A5108743613- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- COVID-19 Clinical Research Studies
- HIV-related health complications and treatments
- Long-Term Effects of COVID-19
- Antimicrobial Resistance in Staphylococcus
- Tuberculosis Research and Epidemiology
- Pneumonia and Respiratory Infections
- Infectious Diseases and Tuberculosis
- Viral Infections and Vectors
- Research on Leishmaniasis Studies
- Orthopedic Infections and Treatments
- Sepsis Diagnosis and Treatment
- Gut microbiota and health
- Diabetic Foot Ulcer Assessment and Management
- Hematological disorders and diagnostics
- SARS-CoV-2 and COVID-19 Research
- Infective Endocarditis Diagnosis and Management
- Antibiotic Resistance in Bacteria
- Ultrasound in Clinical Applications
- Vector-borne infectious diseases
Instituto de Investigación Biosanitaria de Granada
2015-2025
Universidad de Granada
2004-2025
Vall d'Hebron Institut de Recerca
2022
Centro de Investigación Biomédica en Red
2022
Hospital Universitario de Valme
2022
Universidad de Sevilla
2015-2021
Instituto de Biomedicina de Sevilla
2015-2021
Hospital Universitario La Paz
2012-2021
Hospital Universitario Virgen Macarena
2015-2021
Instituto de Salud Carlos III
2021
African trypanosomiasis is a deadly neglected disease caused by the extracellular parasite Trypanosoma brucei. Current therapies are characterized high drug toxicity and increasing resistance mainly associated with loss-of-function mutations in transporters involved import. The introduction of new antiparasitic drugs into therapeutic use slow expensive process. In contrast, specific targeting existing could represent more rapid cost-effective approach for treatment, impacting through reduced...
The objective of this study was to analyse whether there is an association between reduced susceptibility biocides in Acinetobacter baumannii and (i) antimicrobial resistance (co-resistance), (ii) prevalent (epidemic) clones, (iii) changes the fitness or (iv) expression genes related efflux pumps porins. Susceptibility antimicrobials determined 49 clonally unrelated isolates A. baumannii. Biological cost, terms mean generation time, by spectrophotometry. Quantitative real-time RT–PCR used...
The aim of the study was to assess in vitro activity linezolid and daptomycin, alone combination, against three Staphylococcus aureus isolates using a pharmacokinetic/pharmacodynamic (PK/PD) model biofilm for 3 days. One non-clinical methicillin-resistant S. isolate (N315) two clinical were evaluated. Simulated regimens included high-dose daptomycin (10 mg/kg once daily) (600 mg twice daily), combination. Against all strains, neither nor bactericidal biofilm-embedded bacteria (BB)....
Objective: We aimed to characterize non-AIDS events (NAEs) occurring in newly diagnosed HIV-infected patients a contemporary cohort. Methods: The Cohort of the AIDS Research Network (CoRIS) is prospective, multicenter cohort adults antiretroviral naive at entry, established 2004. evaluated incidence and mortality due NAEs through October 2010. Poisson regression was used investigate factors associated with higher NAEs. Results: Overall, 5185 (13.306 person-years follow-up), median age...
Abstract Background and purpose It is currently unknown whether ultrasound transducer differences influence COVID-19 pneumonia images. Our aim was to describe compare the results obtained using convex linear transducers for image acquisition in lung ultrasound. Methods This a single centre prospective cohort study, comparing probes 16 adult patients with SARS-CoV-2 pneumonia. We analysed 12 lung-fields described presence of pleural thickening, irregularity, B-lines, >3 coalescing...
Introduction. The incidence of coinfections and superinfections following SARS-CoV-2 pneumonia has garnered increasing attention, with complications arising from various pathogens, including viruses, bacteria, fungi. Nevertheless, the relationship between COVID-19 tuberculosis (TB) is not fully understood. This study investigates risk factors for post-COVID-19 pulmonary TB in a low prevalence area southeastern Spain, alongside influence on indeterminate results Quantiferon-TB Gold Plus...
Coronavirus disease 2019 (COVID-19) is a respiratory illness caused by severe acute syndrome coronavirus 2 (SARS-CoV-2) that displays great variability in clinical phenotype. Many factors have been described to be correlated with its severity, and microbiota could play key role the infection, progression, outcome of disease. SARS-CoV-2 infection has associated nasopharyngeal gut dysbiosis higher abundance opportunistic pathogens. To identify new prognostic markers for disease, multicentre...
To investigate the epidemiological, clinical and biological features of visceral leishmaniasis (VL) in patients with HIV-1 infection.Retrospective study.Three university hospitals southern Spain.Forty-seven adult VL infection diagnosed between January 1986 November 1991.Forty-five out 47 (96%) cases were last 2 years. Fever (87%), hepatomegaly (74%), splenomegaly (72%) pancytopenia (77%) most common presenting features. Most (79%) strongly immunocompromised when was diagnosed, stage IV...
Trial design The QoLKAMON study evaluated quality of life, efficacy and treatment safety in HIV patients receiving lopinavir/ritonavir monotherapy (MT) versus continuing combined antiretroviral triple with a boosted protease inhibitor (TT). Methods This was 24-week, open-label, multicentre virologically-suppressed HIV-infected participants (N = 225) 2:1 randomization: 146 who switched to MT were compared 79 remained on TT regimen. primary endpoint change patient-reported outcomes life as...
IL-6 is one of the major mediators hyper-inflammatory responses with complex biological functions as it can signal via different modes action. by classical signalling has anti-inflammatory and antibacterial activities, while trans-signalling mediates pro-inflammatory effects. The net effect established multiple factors beyond its absolute concentration. Here, we assess relationship between variables [IL-6, soluble IL-6R (sIL-6R) gp130 (sgp130)] outcomes in a cohort 366 COVID-19 patients....
Severity criteria for community-acquired pneumonia (CAP) have always excluded patients with human immunodeficiency virus (HIV) infection. A 1-yr, multicenter, prospective observational study of HIV-infected bacterial CAP was done to validate the used in American Thoracic Society (ATS) guidelines CAP, and determine prognosis-associated factors population CAP. Overall, 355 cases were included, an attributable mortality 9.3%. Patients who met ATS had a longer hospital stay (p = 0.01), duration...
Cohort studies have shown that highly active antiretroviral therapy (HAART) can improve liver-related mortality in HIV/hepatitis C virus (HCV)-coinfected patients. A reduction the accelerated liver fibrosis progression observed HIV infection induced by HAART could explain these findings. few assessed impact of on fibrosis, but with contradictory results. Therefore, we evaluated associations between use different drug classes and combinations, HIV-infected patients chronic hepatitis C. Six...
Abstract Assessment of HIV tropism using bioinformatic tools based on V3 sequences correlates poorly with results provided by phenotypic assays, particularly for recognizing X4 viruses. This may represent an obstacle the use CCR5 antagonists. An algorithm combining several might improve correlation results. A total 200 from HIV‐1 subtype B, available in databases known results, were used to evaluate sensitivity and specificity seven different (PSSM, SVM, C4.5 decision tree generator C4.5,...