A5044665296- Breast Cancer Treatment Studies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- HER2/EGFR in Cancer Research
- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Cancer Genomics and Diagnostics
- Eosinophilic Disorders and Syndromes
- Advanced Breast Cancer Therapies
- Monoclonal and Polyclonal Antibodies Research
- Lymphoma Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Epigenetics and DNA Methylation
- Breast Lesions and Carcinomas
- Cancer Cells and Metastasis
- Chronic Lymphocytic Leukemia Research
- Kruppel-like factors research
- Viral-associated cancers and disorders
- MicroRNA in disease regulation
- Cancer Treatment and Pharmacology
- RNA modifications and cancer
- Cancer-related Molecular Pathways
- Cancer-related gene regulation
- Renal Transplantation Outcomes and Treatments
- Molecular Biology Techniques and Applications
- Hematological disorders and diagnostics
Medizinische Hochschule Hannover
2016-2025
Women‘s Healthcare Group
2023
Research Institute for Philosophy Hannover
2023
Ludwig-Maximilians-Universität München
2017
Krankenhaus vom Roten Kreuz
2017
Universitas Gadjah Mada
2017
German Center for Lung Research
2015
Taipei Institute of Pathology
2003-2013
Center for Rheumatology
2013
Queen Mary University of London
2006
We performed genetic-linkage analysis and candidate-gene sequencing on samples from two unrelated consanguineous families with children who were affected by early-onset inflammatory bowel disease. screened six additional patients colitis for mutations in candidate genes carried out functional assays patients' peripheral-blood mononuclear cells. an allogeneic hematopoietic stem-cell transplantation one patient.
Abstract Ki67 immunohistochemistry (IHC), commonly used as a proliferation marker in breast cancer, has limited value for treatment decisions due to questionable analytical validity. The International Breast Cancer Working Group (IKWG) consensus meeting, held October 2019, assessed the current evidence IHC validity and clinical utility including series of scoring studies IKWG conducted on centrally stained tissues. Consensus observations recommendations are: 1) estrogen receptor HER2...
Trastuzumab-based therapy has been shown to confer overall survival benefit in HER2-positive patients with advanced gastric cancer a large multicentric trial (ToGA study). Subgroup analysis identified adenocarcinomas of the stomach and gastroesophageal (GE) junction overexpression HER2 according immunohistochemistry (IHC) as potential responders. Due recent approval trastuzumab for positive metastatic GE-junction Europe (EMEA) diagnostics is now mandatory IHC being primary test followed by...
Abstract MicroRNAs (miRNAs) represent a new class of small non‐coding RNAs regulating gene expression by inducing RNA degradation or interfering with translation. Aberrant miRNA has been described for several human malignancies and tumour suppressor functions have ascribed to this regulatory RNAs. Accordingly, inactivation due deletion mutation found in malignancies. Here, we describe the role aberrant hypermethylation as an additional mechanism breast cancer. was shown mir‐9‐1, mir‐124a3,...
Adjuvant abemaciclib combined with endocrine therapy (ET) previously demonstrated clinically meaningful improvement in invasive disease-free survival (IDFS) and distant relapse-free (DRFS) hormone receptor-positive, human epidermal growth factor receptor 2-negative, node-positive, high-risk early breast cancer at the second interim analysis, however follow-up was limited. Here, we present results of prespecified primary outcome analysis an additional analysis.This global, phase III,...
Targeted drug delivery with antibody-drug conjugates such as the HER2-directed ado-trastuzumab emtansine (T-DM1) has emerged a powerful strategy for cancer therapy. We show that T-DM1 is particularly effective in eliciting antitumor immunity patients early breast (WSG-ADAPT trial) and HER2-expressing orthotopic tumor model. In latter, despite primary resistance to immunotherapy, combined treatment anti-CTLA-4/PD-1 (cytotoxic T lymphocyte-associated protein-4/programmed cell death protein-1)...
The 21-gene Recurrence Score (RS) assay is a validated prognostic/predictive tool in early hormone receptor-positive breast cancer (BC); however, only few prospective outcome results have been available so far. In the phase III PlanB trial, RS was prospectively used to define subset of patients who received endocrine therapy. We present 3-year data and concordance analysis (among biomarkers/RS).Central tumor bank established from (intermediate high-risk, locally human epidermal growth factor...
Primary immunodeficiencies (PIDs) represent exquisite models for studying mechanisms of human host defense. In this study, we report on two unrelated kindreds, with patients each, who had cryptosporidial infections associated chronic cholangitis and liver disease. Using exome candidate gene sequencing, identified distinct homozygous loss-of-function mutations in the interleukin-21 receptor (IL21R; c.G602T, p.Arg201Leu c.240_245delCTGCCA, p.C81_H82del). The IL-21RArg201Leu mutation causes...
To our knowledge, WSG-ADAPT-HR+/HER2- (ClinicalTrials.gov identifier: NCT01779206; n = 5,625 registered) is the first trial combining 21-gene expression assay (recurrence score [RS]) and response to 3-week preoperative endocrine therapy (ET) guide systemic in early breast cancer.Baseline postendocrine Ki67 (Ki67post) were evaluated centrally. In trial, all patients received exclusively ET: with pathologic regional lymph node status (pN) 0-1 (ie, 0-3 involved nodes) entered control arm if RS...
In recent years an increasing number of cases with polyomavirus (PV)-nephropathy after renal transplantation were reported from several transplant centres. New, highly potent immunosuppressive drugs like tacrolimus or mycophenolate mofetil accused as risk factors for this increase. However, data about the incidence PV-nephropathy in correlation to different therapy concepts are lacking.All biopsies performed at Hannover Medical School between 1999 and 2001 (n=1276) immunohistochemically...
Interstitial calcification has been described in renal allografts, however, the etiology and significance of this finding for graft are unclear. The aim study was to examine serial protocol biopsies, test hypothesis that is related parameters calcium homeostasis these patients analyze a possible relation between function at 1 year. We studied 213 with 586 biopsies obtained 6 weeks, 3 months after transplantation. Calcifications increased over time, from 6.1% weeks 17.8% months. Out patients,...
Abstract Proliferative activity of tumour cells, as assessed by the Ki‐67 labelling index, has been suggested a potential prognostic indicator in many neoplastic diseases. Meaningful application immunohistochemically determined cell growth fraction clinical decision‐making requires information about its inter‐laboratory reproducibility. To assess reproducibility fraction, multi‐centre immunohistochemical trial was performed with 172 participating laboratories, each testing 30 different...
Abstract: Only 20% of patients with chronic hepatitis C (CHC) will develop cirrhosis, and fibrosis progression remains highly unpredictable. A recent genome-wide association study identified a genetic variant in the patatin-like phospholipase-3 (PNPLA3) gene (rs738409 C>G) associated steatosis that was further demonstrated to influence severity nonalcoholic fatty liver disease. The aim this assess impact polymorphism on histological damage response antiviral therapy CHC. We recruited 537...