A5054451375- Orthopedic Infections and Treatments
- Infective Endocarditis Diagnosis and Management
- Infectious Diseases and Tuberculosis
- Antimicrobial Resistance in Staphylococcus
- Streptococcal Infections and Treatments
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Hematological disorders and diagnostics
- Long-Term Effects of COVID-19
- COVID-19 and healthcare impacts
- Bacterial Identification and Susceptibility Testing
- Healthcare Systems and Practices
- Pneumonia and Respiratory Infections
- Tuberculosis Research and Epidemiology
- Antifungal resistance and susceptibility
- Innovations in Medical Education
- Pneumocystis jirovecii pneumonia detection and treatment
- Salmonella and Campylobacter epidemiology
- Bacillus and Francisella bacterial research
- Fungal Infections and Studies
- Global Health and Surgery
- Antibiotics Pharmacokinetics and Efficacy
- Osteomyelitis and Bone Disorders Research
- Poxvirus research and outbreaks
- Bacterial Infections and Vaccines
Université de Tours
2016-2025
Centre Hospitalier Universitaire de Tours
2015-2024
Hôpital Bretonneau
2016-2022
Human Genetic of Infectious Diseases
2020
Centre d'Immunologie et des Maladies Infectieuses
2018-2020
Institut Pierre Louis d‘Épidémiologie et de Santé Publique
2020
Sorbonne Université
2012-2020
Inserm
2015-2020
Centre Val de Loire
2020
Hospital for Tropical Diseases
2019
We assessed the determinants of mortality in infective endocarditis (IE), using national hospital discharge databases (HDD) 2011.IE stays were extracted from HDD, with a definition based on IE-related diagnosis codes. This has been according to Duke criteria by checking sample medical charts IE giving predictive positive value 86.1% (95% confidence interval (CI): 82.7% - 89.5%). The impact heart valve surgery survival studied if performed during initial stay, and over year follow-up. Risk...
Abstract Background Enterococcus faecalis infective endocarditis (EFIE) is characterized by a higher frequency of relapses than other endocarditis. The role the treatment on its occurrence remains poorly understood. aim this study was to investigate whether antibiotic regimen could impact risk relapse in EFIE. Materials This multicenter retrospective patients diagnosed with definite EFIE between 2015 and 2019 14 French hospitals. primary endpoint within year following diagnosis. As death...
Severe neurological deficit (SND) is a rare but major complication of pyogenic vertebral osteomyelitis (PVO). We aimed to determine the risk factors and variables associated with clinical improvement for SND during PVO. This case–control study included patients without PVO-associated enrolled in prospective randomized antibiotic duration study, managed 8 French referral centers. Risk were determined by logistic regression. Ninety-seven cases, 297 controls included. epidural abscess [adjusted...
The incidence of pyogenic vertebral osteomyelitis (PVO) has increased over the past two decades. One possible cause this increase is aging population, which results in more comorbidities high income countries.To better characterize clinical presentation and outcome PVO elderly.We conducted a post-hoc analysis previously published trial that studied treatment duration compared outcomes according to age.Our included 351 patients among whom 85 (24%) were 75-years-old or more.There no...
We investigated whether dolutegravir (DTG) monotherapy could be used to maintain virological suppression in people living with human immunodeficiency virus (HIV) on a successful dolutegravir-based triple therapy.MONCAY (MONotherapy of TiviCAY) was 48-week, multicentric, randomized, open-label, 12% noninferiority margin trial. Patients CD4 nadir >100/μL, plasma HIV-1 RNA <50 copies/mL for ≥12 months, and stable regimen DTG/abacavir (ABC)/lamivudine (3TC) were 1:1 randomized continue their or...
Female genital mutilation/cutting (FGM/C) is a prevalent traditional practice affecting over 230 million women globally. Gynaecologists and obstetricians (OB/GYN), midwives, infectious disease (ID) specialists frequently encounter migrant affected by FGM/C. This study aimed to evaluate these caregivers' knowledge, attitudes, practices related The questionnaire, designed an international multidisciplinary team, included 30 questions divided into 5 sections (demographics, practices, attitudes...
Abstract Background Campylobacter spp. bacteremia is a severe infection. A nationwide 5-year retrospective study was conducted to characterize its clinical features and prognostic factors. Methods The included patients with diagnosed in 37 French hospitals participating the surveillance network of National Reference Center for Campylobacters Helicobacters, from 1 January 2015 31 December 2019. goal analyze effects delay appropriate antibiotic therapy other risk factors on 30-day mortality...
ObjectivesThe incidence of acute kidney injury (AKI) in infective endocarditis (IE), its risk factors and consequences on patient renal survival remain debated.MethodsPatients hospitalized for a first episode IE (possible or definite according to modified Duke criteria) between 2013 2016 were included. The primary endpoint was determine early AKI (E-AKI) during the week management IE.ResultsA total 276 patients included: 220 (79.7%) had 56 (20.3%) possible IE. E-AKI occurred 150 (53%). due...
Background Infective endocarditis (IE) caused by non-HACEK gram-negative bacilli (GNB) is poorly characterised and may be emerging as a consequence of medical progress.Methods We performed an observational retrospective case-control study. Cases were GNB IE, definite or possible (modified Duke criteria), diagnosed in adults between 2007 2020 six French referral hospitals. Two controls included for each case (IE due to other bacteria, matched sites diagnosis date).Results Non-HACEK identified...
Summary Background Currently, the biological diagnosis of Pneumocystis jirovecii pneumonia (PjP infection) usually relies on microbiological investigations in bronchial‐alveolar lavage fluid (BALF) by conventional staining methods and/or molecular biology. However, is sometimes complicated to manage, especially weakened patients. Therefore, alternative clinical samples—easier collect—are warranted such specific contexts. Objective Over a four‐year period, diagnostic performance an original...
The choice of the best probabilistic postoperative antibiotics in bone and joint infections (BJIs) is still challenging. Since implementation protocolized linezolid six French referral centers, linezolid-resistant multidrug-resistant Staphylococcus epidermidis (LR-MDRSE) strains were isolated patients with BJI. We aimed here to describe clinical, microbiological, molecular patterns associated these strains. All at least one intraoperative specimen positive for LR-MDRSE between 2015 2020...
Abstract Background Integrase strand transfer inhibitors (INSTIs) are crucial for the treatment of human immunodeficiency virus (HIV) type 2 infection, due to limited available therapeutic options. Recently, bictegravir has been approved HIV-1, but no data currently HIV-2. Methods We assessed phenotypic susceptibility 12 HIV-2 clinical isolates, obtained from antiretroviral-naive and 10 antiretroviral-experienced patients, 5 INSTIs (bictegravir, cabotegravir, dolutegravir, elvitegravir,...
Recurrent urinary tract infections (R-UTIs) are the main cause of morbidity and hospitalizations in subjects with neurogenic bladder (NB) due to spinal cord injury (SCI). We evaluated efficacy weekly oral cyclic antibiotic (WOCA) prophylaxis (ie, alternate administration 2 antibiotics) preventing R-UTIs.Randomized (1:1), open-label, superiority-controlled trial compared WOCA no (control) for 6 months patients NB SCI, using clean intermittent self-catheterization, suffering from R-UTIs....
Patients with X linked agammaglobulinemia are susceptible to enterovirus (EV) infections. Similarly, severe EV infections have been described in patients impaired B-cell response following treatment anti-CD20 monoclonal antibodies (mAbs), mostly those treated for haematological malignancies. We aimed describe receiving mAbs immune-mediated inflammatory diseases (IMIDs).
Plitidepsin has shown potent preclinical activity against severe acute respiratory syndrome coronavirus 2 and was generally well tolerated in a phase I trial of hospitalized patients with disease 2019 (COVID-19). NEPTUNO, III, multicenter, randomized, controlled trial, designed to evaluate the efficacy safety plitidepsin management moderate COVID-19 adult patients.