A5084404678- Systemic Sclerosis and Related Diseases
- Dermatologic Treatments and Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Eosinophilic Disorders and Syndromes
- Skin and Cellular Biology Research
- Meningioma and schwannoma management
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Urticaria and Related Conditions
- Systemic Lupus Erythematosus Research
- Hepatitis C virus research
- Bone Tumor Diagnosis and Treatments
- Head and Neck Surgical Oncology
- Lymphoma Diagnosis and Treatment
- Neonatal Respiratory Health Research
- Asthma and respiratory diseases
- Inflammatory Myopathies and Dermatomyositis
- Chronic Lymphocytic Leukemia Research
- HIV/AIDS drug development and treatment
- Rheumatoid Arthritis Research and Therapies
- Liver Disease Diagnosis and Treatment
- Chemotherapy-related skin toxicity
- Medical Imaging and Pathology Studies
- Cutaneous lymphoproliferative disorders research
- Spinal Dysraphism and Malformations
- T-cell and Retrovirus Studies
Hospital Marina Baixa
2025
Pontifícia Universidade Católica do Paraná
2022
Hospital Universitário Evangélico de Curitiba
2014-2022
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2006-2022
Universidade Presbiteriana Mackenzie
2021
Hospital Universitario Miguel Servet
2019
Instituto de Investigación Biomédica de A Coruña
2018
Complexo Hospitalario Universitario A Coruña
2018
Harvard University Press
2015
Bristol-Myers Squibb (Germany)
2013
Abstract Background The switching strategy to long-acting cabotegravir and rilpivirine (CAB+RPV) has emerged as a standard approach for people living with HIV (PLWH), offering high efficacy, safety, convenience rates. Nevertheless, there is scarcity of data regarding older PLWH, an important growing population physiological differences arising comorbidities. Methods We conducted multicenter, non-controlled, retrospective study on virologically suppressed individuals who switched CAB+RPV....
Rationale: Asthma in children generally starts as being mild but may progress to severe and stay for unknown reasons. Objectives: To identify factors childhood that predict the persistence of asthma late adolescence early adulthood. Methods: The CAMP (Childhood Management Program) is, our knowledge, largest longest trial date; it includes 1,041 aged 5–12 years with moderate asthma. We evaluated 682 program participants analyzable data (age, 17–19 yr) adulthood 21–23 yr). Measurements Main...
Recent studies show an association between autoimmune thyroiditis and systemic sclerosis (SSc) suggest that this condition may interfere with the ES phenotype. However these evaluate as a whole none of them specifically addresses Hashimoto's (HT) in SSc.To investigate presence HT SSc patients its possible disease manifestations.Clinical manifestations hypothyroidism, TSH anti-thyroid auto antibodies (anti-TPO. anti TBG TRAb) were studied 56 SSc. compared without thyroiditis.HT was observed...
Calcium gluconate extravasation is a process that can cause serious lesions, such as necrosis and calcification of the soft tissues. The aim present study was to analyze beneficial effects four possible local antidotes for calcium extravasation: hyaluronidase, sodium thiosulfate, triamcinolone acetonide, physiologic saline solution.Seventy-four BALB/c mice were used in study. substances selected use this (4.6 mEq/ml), hyaluronidase (1500 IU/ml), thiosulfate (25%), acetonide (40 mg/ml 0.5...
Cutaneous fibrosis is one of the main features systemic sclerosis (SSc). Recent findings correlated abnormal collagen V (Col V) deposition in dermis with skin thickening and disease activity SSc. Considering that Col an important regulator fibrillogenesis, understanding role first two years SSc (early SSc) can help to determine new targets for future treatments. In this study, we analyzed morphological, ultrastructural molecular α1(V) α2(V) chains expression their coding genes COL5A1 COL5A2...
A artrite idiopática juvenil (AIJ) é uma doença crônica que pode evoluir para incapacidade permanente, necessitando muitas vezes de tratamento agressivo. Enquanto alguns pacientes não respondem ao metotrexato ou imunossupressores, outros os toleram. Nestes casos, o uso dos inibidores fator necrose tumoral (TNF) anti-TNF indicado. Conforme demonstrado por estudos multicêntricos e randomizados, etanercepte apresenta eficácia no controle da doença, com efeito máximo nos primeiros três meses até...
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Introdução: A síndrome de Chiari é malformação subdividida em 4 tipos clássicos e 2 mais atuais. O ponto conexão todas as suas formas clínicas seria a occipitocervical, caracterizada pelo alongamento sentido caudal do tronco encefálico cerebelo até porção cervical da medula espinhal, através forame magno. Os sintomas comuns se relacionam com compressão das estruturas herniadas no Objetivos: Revisar o papel oportunidade tratamento cirúrgico destinado essas malformaçãoes malformações. Método:...
Introduction: Maffucci syndrome is characterized by multiple subcutaneous enchondromas and can be complicated skull base chondrosarcoma, a rare malignant tumor that produces cartilaginous matrix invades the cortical bone medullary tissue. Objective: To review this its correlation with chondrosarcoma. Method: Narrative based on published information material for reading analysis selected from virtual publishers, SciELO, VHL - Virtual Health Library, Pubmed Scopus. Initially, search was...
This study aimed to evaluate the clinical and serological profile in systemic sclerosis (SSc) by comparing females males.This retrospective was conducted with 215 SSc patients (193 females, 22 males; mean age: 50.1±14.5 years; range, 16 88 years) between September 2005 2020. Disease severity calculated Medsger score. Males were compared for markers.Females more frequently had esophageal involvement (p=0.003), telangiectasias (p=0.03), antinuclear antibodies (p=0.04). fingertip scars digital...
Recent studies show an association between autoimmune thyroiditis and systemic sclerosis (SSc) suggest that this condition may interfere with the ES phenotype. However these evaluate as a whole none of them specifically addresses Hashimoto's (HT) in SSc. To investigate presence HT SSc patients its possible disease manifestations. Clinical manifestations hypothyroidism, TSH anti-thyroid auto antibodies (anti-TPO. anti TBG TRAb) were studied 56 compared without thyroiditis. was observed 19.64%...
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Rheumatoid arthritis (RA) and female reproduction have been linked in the literature for decades.Gynecological obstetrical history has studied this context.Herein, we a sample of RA their gynecological/obstetric comparing them with controls, aiming to know influences number pregnancies, menarche, menopause reproductive years onset occurrence disease our region.
To study a sample of rheumatoid arthritis (RA) patients for their gynecological/obstetric history and compare them to controls determine influences on number pregnancies, menarche, menopause reproductive years following RA onset. This is cross-sectional 122 126 controls. Patients were questioned about age menopause, pregnancies abortions. Reproductive calculated as the difference between at menarche. For comparison, we used Mann-Whitney, unpaired t, chi-squared, Spearman tests. The adopted...