A5036252189- Glioma Diagnosis and Treatment
- Structural Engineering and Vibration Analysis
- Seismic Performance and Analysis
- Linguistic research and analysis
- CRISPR and Genetic Engineering
- MicroRNA in disease regulation
- Vibration Control and Rheological Fluids
- Advanced X-ray Imaging Techniques
- Linguistic Education and Pedagogy
- CAR-T cell therapy research
- RNA Research and Splicing
- RNA modifications and cancer
- DNA Repair Mechanisms
- Advanced MRI Techniques and Applications
- Advanced X-ray and CT Imaging
- Cancer-related gene regulation
- RNA and protein synthesis mechanisms
- Cancer, Hypoxia, and Metabolism
- Public Administration and Political Analysis
- Brain Metastases and Treatment
- Pluripotent Stem Cells Research
- Protein Kinase Regulation and GTPase Signaling
- Genetic factors in colorectal cancer
- MRI in cancer diagnosis
- Virus-based gene therapy research
Ludwig-Maximilians-Universität München
2016-2025
Massachusetts Institute of Technology
2013-2024
LMU Klinikum
2019-2024
Luxembourg Institute of Science and Technology
2024
Hopp Children's Cancer Center Heidelberg
2020-2023
German Cancer Research Center
2020-2023
Heidelberg University
2020-2023
Technical University of Munich
2014-2023
Deutsche Nationalbibliothek
2023
Software (Spain)
2023
Wiskott-Aldrich syndrome gene therapy is feasible, but γ-retroviral vectors contribute a substantial risk of leukemogenesis.
Abstract microRNAs provide a novel layer of regulation for gene expression by interfering with the stability and/or translation specific target mRNAs. Overall levels are frequently down-regulated in cancer cells, and reducing general microRNA processing increases cancerogenesis transgenic models, suggesting that at least some might act as effectors tumor suppression. Accordingly, suppressor p53 up-regulates miR-34a, contributes to apoptosis acute senescence. Here, we used array hybridization...
Abstract The heart is a central human organ and its diseases are the leading cause of death worldwide, but an in-depth knowledge identity quantity constituent proteins still lacking. Here, we determine healthy proteome by measuring 16 anatomical regions three major cardiac cell types high-resolution mass spectrometry-based proteomics. From low microgram sample amounts, quantify over 10,700 in this high dynamic range tissue. We combine copy numbers per with protein organellar assignments to...
Epigenetic mechanisms and transcription factor networks essential for differentiation of cardiac myocytes have been uncovered. However, reshaping the epigenome these terminally differentiated cells during fetal development, postnatal maturation, in disease remains unknown. Here, we investigate dynamics myocyte development chronic heart failure. We find that prenatal maturation are characterized by a cooperation active CpG methylation histone marks at cis-regulatory genic regions to shape...
Primary immunodeficiencies (PIDs) represent exquisite models for studying mechanisms of human host defense. In this study, we report on two unrelated kindreds, with patients each, who had cryptosporidial infections associated chronic cholangitis and liver disease. Using exome candidate gene sequencing, identified distinct homozygous loss-of-function mutations in the interleukin-21 receptor (IL21R; c.G602T, p.Arg201Leu c.240_245delCTGCCA, p.C81_H82del). The IL-21RArg201Leu mutation causes...
Research Article14 December 2015Open Access Source Data Endothelial cell-derived angiopoietin-2 is a therapeutic target in treatment-naive and bevacizumab-resistant glioblastoma Alexander Scholz Institute of Neurology (Edinger Institute), Goethe University Medical School, Frankfurt, Germany Search for more papers by this author Patrick N Harter German Cancer Consortium (DKTK), Partner Site Frankfurt/Mainz, Sebastian Cremer Burak H Yalcin Stefanie Gurnik Maiko Yamaji Mariangela Di Tacchio...
During all stages of tumor progression, cancer cells are subjected to inappropriate extracellular matrix environments and must undergo adaptive changes in order evade growth constraints associated with the loss attachment. A gain function screen for genes that enable proliferation independently anchorage identified a cell adhesion molecule PVRL4 (poliovirus-receptor-like 4), also known as Nectin-4. promotes anchorage-independence by driving cell-to-cell attachment matrix-independent integrin...
Glioblastoma (GBM) is often treated with the cytotoxic drug temozolomide, but disease inevitably recurs in a drug-resistant form after initial treatment. Here, we report that GBM cells, even modest decrease mismatch repair (MMR) components MSH2 and MSH6 have profound effects on temozolomide sensitivity. RNAi-mediated attenuation of showed such decreases provided an unexpectedly strong mechanism resistance. In mouse xenograft model human GBM, small changes were sufficient to suppress...
Significance Tumor development is accompanied by widespread genomic and transcriptional changes. The mere acquisition of this information has greatly outpaced our capability to functionally study the biological roles altered genes. This dilemma highlights necessity develop technologies that facilitate a rapid functional prioritization among lists Here, we use catalytically dead Cas9 specifically activate or inactivate transcription genes in mouse models cancer. approach allows us impact...
Disorders of the lungs such as chronic obstructive pulmonary disease (COPD) are a major cause morbidity and mortality third leading death in world. The absence sensitive diagnostic tests for early stages COPD results under-diagnosis this treatable an estimated 60–85% patients. In recent years grating-based approach to X-ray dark-field contrast imaging has shown be very detection quantification emphysema small animal models. However, translation technique systems suitable humans remains...
The most powerful adjunct to histopathology for the grading of gliomas seems be metabolic imaging using positron emission tomography and magnetic resonance spectroscopy (MRS). purposes this study were examine feasibility simultaneous acquisition both techniques tumor in a newly launched hybrid (MR-PET) spatial distributions changes gliomas.Twenty-eight consecutive patients with underwent methionine (Met) MR-PET detection malignant part before surgical sampling. After coregistration fusion...
The purpose of this study was to correlate intravoxel incoherent motion (IVIM) imaging with classical perfusion‐weighted MRI metrics in human gliomas. Parametric images for slow diffusion coefficient ( D ), fast *), and fractional perfusion‐related volume f ) patients high‐grade gliomas were generated. Maps F p (plasma flow), v (vascular plasma volume), PS (permeability surface–area product), e (extravascular, extracellular E (extraction ratio), k (influx ratio into the interstitium), t c...
Abstract In regenerative medicine, noncontact manipulation of cells enables new possibilities for tissue engineering. Due to their physicochemical properties, superparamagnetic iron oxide nanoparticles (SPIONs) are used in biomedicine various applications, e.g., as drug transporters, contrast agents or make maneuverable by magnetic forces. SPIONs attached and/or taken up enable targeting adoptive immune therapies Remote control different “magnetized” cell types can be construct multilayered...
Purpose To examine in vivo metabolic alterations the isocitrate dehydrogenase (IDH) mutated gliomas using magnetic resonance spectroscopy (MRS) at field 9.4T. Materials and Methods Spectra were acquired with a 9.4T whole‐body scanner use of custom‐built head coil (16 channel transmit 31 receive). A modified stimulated echo acquisition mode (STEAM) sequence was used for localization. Eighteen patients brain tumors probable glial origin participated this study. The study performed accordance...