A5079742329- HIV/AIDS drug development and treatment
- HIV/AIDS Research and Interventions
- Hepatitis C virus research
- HIV Research and Treatment
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Cardiac, Anesthesia and Surgical Outcomes
- HIV-related health complications and treatments
- Enhanced Recovery After Surgery
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Diabetes Management and Research
- Tuberculosis Research and Epidemiology
- Polyomavirus and related diseases
- Colorectal Cancer Surgical Treatments
- Syphilis Diagnosis and Treatment
- Frailty in Older Adults
- Diabetes Treatment and Management
- Hepatocellular Carcinoma Treatment and Prognosis
- SARS-CoV-2 and COVID-19 Research
- Streptococcal Infections and Treatments
- Ocular Diseases and Behçet’s Syndrome
- Hip and Femur Fractures
- Sex work and related issues
Hospital Universitario de Guadalajara
2016-2025
Universidad de Alcalá
2010-2025
Hospital Universitario Severo Ochoa
2022
Centro de Innovación de Infraestructuras Inteligentes (Spain)
2021
Instituto Ramón y Cajal de Investigación Sanitaria
2021
Servicio de Salud de Castilla La Mancha
2010-2019
Univar (United Kingdom)
2018
Sociedad Española de Medicina Interna
2018
Research Institute Hospital 12 de Octubre
2002-2004
American Pharmacists Association
2004
Plitidepsin, a marine-derived cyclic-peptide, inhibits SARS-CoV-2 replication at nanomolar concentrations by targeting the host protein eukaryotic translation elongation factor 1A. Here, we show that plitidepsin distributes preferentially to lung over plasma, with similar potency against across several variants in preclinical studies. Simultaneously, this randomized, parallel, open-label, proof-of-concept study (NCT04382066) conducted 10 Spanish hospitals between May and November 2020, 46...
Abstract Background To understand the effects of frailty, geriatric syndromes, and comorbidity on quality life mortality in older adults with HIV (OAWH). Methods Cross-sectional study FUNCFRAIL multicenter cohort. The setting was outpatient HIV-Clinic. OAWH, 50 year or over were included. We recorded sociodemographic data, infection-related comorbidity, syndromes (depression, cognitive impairment, falls malnutrition), (QOL) estimated risk all-cause 5-year by VACS Index. Association frailty...
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic worldwide, with an incidence that exponentially increasing. Hepatocellular carcinoma (HCC) frequent primary tumor. There increasing relationship between these entities due to potential risk of developing NAFLD-related HCC and prevalence NAFLD. limited evidence regarding prognostic factors at diagnosis HCC. This study compares prognosis in patients NAFLD against other etiologies. It also evaluates patients. For this purpose,...
Hepatocellular carcinoma (HCC) is the most common primary liver tumor and associated with high mortality rates. Approximately 80% of cases occur in cirrhotic livers, posing a significant challenge for appropriate therapeutic management. Adequate screening programs high-risk groups are essential early-stage detection. The extent extrahepatic spread hepatic functional reserve recognized as two influential prognostic factors. In this retrospective multicenter study, we utilized machine learning...
Abstract Background The switching strategy to long-acting cabotegravir and rilpivirine (CAB+RPV) has emerged as a standard approach for people living with HIV (PLWH), offering high efficacy, safety, convenience rates. Nevertheless, there is scarcity of data regarding older PLWH, an important growing population physiological differences arising comorbidities. Methods We conducted multicenter, non-controlled, retrospective study on virologically suppressed individuals who switched CAB+RPV....
The aim of this study is to evaluate the effectiveness an Enhanced Recovery After Surgery Protocol (ERAS) in relation reduce Systemic Inflammatory Response (SIR) surgery using C-reactive protein (CRP) first (POD1), second (POD2) and third (POD3) postoperative day.We enrolled 121 patients (ERAS group) that underwent elective colorectal with ERAS, compared them 135 (preERAS had undergone prior implementation. We made a univariate analysis compare CRP values POD1, POD2, POD3 between...
To compare the clinical, immunologic, and virologic outcomes of efavirenz (EFV)-based versus protease inhibitor (PI)-based highly active antiretroviral therapy (HAART) in severely immunosuppressed HIV-1-infected patients.Retrospective observational cohort study.Responses were analyzed according to intent-to-treat principle among antiretroviral-naive patients with < 100 CD4 cells/muL who started EFV (n = 92) or a PI 218) plus 2 nucleoside reverse transcriptase inhibitors. The primary end...
Abstract Background This study was designed to evaluate if patients with high risk for severe coronavirus disease 2019 (COVID-19) would benefit from treatment tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) followed by baricitinib in case of hypoxemia and systemic inflammation. Methods PANCOVID is an open-label, double-randomized, phase 3 pragmatic clinical trial including adults symptomatic COVID-19 ≥2 comorbidities or aged ≥60 years conducted between 10 October 2020 23 September...
Summary Background Hepatitis B virus (HBV)‐specific CD8 + cell response restoration during nucleos(t)ide analogue (NUC) treatment could lead to off‐treatment HBV control in e‐antigen‐negative chronic hepatitis (CHBe(−)). Aim To predict this with variables involved T‐cell exhaustion for use as a stopping tool. Methods In NUC‐treated CHBe(−) patients, we considered functional cases HBV‐specific cells against core and polymerase epitopes able proliferate secrete type I cytokines after antigen...
Violence against women (VaW) is a widespread crime and violation of the rights women. It present in every country without exception crosses boundaries culture, class, education, income, race. Despite magnitude literature abundance publications on this problem, field lacks comprehensive homogeneous way to measure compare extent VaW across countries. Proper quantification problem needed develop preventive policies strategies reduce it. This article develops an index (VAWI) with global scope...
Plitidepsin has shown potent preclinical activity against severe acute respiratory syndrome coronavirus 2 and was generally well tolerated in a phase I trial of hospitalized patients with disease 2019 (COVID-19). NEPTUNO, III, multicenter, randomized, controlled trial, designed to evaluate the efficacy safety plitidepsin management moderate COVID-19 adult patients.
Background The main international guidelines indicate DTG/3TC therapy as one of the preferred regimens for people living with HIV (PLWH), due to its observed efficacy in randomized clinical trials. However, information real-life cohorts is relatively scarce first-line use. Methods A retrospective multicenter study adult PLWH starting DTG+3TC a regimen before January 31 st , 2020. Virological failure (VF) was defined 2 consecutive RNA viral load (VL) >50 copies/mL. Results 135 participants...
Current antiretroviral therapies (ARTs) have improved outcomes for people living with HIV. However, the requirement to adhere lifelong daily oral dosing may be challenging some HIV, leading suboptimal adherence and therefore reduced treatment effectiveness. Treatment long-acting (LA) ART improve health-related quality of life. The objective this study was evaluate cost-effectiveness cabotegravir + rilpivirine (CAB+RPV) LA administered every 2 months (Q2M) compared current as single-tablet...
Background People in their fifties with HIV are considered older adults, but they appear not to be a homogeneous group. Objective To evaluate the differences among adults according chronological age and year of diagnosis. Methods Cross-sectional study FUNCFRAIL cohort. Patients 50 or over were included stratified by both diagnosis: before 1996 (long-term survivors [LTHS]) after 1996. We recorded sociodemographic data, HIV-related factors, comorbidities, frailty, physical function, other...
proton pump inhibitors (PPIs) block the H+/K+ ATPase enzyme in gastric wall cells, leading to an inhibition of both baseline and stimulated acid secretion. Appropriate indications include: Gastroesophageal reflux, acute upper gastrointestinal bleeding, erosive gastritis or esophagitis, dyspepsia, NSAID-related gastropathy, stress ulcer prophylaxis high risk patients. The aims this study were review current PPIs, evaluate their use Guadalajara s University Hospital.a transversal, analytic,...
Dolutegravir plus lamivudine (2-DR) is suggested as an initial and switch option in HIV-1 treatment. The aim of this study was to analyze the effectiveness, durability, safety 2-DR compared bictegravir/emtricitabine/tenofovir alafenamide (3-DR).
Violence against Women (VaW) has come to be recognized as a serious human rights abuse with important consequences not only for women but whole societies. Since VaW several manifestations, it is possible differentiate among different types of violence. In this article, broad theoretical framework dimensions gender violence was adapted Latin American social and cultural context measure three out the five main violence: economic violence, emotional psychological coercive control. The goal...