A5088612128- HIV-related health complications and treatments
- HIV Research and Treatment
- Salivary Gland Disorders and Functions
- Sarcoidosis and Beryllium Toxicity Research
- Systemic Lupus Erythematosus Research
- HIV/AIDS drug development and treatment
- Vasculitis and related conditions
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- IgG4-Related and Inflammatory Diseases
- Pneumocystis jirovecii pneumonia detection and treatment
- Lysosomal Storage Disorders Research
- HIV/AIDS Research and Interventions
- Atherosclerosis and Cardiovascular Diseases
- Liver Disease Diagnosis and Treatment
- Autoimmune and Inflammatory Disorders
- Antifungal resistance and susceptibility
- Neuroendocrine Tumor Research Advances
- Otitis Media and Relapsing Polychondritis
- COVID-19 Clinical Research Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Lymphoma Diagnosis and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Long-Term Effects of COVID-19
- Gastrointestinal disorders and treatments
- Immune Cell Function and Interaction
Hospital Universitari Joan XXIII de Tarragona
2015-2024
Universitat Rovira i Virgili
2013-2023
Institut d'Investigació Sanitària Pere Virgili
2012-2023
Centro de Investigación Biomédica en Red
2022-2023
Instituto de Salud Carlos III
2022-2023
University College London
2022
European League Against Rheumatism
2020
Hospital San Agustin
2020
Creative Commons
2015
Vall d'Hebron Hospital Universitari
2015
The purpose of this study is to characterize the risk cancer in a large cohort patients with primary Sjögren syndrome (SjS).We had analyzed development 1300 consecutive fulfilling 2002 SjS classification criteria. baseline clinical and immunological characteristics systemic activity (ESSDAI scores) were assessed at diagnosis as predictors using Cox proportional hazards regression analysis adjusted for age gender. sex-and age-specific standardized incidence ratios (SIR) estimated from 2012...
The aim of this study was to describe the clinical characteristics ANCA-associated vasculitides (AAV) at presentation, in a wide cohort Spanish patients, and analyze impact vasculitis type, ANCA specificity, prognostic factors, treatments administered diagnosis, outcome. A total 450 patients diagnosed between January 1990 2014 20 Hospitals from Spain were included. Altogether, 40.9% had granulomatosis with polyangiitis (GPA), 37.1% microscopic (MPA), 22% eosinophilic (EGPA). mean age...
IgG4-related disease (IgG4-RD) is a rare entity consisting of inflammation and fibrosis that has been described in multiple organs. Concrete diagnostic criteria have established recently there lack large series patients. To describe the clinical presentation, histopathological characteristics, treatment evolution IgG4-RD Spanish A retrospective multicenter study was performed. Twelve hospitals across Spain included patients meeting current 2012 consensus on diagnosis. Fifty-five were study,...
The progression of nonalcoholic fatty liver disease (NAFLD) to steatohepatitis (NASH) is linked systemic inflammation. Currently, two the aspects that need further investigation are diagnosis and treatment NASH. In this sense, aim study was assess relationship between circulating levels cytokines, hepatic expression toll-like receptors (TLRs), degrees NAFLD, investigate whether these could serve as noninvasive biomarkers present assessed plasma cytokines in 29 normal-weight women 82 with...
ABSTRACT We assessed the in vitro toxicity of tenofovir (TFV) and compared it with those zidovudine (AZT), didanosine (ddI), ritonavir (RTV), lopinavir (LPV) alone combination human renal proximal tubule epithelial cells (RPTECs). The were treated various concentrations combinations tested antiretrovirals for up to 22 days, cytotoxicity was determined. In addition, we levels mitochondrial DNA (mtDNA) cytochrome oxidase II (COII) mRNA RPTECs reverse transcriptase inhibitors. TFV not...
Objective To compare the accuracy of Birmingham Vasculitis Activity Score ( BVAS ), version 3, and Five Factor FFS 1996 2009, to assess survival in antineutrophil cytoplasmic antibody–associated vasculitis AAV ). Methods A total 550 patients with (41.1% granulomatosis polyangiitis, 37.3% microscopic 21.6% eosinophilic polyangiitis), diagnosed between 1990 2016, were analyzed. Receiver operating characteristic ROC ) curves multivariable Cox analysis used relationships outcome different...
To analyze the frequency and clinical phenotype of neurosarcoidosis (NS) in one largest nationwide cohorts patients with sarcoidosis reported from southern Europe. NS was evaluated according to Diagnostic Criteria for Central Nervous System Peripheral Sarcoidosis recently proposed by Stern et al. Pathologic confirmation granulomatous disease used subclassify into definite (confirmation neurological tissue), probable extraneurological tissue) possible (no histopathological disease). Of 1532...
To analyze whether immune-mediated diseases (IMDs) occurs in sarcoidosis more commonly than expected the general population, and how concomitant IMDs influence clinical presentation of disease.We searched for coexisting patients included SARCOGEAS-cohort, a multicenter nationwide database consecutive diagnosed according to ATS/ESC/WASOG criteria. Comparisons were made considering presence or absence IMD clustering, odds ratios (OR) their 95% confidence intervals (CI) calculated as ratio...
The cytokine signature present in COVID-19 could provide information on the pathogenic mechanisms of disease and identify possible prognostic biomarkers therapeutic targets. In this longitudinal work, we studied clinical biochemical parameters circulating levels 146 patients at time admission for 4-6 weeks later. main objective study was to determine whether basal cytokines be early COVID-19, also analyze impact comorbidities, such as obesity or metabolic syndrome (MS), profile. most...
What baseline predictors would be involved in mortality people with primary Sjögren syndrome (SjS) remains uncertain. This study aimed to investigate the characteristics collected at time of diagnosis SjS associated and identify risk factors for all-cause death deaths related systemic activity measured by ESSDAI score.In this international, real-world, retrospective, cohort study, we retrospectively data from 27 countries on causes Big Data Registry. Inclusion criteria consisted fulfilling...
Objectives: Poor immunological recovery in treated HIV-infected patients is associated with greater morbidity and mortality. To date, predictive biomarkers of this incomplete immune reconstitution have not been established. We aimed to identify a baseline metabolomic signature poor after antiretroviral therapy (ART) envisage the underlying mechanistic pathways that influence treatment response. Design: This was multicentre, prospective cohort study ART-naive pre-ART low nadir (<200 cells/μl)...
Coronavirus-19 (COVID-19) disease is driven by an unchecked immune response to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus which alters host mitochondrial-associated mechanisms. Compromised mitochondrial health results in abnormal reprogramming of glucose metabolism, can disrupt extracellular signalling. We hypothesized that examining energy-related signalling metabolites implicated SARS-CoV-2 infection would provide potential biomarkers for predicting risk...
Background. The incidence and mortality rate for cancer in patients with primary immunodeficiency diseases have increased greatly. Lymphomas constitute more than 50% of tumors identified the Immunodeficiency Cancer Registry, but solid are frequent these patients, especially gastric carcinomas. In addition to immunologic impairment, other local conditions such as chronic atrophic gastritis intestinal metaplasia pernicious anemia, usually observed may play an important role genesis...
Aim To study the influence of prednisone dose during first month after systemic lupus erythematosus (SLE) diagnosis (prednisone-1) on glucocorticoid burden subsequent 11 months (prednisone-2–12). Methods 223 patients from Registro Español de Lupus Eritematoso Sistémico inception cohort were studied. The cumulative prednisone-1 and prednisone-2–12 calculated recoded into a four-level categorical variable: no prednisone, low (up to 7.5 mg/day), medium 30 mg/day) high (over mg/day). association...
Abstract The immunological, biochemical and molecular mechanisms associated with poor immune recovery are far from known, metabolomic profiling offers additional value to traditional soluble markers. Here, we present novel relevant data that could contribute better understanding of the preceding a discordant response HIV progression under suppressive combined antiretroviral therapy (cART). Integrated nuclear magnetic resonance (NMR)-based lipoprotein profiles, mass spectrometry (MS)-based...
The metabolic alterations caused by SARS-CoV-2 infection reflect disease progression. To analyze molecules involved in these changes, a multiomics study was performed using plasma from 103 patients with different degrees of COVID-19 severity during the evolution infection. With increased COVID-19, changes circulating proteomic, metabolomic, and lipidomic profiles increased. Notably, group severe critical high HRG ChoE (20:3) low alpha-ketoglutaric acid levels had chance unfavorable (AUC =...
The association of systemic lupus erythematosus (SLE) and malignancy has been reported previously suggests an increased risk cancer in this disease. Lymphomas are the most frequent neoplasias these patients carcinoma cervix breast also seen. Several factors probably play a role aetiology malignancies associated with SLE including intrinsic disturbances immunity concomitant immunosuppressive therapy. We report five solid tumors (one carcinoma, one squamous cell anus, adenocarcinoma rectum,...
Abstract. Background. Few data are available on the clinical features of patients who develop breakthrough bacteraemia, understood as positive blood cultures despite appropriate antibiotic therapy. Objectives. To determine significance and outcome a large series bacteraemia. Design. Retrospective analysis prospectively collected database. Setting. Two university‐affiliated hospitals in Catalonia, Spain. Subjects. A total 392 individuals suffered an episode bacteraemia recorded between 1997...