receive the same antiemetic prophylaxis. We compared CINV between sexes patients with different emetic risk schemes evaluated predisposing factors main adverse effects caused by antiemetics. Methods Prospective observational study conducted a tertiary-care hospital from February 2023 to May 2024 starting chemotherapy or new treatment line. was using MASCC tool, acute...
Tacrolimus (Tac) is pivotal in preventing acute graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (alloHSCT). It has been reported that genetic factors, including
Identifying polymorphisms in the dihydropyrimidine dehydrogenase (DPYD) gene is gaining importance to be able predict fluoropyrimidine-associated toxicity. The aim of this project was describe frequency DPYD variants DPYD*2A (rs3918290); c.1679T>G (rs55886062); c.2846A>T (rs67376798) and c.1129-5923C>G (rs75017182; HapB3) Spanish oncological patients.Cross-sectional multicentric study (PhotoDPYD study) conducted hospitals located Spain designed register most relevant genetic patients. All...
Our aim was to describe the incidence and characteristics of immune-related adverse events (irAEs) in patients with non-small-cell lung cancer (NSCLC) treated immune checkpoint inhibitors (ICI) evaluate their impact on outcome. All cases NSCLC ICIs second-line setting between December 2015 May 2018 were evaluated. Seventy included. Mean age 65.9 years, majority male (n = 53, 75.7%), PS 0-1 62, 88.6%) nivolumab 51; 72.9%). Thirty-one (44.3%) experienced an AE, 5 (7.1%) grades 3-4. Median OS...
There is little published data on benznidazole dosing, or levels in cerebrospinal fluid. In this report, we describe the clinical course of an immunosuppressed patient with Chagas central nervous system involvement. He was treated successfully larger doses than are recommended, order to reach therapeutically effective concentrations brain.
Tacrolimus (Tac) is a pivotal immunosuppressant agent used to prevent graft-versus-host disease (GVHD) after allogeneic stem cell transplantation (alloHSCT). Tac characterized by narrow therapeutic window and high inter-patient intra-patient pharmacokinetic variability (IPV). Although IPV of concentrations has been associated with adverse post-transplant outcomes following solid organ transplantation, the effects on alloHSCT recipients have not determined. was therefore retrospectively...
Background and aim: Patients with chronic hepatitis C (CHC) frequently associated comorbidities concomitant medication. Sustained virological response (SVR12) has been related to an increase in cholesterol serum levels peripheral vascular resistance. Our aim was evaluate the impact of SVR12 on use medication lipid profile. Methods: Prospective study including patients treated direct-acting antivirals who had achieved SVR12. Clinical data drugs were analysed at baseline least 1 year after...
<h3>Background and Importance</h3> The increased use of monoclonal antibodies (mAb) for cancer treatment has been associated with a higher incidence hypersensitivity reactions (HR). Drug desensitisation is procedure that, by inducing temporary tolerance, allows patients who have developed drug HR to safely receive it. This technique performed according previously published studies plays significant role HR, enabling continuation. <h3>Aim Objectives</h3> To conduct descriptive analysis the...
<h3>Background and Importance</h3> Some oncological treatments are used in special conditions due to the lack of therapeutic alternatives. The use drugs exceptional circumstances or situations (compassionate (CU), off-label (OLU), EMA approved without a refund price country, not included hospital's pharmacotherapeutic guide (non-HPG)) is frequent. These must be by an internal committee at hospital level according Spanish legislation. <h3>Aim Objectives</h3> To analyse requests effectiveness...
To analyse the adverse events (AEs) associated with apalutamide and impact of a multidisciplinary team (MDT) protocol on its management at tertiary care hospital in real-world setting.
Cytomegalovirus (CMV) infection is a relevant cause of morbimortality in patients receiving allogeneic stem cell transplantation (allo-HCT). Foscarnet (FCN) an effective drug against CMV administered intravenously and usually on inpatient basis. The Home Care Unit (HCU) for hematologic at our hospital designed at-home FCN administration model to avoid the hospitalization requiring treatment. This study analyzes whether as safe its administration. We collected compared demographic, clinical,...
Objetivo: El objetivo del estudio es evaluar si la desprescripción de medicamentos considerados bajo valor intrínseco como los condroprotectores o SYSADOA, conlleva un empeoramiento sintomático artrosis, incrementándose el consumo analgésicos. Material y métodos: Siguiendo práctica clínica habitual se retiró tratamiento con SYSADOA a pacientes Centro Atención Primaria (población asignada: 34.382 habitantes, 17% mayores 65 años) en base evidencia científica publicada recomendación...
<h3>Background and Importance</h3> Therapeutic drug monitoring (TDM) of methotrexate (MTX) in plasma is a standard procedure to early identify patients with delayed elimination adjust leucovorin dose. Adequate rescues (LR) should start within 42-48h the beginning high dose (HD)-24h-MTX infusion avoid MTX toxicity but extending LR more than needed can reduce antitumour effect. Before implementation new PETHEMA-2019 protocol at our hospital, were prescribed concentration was determined 48h...
Introduction Chemotherapy-induced nausea and vomiting (CINV) is one of the adverse events that most affects oncologic patients’ quality life. Carboplatin AUC ≥ 4 belongs to agents with high emetic risk (moderate in ASCO guidelines). We aimed compare effectiveness netupitant/palonosetron dexamethasone triple combination (TC) therapy versus ondansetron double (DC) as antiemetic prophylaxis patients carboplatin 4. As a secondary endpoint, TC group we evaluated changing NEPA administration...