Pedro Landete
A5011911722- Obstructive Sleep Apnea Research
- Respiratory Support and Mechanisms
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Neuroscience of respiration and sleep
- SARS-CoV-2 and COVID-19 Research
- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Tracheal and airway disorders
- Pneumothorax, Barotrauma, Emphysema
- Pleural and Pulmonary Diseases
- Airway Management and Intubation Techniques
- Neuroendocrine Tumor Research Advances
- Pneumonia and Respiratory Infections
- Neonatal Respiratory Health Research
- Cardiovascular and Diving-Related Complications
- Respiratory and Cough-Related Research
- Testicular diseases and treatments
- Intensive Care Unit Cognitive Disorders
- COVID-19 diagnosis using AI
- Liver Disease Diagnosis and Treatment
- Sleep and related disorders
- IgG4-Related and Inflammatory Diseases
- Inhalation and Respiratory Drug Delivery
- Occupational Health and Safety Research
Hospital Universitario de La Princesa
2016-2024
Universidad Autónoma de Madrid
2018-2024
Centro de Emergencias Sanitarias 061
2022
Hospital La Luz
2021
Universidad Europea
2021
Hospital Universitario Quirónsalud Madrid
2021
Clinica de Pneumologie Iaşi
2020
National Institute of Health
2020
Universitat de Barcelona
2017
Hospital Universitari Sant Joan D'Alacant
2012-2016
BackgroundPatients with coronavirus disaese 2019 (COVID-19) can develop a cytokine release syndrome that eventually leads to acute respiratory distress requiring invasive mechanical ventilation (IMV). Because IL-6 is relevant in syndrome, the blockade of its receptor tocilizumab (TCZ) could reduce mortality and/or morbidity severe COVID-19.ObjectiveWe sought determine whether baseline serum levels predict need for IMV and response TCZ.MethodsA retrospective observational study was performed...
SARS-CoV-2 is responsible for the development of coronavirus disease 2019 (COVID-19) in infected individuals, who can either exhibit mild symptoms or progress toward a life-threatening acute respiratory distress syndrome (ARDS). Exacerbated inflammation and dysregulated immune responses involving T myeloid cells occur COVID-19 patients with severe clinical progression. However, differential contribution specific subsets dendritic monocytes to ARDS still poorly understood. In addition, role...
Some recent studies have shown an association between sleep disordered breathing (SDB) and cancer mortality incidence but no study has focused on a specific type of cancer. The objective this was to analyse the relationship severity SDB factors related cutaneous malignant melanoma (CMM) aggressiveness. We performed multicentre observational in 82 consecutive patients diagnosed with CMM. 56 whom measurements were available finally included study. Melanoma aggressiveness included: tumour...
Abstract The SARS-CoV-2 is responsible for the pandemic COVID-19 in infected individuals, who can either exhibit mild symptoms or progress towards a life-threatening acute respiratory distress syndrome (ARDS). It known that exacerbated inflammation and dysregulated immune responses involving T myeloid cells occur patients with severe clinical progression. However, differential contribution of specific subsets dendritic monocytes to ARDS still poorly understood. In addition, role CD8 +...
Plitidepsin, a marine-derived cyclic-peptide, inhibits SARS-CoV-2 replication at nanomolar concentrations by targeting the host protein eukaryotic translation elongation factor 1A. Here, we show that plitidepsin distributes preferentially to lung over plasma, with similar potency against across several variants in preclinical studies. Simultaneously, this randomized, parallel, open-label, proof-of-concept study (NCT04382066) conducted 10 Spanish hospitals between May and November 2020, 46...
La infección por SARS-CoV-2 puede favorecer el desarrollo de diversas secuelas respiratorias, sobre todo en los pacientes que han sufrido una neumonía grave COVID-19. Dado elevado número sufrieron esta un corto periodo tiempo, se están llevando a cabo numerosas visitas control post-COVID-19 sin haya establecido protocolo seguimiento clínico aconseje las pruebas complementarias realizar y la frecuencia mismas. Este documento consenso realizado profesionales distintas áreas Sociedad Española...
Plitidepsin has shown potent preclinical activity against severe acute respiratory syndrome coronavirus 2 and was generally well tolerated in a phase I trial of hospitalized patients with disease 2019 (COVID-19). NEPTUNO, III, multicenter, randomized, controlled trial, designed to evaluate the efficacy safety plitidepsin management moderate COVID-19 adult patients.
Abstract Patients with Down syndrome (DS) often have a high occurrence of obstructive sleep apnea‐hypopnea (OSA) syndrome. We studied large cohort adults DS attended due to clinical suspicion OSA. A standardized questionnaire and full medical assessment were conducted, including study. One hundred fifty‐seven individuals studied, mean ± SD age 36 10 years, 40.7% women, BMI 29.4 5.6 kg/m 2 . The main symptom was daytime sleepiness (64.9%). study conducted in 114 patients. All patients...
The main objective of the present study was to analyze both clinical characteristics and evolution during hospitalization a cohort patients admitted for COVID-19 pneumonia who were not vaccinated, or with complete incomplete vaccination schedule.This specialized single-center 1888 hospitalized at "Enfermera Isabel Zendal" Emergencies Hospital (HEEIZ), Madrid (Spain) performed between July 1 September 30, 2021. It compared results 1327 unvaccinated 209 fully vaccinated 352 partially patients....
Nocturnal intermittent hypoxia (IH) featuring obstructive sleep apnea (OSA) dysregulates hepatic lipid metabolism and might contribute to the development of non-alcoholic fatty liver disease (NAFLD) observed in OSA patients. However, further research is required better understanding molecular mechanisms underlying IH-induced accumulation. Therefore, aim present study was determine effects on CD36 expression impact IH by using a mouse model OSA. Histological analysis, content were assessed...
Abstract Plitidepsin is a marine-derived cyclic-peptide that inhibits SARS-CoV-2 replication at low nanomolar concentrations by the targeting of host protein eEF1A (eukaryotic translation-elongation-factor-1A). We evaluated model intervention with plitidepsin in hospitalized COVID-19 adult patients where three doses were assessed (1.5, 2 and 2.5 mg/day for 3 days, as 90-minute intravenous infusion) 45 (15 per dose-cohort). Treatment was well tolerated, only two Grade treatment-related...
Introduction The occurrence of pneumomediastinum (PM) and/or pneumothorax (PTX) in patients with severe pneumonia due to acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was evaluated. Methods This a prospective observational study conducted admitted the intermediate care unit (IRCU) COVID-19 monographic hospital Madrid (Spain) between December 14, 2020 and September 28, 2021. All had diagnosis SARS-CoV-2 required noninvasive support (NIRS): high-flow nasal cannula (HFNC), continuous...