Carmen Luna
A5000984830- Hepatitis C virus research
- Infective Endocarditis Diagnosis and Management
- Antimicrobial Resistance in Staphylococcus
- Hepatitis B Virus Studies
- Tracheal and airway disorders
- Liver Disease Diagnosis and Treatment
- Streptococcal Infections and Treatments
- HIV/AIDS drug development and treatment
- HIV/AIDS Research and Interventions
- Congenital Diaphragmatic Hernia Studies
- HIV Research and Treatment
- Esophageal and GI Pathology
- Tuberculosis Research and Epidemiology
- Antibiotics Pharmacokinetics and Efficacy
- Social Sciences and Policies
- Diagnosis and treatment of tuberculosis
- Infectious Diseases and Tuberculosis
- Cardiac Valve Diseases and Treatments
- Economic and Social Development
- Vascular Anomalies and Treatments
- Airway Management and Intubation Techniques
- COVID-19 Clinical Research Studies
- Neonatal Respiratory Health Research
- Health and Lifestyle Studies
- Chronic Lymphocytic Leukemia Research
Hospital General Universitario Gregorio Marañón
2021-2024
University of Castilla-La Mancha
2023
Hospital Son Llatzer
2011-2022
Hospital Universitario 12 De Octubre
2012-2021
Universidad de Cantabria
2021
Marqués de Valdecilla University Hospital
2021
Secretaría de Salud de Bogotá
2021
Research Institute Hospital 12 de Octubre
2007-2020
BackgroundFactors affecting outcomes of SARS-CoV-2 infection in people living with HIV are unclear. We assessed the factors associated diagnosis and severe among HIV.MethodsWe did a retrospective cohort study using data from PISCIS Catalonia (Spain) between March 1 Dec 15, 2020. linked integrated health-care, clinical, surveillance registries through Public Data Analysis for Health Research Innovation Program (PADRIS) to obtain on diagnosis, chronic comorbidities, as well clinical mortality...
Although two pegylated interferons (Peg-IFN) are available to treat chronic hepatitis C virus (HCV) infection, no head-to-head comparative studies have been published. We aim compare the efficacy and safety of PEG IFN alfa-2b (PEG 2b) versus alfa-2a 2a), plus ribavirin (RBV). A prospective, randomized, multi-center, open-label clinical trial including 182 human immunodeficiency (HIV)-hepatitis patients naïve for HCV therapy was performed. Patients were assigned 2b (80-150 mug/week; n = 96)...
Summary Objective To report our experience with a new type of biodegradable airway stent in the setting severe tracheobronchial obstruction children. Design and Methodology We conducted retrospective prospective (since June 2014) study pediatric patients treated stents institution between 2012 2015. The following data were collected: demographics, indication for stenting, bronchoscopic findings, insertion technique complications, clinical outcome, related re‐stenting, time follow‐up. Results...
Objective: Tracheobronchial obstruction is infrequent in the pediatric age group but it associated with significant morbidity and mortality. The purpose of this study to review results a single institution experience endoscopic stent placement children benign tracheobronchial obstruction, special concern on safety clinical effectiveness. Materials methods: Twenty-one patients severe airway stenosing disease which was performed between 1993 2006. Inclusion criteria according status were:...
Changes in the indications for tracheostomy children have led to progressively greater involvement of paediatric pulmonologist care these patients. The aim this study was review current profile tracheostomised Spain. We undertook a longitudinal, multicentre over 2 yrs (2008 and 2009) all patients aged between 1 day 18 who had tracheostomy. study, involving Spanish hospitals, included 249 patients, whom 150 (60.2%) were <1 yr age. main procedure prolonged ventilation (n=156, 62.6%),...
Abstract Objectives We assessed the prevalence of anti‐hepatitis C virus (HCV) antibodies and active HCV infection (HCV‐RNA‐positive) in people living with HIV (PLWH) Spain 2019 compared results those four similar studies performed during 2015–2018. Methods The study was 41 centres. Sample size estimated for an accuracy 1%. Patients were selected by random sampling proportional allocation. Results reference population comprised 973 PLWH, sample 1325. serostatus known 1316 PLWH (99.3%), whom...
This study focuses on the different surgical and endoscopical treatment alternatives when dealing with severe complications after slide tracheoplasty (STP).Retrospective of patients symptomatic congenital tracheal stenosis (CTS) admitted to a single institution, between January 1997 2013, surgically treated by means STP. The following variables were evaluated: demographics, preoperative characteristics, associated anomalies outcome measures.Cohort included 14 (8 males 6 females) mean age 8.7...
Reports on the impact of some antiretrovirals against SARS-CoV-2 infection and disease severity are conflicting.We evaluated effect tenofovir as either alafenamide/emtricitabine (TAF/FTC) or disoproxil fumarate/emtricitabine (TDF/FTC) associated clinical outcomes among people living with HIV (PLWH).We conducted a propensity score-matched analysis in prospective PISCIS cohort PLWH (n = 14 978) Catalonia, Spain. We used adjusted Cox regression models to assess association between...
We assessed the prevalence of antibodies against hepatitis C virus (HCV-Abs) and active HCV infection in patients infected with human immunodeficiency (HIV) Spain 2016 compared results those similar studies performed 2002, 2009, 2015.The study was 43 centers during October-November 2016. The sample estimated for an accuracy 2% selected by proportional allocation simple random sampling. During 2016, criteria therapy based on direct-acting antiviral agents (DAA) were at least significant liver...
Background The combination of pegylated interferon (PEG-IFN) plus ribavirin (RBV) is the standard care for hepatitis C virus (HCV) treatment in HIV-coinfected individuals. In 2007, abacavir (ABC)-based antiretroviral therapy was, first time, reported to be associated with early virological failure during HCV treatment. aim our study was evaluate effect ABC on response rate therapy. Methods A retrospective analysis HIV–HCV- coinfected patients treated PEG-IFN and weight-adjusted RBV four...
New direct-acting antiviral agents (DAAs) have shown great efficacy and tolerability in clinical trials real-life cohorts. However, data are scarce regarding safety cirrhotic HCV/HIV-coinfected patients. A multicentre prospective analysis was performed 13 Spanish hospitals, including all patients starting DAA combinations from January to December 2015. Sustained virological response 12 weeks after treatment (SVR12) analysed. Withdrawal due toxicity and/or hepatic decompensation change liver...
Screening strategies based on interferon-γ release assays in tuberculosis contact tracing may reduce the need for preventive therapy without increasing subsequent active disease.We conducted an open-label, randomized trial to test noninferiority of a 2-step strategy with tuberculin skin (TST) followed by QuantiFERON-TB Gold In-Tube (QFT-GIT) as confirmatory (the TST/QFT arm) standard TST-alone (TST targeting household contacts patients tuberculosis. Participants were 24 months after...
Obstructive sleep apnea (OSA) in children is a prevalent, albeit largely undiagnosed disease associated with large spectrum of morbidities. Overnight in-lab polysomnography remains the gold standard diagnostic approach, but time-consuming, inconvenient, and expensive, not readily available many places. Simplified Home Respiratory Polygraphy (HRP) approaches have been proposed to reduce costs facilitate process. However, evidence supporting validity HRP still scarce, hampering its...
To assess the clinical and immunovirological outcomes among naive patients with advanced HIV presentation starting an antiretroviral regimen in real-life settings.This was a multicentre, prospective cohort study. We included all treatment-naive adults disease (CD4+ T cell count < 200 cells/mm3or presence of AIDS-defining illness) who started therapy between 2010 2020. The main were mortality, virological effectiveness (percentage viral load ≤50 copies/mL) immune restoration CD4+ above 350...
Background and Aims This was a safety efficacy pharmacogenetic study of previously performed randomized trial which compared the effectiveness treatment hepatitis C virus infection with pegylated interferon alpha (pegIFNα) 2a vs. 2b, both ribavirin, for 48 weeks, in HCV-HIV coinfected patients. Methods The groups were made 99 patients (efficacy substudy) 114 (safety substudy). Polymorphisms following candidate genes IL28B, IL6, IL10, TNFα, IFNγ, CCL5, MxA, OAS1, SOCS3, CTLA4 ITPA assessed....
Identification of a frameshift heterozygous mutation in the transcription factor NKX2-1 patient with brain-lung-thyroid syndrome (BLTS) and life-threatening lung emphysema. To study genetic defect that causes this complex phenotype dissect molecular mechanism underlying through functional analysis. Mutational by DNA sequencing, generation expression vectors, site-directed mutagenesis, protein–DNA-binding assays, luciferase reporter gene confocal microscopy, coimmunoprecipitation,...
Background Recent and reliable estimates on the prevalence of coinfection with human immunodeficiency virus (HIV) hepatitis B (HBV) in Europe are lacking. Aim Leveraged a study designed to assess HIV/HCV prevalence, we assessed HIV/HBV Spain 2018 compared results five similar studies performed since 2002. Methods This cross-sectional was carried out 43 centres, patients were selected using simple random sampling. The reference population comprised 40,322 sample size 1,690 patients. Results...
Crocetin (CCT) is a natural saffron-derived apocarotenoid that possesses healthy properties such as anti-adipogenic, anti-inflammatory, and antioxidant activities. Lipolysis enhanced in obesity correlates with pro-inflammatory, pro-oxidant state. In this context, we aimed to investigate whether CCT affects lipolysis. To evaluate CCT's possible lipolytic effect, 3T3-L1 adipocytes were treated CCT10μM at day 5 post-differentiation. Glycerol content activity assessed using colorimetric assays....