A5050404388- Sperm and Testicular Function
- Reproductive Biology and Fertility
- Reproductive Health and Technologies
- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- Asthma and respiratory diseases
- HIV/AIDS drug development and treatment
- Monoclonal and Polyclonal Antibodies Research
- Transplantation: Methods and Outcomes
- Vector-borne infectious diseases
- Diabetes and associated disorders
- Organ Transplantation Techniques and Outcomes
- T-cell and B-cell Immunology
- Allergic Rhinitis and Sensitization
- Inhalation and Respiratory Drug Delivery
- Viral Infections and Vectors
- Renal Transplantation Outcomes and Treatments
- COVID-19 Clinical Research Studies
- Respiratory and Cough-Related Research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Platelet Disorders and Treatments
- Systemic Lupus Erythematosus Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Food Allergy and Anaphylaxis Research
- Sex work and related issues
Universitat Autònoma de Barcelona
1987-2025
Corporació Sanitària Parc Taulí
2012-2025
Institute of Research and Innovation Parc Tauli
2020-2025
Hospital Universitario Son Espases
2024
Deleted Institution
1994-2012
Bellvitge University Hospital
2001
Universitat de Barcelona
2001
Hospital de Sant Pau
1987-1994
Universidad San Pablo CEU
1989
Consejo Superior de Investigaciones Científicas
1985
Sperm DNA fragmentation (SDF) is becoming an important test to assess male infertility. Several different tests are available, but no consensus has yet been reached as which most predictive of Few publications have reported a comprehensive analysis comparing these methods within the same population. The objective this study was analyze differences between five common methodologies, their correlations and establish cut-off values, sensitivity specificity in predicting We found SDF fertile...
The primary aim of this study was to determine the effect oral antioxidant treatment (1500 mg l-Carnitine; 60 vitamin C; 20 coenzyme Q10; 10 E; zinc; 200 μg B9; 50 selenium; 1 B12) during a time period 3 months upon dynamics sperm DNA fragmentation following varying periods storage (0 h, 2 6 8 h and 24 h) at 37 °C in cohort infertile patients diagnosed with asthenoteratozoospermia. A secondary objective use chromatin dispersion test (SCD) effects specific subpopulation highly degraded (DDS)....
It is known that sperm samples from recurrent pregnancy loss (RPL) couples have an increase in their DNA fragmentation (SDF), but no studies been performed order to identify differences between single stranded SDF (ssSDF) and double (dsSDF) these patients. This could be relevant because the type of damage different effects. Semen were classified attending clinical status: 25 fertile donors 20 RPL patients with at least two unexplained first trimester miscarriages. was analysed using alkaline...
Infertile males with varicocele have the highest percentage of sperm cells damaged DNA, compared to other infertile groups. Antioxidant treatment is known enhance integrity DNA; however, there are no data on effects in patients. We thus investigated potential benefits antioxidant specifically grade I males. Twenty patients were given multivitamins (1500 mg L-Carnitine, 60 vitamin C, 20 coenzyme Q10, 10 E, 200 μg B9, 1 B12, zinc, 50 selenium) daily for three months. Semen parameters including...
BackgroundFactors affecting outcomes of SARS-CoV-2 infection in people living with HIV are unclear. We assessed the factors associated diagnosis and severe among HIV.MethodsWe did a retrospective cohort study using data from PISCIS Catalonia (Spain) between March 1 Dec 15, 2020. linked integrated health-care, clinical, surveillance registries through Public Data Analysis for Health Research Innovation Program (PADRIS) to obtain on diagnosis, chronic comorbidities, as well clinical mortality...
Over the last years, mean age of subjects with HIV infection and AIDS is increasing. Moreover, some epidemiological clinical differences between younger older HIV-infected individuals have been observed. However, since introduction HAART therapy, there are controversial results regarding their response to HAART. The aim present study evaluate features, HAART, survival in elderly patients regard patients. A prospective cohort (1998–2003) was performed on from Sabadell Hospital, Northeast...
The analysis of sperm DNA fragmentation has become a new marker to predict male infertility, and many techniques have been developed. Comet assay offers the possibility differentiating single- double-stranded (ssDNA dsDNA) breaks, which could different effects on fertility. objective this study was perform descriptive characterization groups patients, such as those with asthenoteratozoospermic (ATZ) or without varicocele, oligoasthenoteratozoospermic (OATZ) balanced chromosome...
Summary Sperm cryopreservation is widely used for both research and reproduction purposes, but its effect on sperm DNA damage remains controversial. fragmentation ( SDF ) has become an important biomarker to assess male infertility. In particular, the differentiation between single‐ double‐stranded (ss ds clinical implications infertility where ss associated with reduced fertility, whereas increased risk of miscarriage. this study, semen samples from 30 human males have been analysed in...
To date, no biomarkers have been found that are able to predict the clinical response omalizumab. The aim of this study was assess whether blood concentration free Immunoglobulin E (IgE) can treatment with monoclonal antibody. In a group patients who were candidates for omalizumab treatment, forced spirometry and IgE measured at entry each six-month visit, free-IgE concentrations month 6. At 18, OMADORE protocol applied. complete follow-up lasted 30 months. Patients considered responders if...
Background:Several studies have demonstrated the beneficial effects of omalizumab in asthma patients. Here we describe drug's tolerance and oral corticosteroid sparing capacity a long-term observational study.Methods:Thirty-two patients aged ≥18 years with obstructive airway disease FEV1 reversibility ≥12% 200 mL, an steroid requirement ≥7.5 mg per day prednisolone during period ≥1 year, positive prick test or vitro reactivity (RAST) to at least one perennial aeroallergen baseline...
Purpose . To establish the prevalence of bronchiectasis in asthma relation to patients’ oral corticosteroid requirements and explore whether increased risk is due blood immunoglobulin (Ig) concentration. Methods Case-control cross-sectional study, including 100 sex- age-matched patients, 50 with non-steroid-dependent (NSDA) steroid-dependent (SDA). Study protocol: (a) measurement Ig gG subclass concentration; (b) forced spirometry; (c) high-resolution thoracic computed tomography. When was...
Varicocele is one of the most common causes low semen quality, which reflected in high percentages sperm cells with fragmented DNA. While varicocelectomy usually performed to ameliorate a patient’s fertility, its impact on DNA integrity case subclinical varicocele poorly documented. In this study, multiple fragmentation analyses (TUNEL, SCD, and SCSA) were samples from sixty infertile patients (15 clinical varicoceles, 19 varicoceles after surgical treatment, 16 10 treatment). TUNEL, SCSA...
Several studies have associated telomere shortening with alterations in reproductive function. The objective of the present study was to determine length (TL) spermatozoa selected by either density-gradient centrifugation (DGC) or swim-up. analysis TL performed using quantitative fluorescent situ hybridisation (qFISH) PNA probes combination a chromatin decompaction protocol sperm cells. Results were 24.64 ± 5.00 Kb and 24.95 4.60 before after DGC, respectively, 19.59 8.02 20.22 5.18 swim-up...
Thrombocytopenia is a common haematological abnormality and no simple diagnostic test available to diagnose thrombocytopenia pathogenesis.To evaluate sensitivity specificity of reticulated platelets (RP) as for with increased thrombopoietic activity.Prospective observational study in thrombocytopenic patients.A direct, whole-blood, dual-labelling flow cytometric method was used. Direct, whole-blood double coverage achieved using monoclonal anti-glycoprotein (GP)-III antibody (CD61 PerCP)...
This investigation was conducted to assess the baseline level of sperm DNA fragmentation (SDF) in a cohort patients presenting chromosomal rearrangements (nine reciprocal translocations and two inversions). In separate experiment, dynamic analysis calculate rate SDF (rSDF), after varying period storage (0 h, 1 4 8 h 24 h) at 37 °C, performed. Results were compared with eight fertile donors. Different experimental approaches SDF, such as terminal transferase dUTP nick-end labelling (TUNEL),...
A broader extent of amino acid substitutions in the integrase HIV-2 compared with HIV-1 might enable greater cross-resistance between raltegravir and dolutegravir infection. Few studies have examined virological response to patients that failed raltegravir.All recorded Spanish cohort were examined. The coding region was sequenced viraemic patients. Changes associated resistance recorded.From 319 HIV-2-infected cohort, 53 sequences from 30 individuals obtained (20 naive 10 experienced). Only...
Varicocele is one of the main causes male infertility and microsurgical varicocelectomy (MV) seems to be best procedure for its repair reduce testicular oxidative stress (ROS). As ROS guanine modifications, we postulated that DNA damage could more intense in telomeres due their G-rich nature. We studied effect MV on sperm telomere length (TL), single- double-strand fragmentation (ssSDF dsSDF) seminal parameters. Sperm from 12 fertile donors 20 varicocele patients before nine months after...
COVID-19 pathophysiology and the predictive factors involved are not fully understood, but lymphocytes dysregulation appears to play a role. This paper aims evaluate lymphocyte subsets in of as for severe disease.A prospective cohort study patients with SARS-CoV-2 bilateral pneumonia recruited at hospital admission. Demographics, medical history, data regarding infection were recorded. Patients systematically underwent complete laboratory tests, including parameters related well time Severe...
Although the first clinical descriptions of Bartonella infection were associated with immunocompromised patient bacillary angiomatosis, we currently know that this organism is directly involved in diseases affecting a large number patients, regardless their immune status. Cat scratch disease, hepatic peliosis, and some cases bacteraemia endocarditis, are caused by species genus Bartonella. The purpose study was to determinate prevalence IgG antibodies against henselae B. quintana HIV...
There are no specific criteria for a step-down or withdrawal dose of omalizumab (OMA). Our purpose was to evaluate the viability protocol OMAlizumab DOse REduction (the OMADORE study) in severe allergic asthma (SAA).The study population included 35 SAA patients treated during minimum period 1 year with oral corticosteroids (OC) equivalent mean daily 4 mg methyl-prednisolone. To qualify protocol, had have received treatment OMA at least one and half years, OC reached lowest tolerated...