A5036932434- Cutaneous Melanoma Detection and Management
- Nonmelanoma Skin Cancer Studies
- Melanoma and MAPK Pathways
- Cutaneous lymphoproliferative disorders research
- melanin and skin pigmentation
- Cancer Immunotherapy and Biomarkers
- Optical Coherence Tomography Applications
- CAR-T cell therapy research
- Genetic and rare skin diseases.
- Immunotherapy and Immune Responses
- Cancer and Skin Lesions
- Skin Protection and Aging
- AI in cancer detection
- Infectious Diseases and Mycology
- Autoimmune Bullous Skin Diseases
- Cell Image Analysis Techniques
- HIV Research and Treatment
- Nail Diseases and Treatments
- Cancer Genomics and Diagnostics
- Drug-Induced Adverse Reactions
- Dermatologic Treatments and Research
- HIV/AIDS drug development and treatment
- Cancer Diagnosis and Treatment
- Urticaria and Related Conditions
- Histiocytic Disorders and Treatments
Instituto de Investigación de Enfermedades Raras
2016-2025
Hospital Clínic de Barcelona
2016-2025
Centre for Biomedical Network Research on Rare Diseases
2016-2025
Instituto de Salud Carlos III
2016-2025
Universitat de Barcelona
2016-2025
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2016-2025
Centro de Investigación Biomédica en Red
2015-2024
Fundació Clínic per a la Recerca Biomèdica
2024
Melanoma Institute Australia
2007-2022
Memorial Sloan Kettering Cancer Center
2014-2022
Recently, TERT promoter mutations were identified at high frequencies in cutaneous melanoma tumor samples and cell lines. The found to have a UV-signature lead increased gene expression. We analyzed large cohort of patients for the presence distribution their association with clinico-pathological characteristics.410 by Sanger sequencing mutations. An analysis associations between mutation status various clinical pathologic variables was performed.TERT 154 (43%) 362 successfully sequenced...
Purpose Primary care physicians (PCPs) constitute an appropriate target for new interventions and educational campaigns designed to increase skin cancer screening prevention. The aim of this randomized study was determine whether the adjunct dermoscopy standard clinical examination improves accuracy PCPs triage lesions suggestive cancer. Patients Methods in Barcelona, Spain, Naples, Italy, were given a 1-day training course detection dermoscopic evaluation, randomly assigned evaluation arm...
<h3>Objectives</h3> To identify in vivo microscopic substrates of the dermoscopic patterns melanocytic lesions and to correlate them with histopathologic features. <h3>Design</h3> Before excision, lesion areas that showed characteristic were imaged by dermoscopy confocal microscopy directly correlated <h3>Setting</h3> Departments Dermatology University Modena Reggio Emilia Hospital Clínico Barcelona, between July 2006 March 2007. <h3>Patients</h3> Patients 202 lesions, corresponding 76...
Journal Article Impact of in vivo reflectance confocal microscopy on the number needed to treat melanoma doubtful lesions Get access I. Alarcon, Alarcon Dermatology Department Melanoma Unit Hospital Clinic & IDIBAPS (Institut d'Investigacions Biomèdiques August Pi i Sunyer) Villarroel 170 Barcelona 08036 Spain Search for other works by this author on: Oxford Academic Google Scholar C. Carrera, Carrera SpainCentro de Investigación Biomédica en Red Enfermedades Raras (CIBERER) J. Palou, Palou...
<h3>Importance</h3> The comparative diagnostic performance of dermoscopic algorithms and their individual criteria are not well studied. <h3>Objectives</h3> To analyze the discriminatory power reliability used in melanoma detection compare accuracy existing algorithms. <h3>Design, Setting, Participants</h3> This was a retrospective, observational study 477 lesions (119 melanomas [24.9%] 358 nevi [75.1%]), which were divided into 12 image sets that consisted 39 or 40 images per set. A link on...
Some recent studies have shown an association between sleep disordered breathing (SDB) and cancer mortality incidence but no study has focused on a specific type of cancer. The objective this was to analyse the relationship severity SDB factors related cutaneous malignant melanoma (CMM) aggressiveness. We performed multicentre observational in 82 consecutive patients diagnosed with CMM. 56 whom measurements were available finally included study. Melanoma aggressiveness included: tumour...
Carrying the cyclin-dependent kinase inhibitor 2A (CDKN2A) germline mutations is associated with a high risk for melanoma. Penetrance of CDKN2A modified by pigmentation characteristics, nevus phenotypes, and some variants melanocortin-1 receptor gene (MC1R), which known to have role in process. However, investigation associations both MC1R host phenotypes melanoma has been limited.We included 815 mutation carriers (473 affected, 342 unaffected, melanoma) from 186 families 15 centers Europe,...
Fluorescence confocal microscopy (FCM) represents a first step toward rapid "bedside pathology" in the Mohs surgery setting and other fields of general pathology.To describe validate FCM criteria for main basal cell carcinoma (BCC) subtypes to demonstrate overall agreement with classic pathologic analysis hematoxylin-eosin-stained samples. DESIGN A total 69 BCCs from 66 patients were prospectively imaged using ex vivo FCM. Confocal mosaics evaluated real time compared analysis.Department...
Abstract Background Longitudinal melanonychia might be difficult to differentiate and the use of dermoscopy can useful for preoperative evaluation management decision. Objectives The aim our study was investigate clinical dermoscopic criteria acquired longitudinal in adults identify best predictors melanoma using a multivariate analysis explore eventual new nail diagnosis. Methods In this retrospective observational study, 82 histopathologically diagnosed, pigmented bands were collected...
Abstract Background Several dermoscopic and in vivo reflectance confocal microscopy ( RCM ) diagnostic criteria of lentigo maligna LM )/lentigo melanoma LMM have been identified. However, no study compared the accuracy these techniques. Objective We evaluated dermoscopy for / using a holistic assessment images. Methods A total 223 facial lesions were by 21 experts. Diagnostic clinical, examination was compared. Interinvestigator variability confidence level diagnosis also evaluated. Results...
Melanomas that clinically mimic seborrheic keratosis (SK) can delay diagnosis and adequate treatment. However, little is known about the value of dermoscopy in recognizing these difficult-to-diagnose melanomas.To describe dermoscopic features SK-like melanomas to understand their clinical morphology.This observational retrospective study used 134 images histopathologically proven patients treated 9 skin cancer centers Spain, France, Italy, Austria. Without knowledge definite for all lesions...
Data on the clinical patterns and histopathology of SARS-CoV-2 related skin lesions, as well their relationship with severity COVID-19 are limited.Retrospective analysis a prospectively collected cohort patients infection in teaching hospital Barcelona, Spain, from 1 April to May 2020. Clinical, microbiological therapeutic characteristics, clinicopathological direct immunofluorescence immunohistochemical findings biopsies were analyzed.Fifty-eight out 2761 (2.1%) either consulting emergency...