A5102901782- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- COVID-19 epidemiological studies
- SARS-CoV-2 detection and testing
- Immune Response and Inflammation
- interferon and immune responses
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Long-Term Effects of COVID-19
- Mosquito-borne diseases and control
- CAR-T cell therapy research
- Influenza Virus Research Studies
- Respiratory viral infections research
- Monoclonal and Polyclonal Antibodies Research
- Infection Control and Ventilation
- Animal Disease Management and Epidemiology
- vaccines and immunoinformatics approaches
- Immune Cell Function and Interaction
- Biosensors and Analytical Detection
- Hepatitis B Virus Studies
- Melanoma and MAPK Pathways
- Respiratory Support and Mechanisms
- Entomopathogenic Microorganisms in Pest Control
The University of Texas MD Anderson Cancer Center
2023-2025
Centre de Recerca en Sanitat Animal
2019-2024
Universitat Autònoma de Barcelona
2020-2024
Queen Mary University of London
2024
Washington State University
2024
Charité - Universitätsmedizin Berlin
2024
German Center for Infection Research
2024
University of Nairobi
2024
University of Edinburgh
2024
University of Hong Kong
2023
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent of COVID-19, is considered a zoonotic pathogen mainly transmitted human to human. Few reports indicate that pets may be exposed virus. The present report describes cat suffering from severe distress and thrombocytopenia living with family several members affected by COVID-19. Clinical signs prompted humanitarian euthanasia detailed postmortem investigation assess whether COVID-19-like disease was causing...
Abstract The protective effect of neutralizing antibodies in SARS-CoV-2 infected individuals is not yet well defined. To address this issue, we have analyzed the kinetics antibody responses and their association with disease severity. Between March May 2020, prospective KING study enrolled 72 COVID-19+ participants grouped according to infection was diagnosed by serological virological tests. Plasma were assessed against replicative virus pseudoviral particles. Multiple regression...
To date, no evidence supports the fact that animals play a role in epidemiology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causative agent infectious disease 2019 (COVID-19). However, several animal species are naturally susceptible to SARS-CoV-2 infection. Besides pets (cats, dogs, Syrian hamsters, and ferrets) farm (minks), different zoo have tested positive for (large felids non-human primates). After summer 2020, second wave infection occurred Barcelona (Spain),...
Plitidepsin, a marine-derived cyclic-peptide, inhibits SARS-CoV-2 replication at nanomolar concentrations by targeting the host protein eukaryotic translation elongation factor 1A. Here, we show that plitidepsin distributes preferentially to lung over plasma, with similar potency against across several variants in preclinical studies. Simultaneously, this randomized, parallel, open-label, proof-of-concept study (NCT04382066) conducted 10 Spanish hospitals between May and November 2020, 46...
Conventional piglets were inoculated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) through different routes, including intranasal, intratracheal, intramuscular and intravenous ones. Although not susceptible to SARS-CoV-2 lacked lesions or viral RNA in tissues/swabs, seroconversion was observed pigs parenterally (intramuscularly intravenously).
Reinfections with SARS-CoV-2 have already been documented in humans, although its real incidence is currently unknown. Besides having a great impact on public health, this phenomenon raises the question of immunity generated by single infection sufficient to provide sterilizing/protective subsequent re-exposure. The Golden Syrian hamster manageable animal model explore immunological mechanisms able counteract COVID-19, as it recapitulates pathological aspects mild moderately affected...
There is an urgent need to identify therapeutics for the treatment of Coronavirus disease 2019 (COVID-19). Although different antivirals are given clinical management SARS-CoV-2 infection, their efficacy still under evaluation. Here, we have screened existing drugs approved human use in a variety diseases, compare how they counteract SARS-CoV-2-induced cytopathic effect and viral replication vitro. Among potential 72 tested herein that were previously proposed inhibit only 18 % had IC 50...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes disease, but it can also affect other organs including the central nervous system. Several animal models have been developed to address different key questions related Coronavirus Disease 2019 (COVID-19). Wild-type mice are minimally susceptible certain SARS-CoV-2 lineages (beta and gamma variants), whereas hACE2-transgenic succumb develop a fatal neurological disease. In this article, we aimed chronologically characterize...
Current COVID-19 vaccines have been associated with a decline in infection rates, prevention of severe disease, and decrease mortality rates. However, SARS-CoV-2 variants are continuously evolving, development new accessible is essential to mitigate the pandemic. Here, we present data on preclinical studies mice receptor-binding domain (RBD)-based recombinant protein vaccine (PHH-1V) consisting an RBD fusion heterodimer comprising B.1.351 B.1.1.7 formulated SQBA adjuvant, oil-in-water...
Background: Cross-reactivity against human coronaviruses with Flebogamma® DIF and Gamunex®-C, two available intravenous immunoglobulins (IVIG), has been reported. In this study, these IVIG were tested for neutralization activity severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), SARS-CoV Middle East CoV (MERS-CoV). Materials & methods: Neutralization capacity of lots manufactured prior to COVID-19 pandemic was assessed viruses in cell culture. Infectivity quantified by percent...
Abstract Middle East respiratory syndrome coronavirus (MERS-CoV) is endemic in dromedaries Africa, but camel-to-human transmission limited. Sustained 12-month sampling of a Kenya abattoir hub showed biphasic MERS-CoV incidence; peak detections occurred October 2022 and February 2023. Dromedary-exposed workers (7/48) had serologic signs previous exposure.
IMCnyeso, an immune mobilizing monoclonal T cell receptor against cancer (ImmTAC) bispecific (New York esophageal squamous carcinoma [NY-ESO]×CD3) engager, targets NY-ESO-1/L-antigen family member-1 isoform A (LAGE-1A) peptide presented by histocompatibility leukocyte antigen (HLA)-A∗02:01. In this phase 1 study, 28 HLA-A∗02:01+ patients with advanced NY-ESO-1/LAGE-1A-positive tumors (n = 28) receive IMCnyeso weekly intravenously (dose range: 3-300 μg; 7 dose-escalation cohorts). The primary...
The ongoing Middle East respiratory syndrome coronavirus (MERS-CoV) outbreaks pose a worldwide public health threat. Blocking MERS-CoV zoonotic transmission from dromedary camels, the animal reservoir, could potentially reduce number of primary human cases. Here we report experimentally infected llamas to naïve animals. Directly inoculated shed virus for at least 6 days and infect all in-contact animals 4–5 after exposure. With aim block transmission, examined efficacy recombinant spike...
Several cases of naturally infected dogs with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been reported despite the apparently low susceptibility this species. Here, we document first case infection caused by Delta (B.1.617.2) variant concern (VOC) in a dog Spain that lived several household members suffering from Coronavirus Infectious Disease 2019 (COVID-19). The animal displayed mild digestive and clinical signs had viral load oropharyngeal swab collected at...
The pandemic caused by the new coronavirus SARS-CoV-2 has made evident need for broad-spectrum, efficient antiviral treatments to combat emerging and re-emerging viruses. Plitidepsin is an antitumor agent of marine origin that also shown a potent pre-clinical efficacy against SARS-CoV-2. targets host protein eEF1A (eukaryotic translation elongation factor 1 alpha) affects viral infection at early, post-entry step. Because electron microscopy valuable tool study virus-cell interactions...
Abstract Background The current standard for COVID-19 diagnosis, RT-qPCR, has important drawbacks its use as a tool epidemiological control, including the need of laboratory-processing, high cost, and long turnaround from sampling to results release. Antigen-based rapid diagnostic tests (Ag-RDT) provide promising alternative this purpose. Methods We assessed analytical clinical performance Ag-RDT Panbio Ag Test (Abbott), using RT-qPCR reference test. was nasopharyngeal swabs, collected in...
With the spread of new variants severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), there is a need to assess protection conferred by both previous infections and current vaccination. Here we tested neutralizing activity infected and/or vaccinated individuals against pseudoviruses expressing spike original SARS-CoV-2 isolate Wuhan-Hu-1 (WH1), D614G mutant B.1.1.7 variant. Our data show that parameters natural infection (time from nature infecting variant) determined...
The spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) since 2019 has made mask-wearing, physical distancing, hygiene, and disinfection complementary measures to control virus transmission. Especially for health facilities, we evaluated the efficacy an UV-C autonomous robot inactivate SARS-CoV-2 desiccated on potentially contaminated surfaces. ASSUM (autonomous sanitary sterilization ultraviolet machine) was used in experimental box simulating a hospital intensive care...
While MERS-CoV (Middle East respiratory syndrome Coronavirus) provokes a lethal disease in humans, camelids, the main virus reservoir, are asymptomatic carriers, suggesting crucial role for innate immune responses controlling infection. Experimentally infected camelids clear infectious within one week and mount an effective adaptive response. Here, transcription of response genes was monitored tract alpacas. Concomitant to peak infection, occurring at 2 days post inoculation (dpi), type I...
ABSTRACTMiddle East respiratory syndrome coronavirus (MERS-CoV) continues infecting humans and dromedary camels. While MERS-CoV strains from the Middle region are subdivided into two clades (A B), all contemporary epidemic viruses belong to clade B. Thus, B may display adaptive advantages over A in and/or reservoir hosts. To test this hypothesis vivo, we compared an early strain (EMC/2012) with a (Jordan-1/2015) alpaca model monitoring virological immunological parameters. Further,...