A5018789992- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Diet and metabolism studies
- Metabolism, Diabetes, and Cancer
- HIV-related health complications and treatments
- Fungal and yeast genetics research
- Peroxisome Proliferator-Activated Receptors
- Fatty Acid Research and Health
- Metabolomics and Mass Spectrometry Studies
- Gut microbiota and health
- Cancer, Hypoxia, and Metabolism
- Diet, Metabolism, and Disease
- Endoplasmic Reticulum Stress and Disease
- Dietary Effects on Health
- Liver Disease Diagnosis and Treatment
- Pancreatic function and diabetes
- Circadian rhythm and melatonin
- Lipid metabolism and disorders
- Lipid metabolism and biosynthesis
- HIV Research and Treatment
- Cancer-related Molecular Pathways
- Cardiovascular Disease and Adiposity
- Muscle metabolism and nutrition
- Nutrition, Genetics, and Disease
- Plant Gene Expression Analysis
Technological Center of Nutrition and Health
2020-2025
Instituto de Salud Carlos III
2011-2025
Institut d'Investigació Sanitària Pere Virgili
2009-2025
Universitat Rovira i Virgili
2012-2025
Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition
2025
Universidad de Navarra
2016-2023
Wageningen University & Research
2022
Technology Centre Prague
2022
University of Pamplona
2018
Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas
2010-2017
Lipid overload in obesity and type 2 diabetes is associated with adipocyte dysfunction, inflammation, macrophage infiltration, decreased fatty acid oxidation (FAO). Here, we report that the expression of carnitine palmitoyltransferase 1A (CPT1A), rate-limiting enzyme mitochondrial FAO, higher human adipose tissue macrophages than adipocytes it differentially expressed visceral vs. subcutaneous both an obese a cohort. These observations led us to further investigate potential role CPT1A...
The increase in glucagon-like peptide-1 (GLP-1) activity has emerged as a useful therapeutic tool for the treatment of type 2 diabetes mellitus. actions GLP-1 on β-cells and nervous digestive systems are well known. action this peptide adipose tissue (AT), however, is still poorly defined. Furthermore, no relationship been established between receptor (GLP-1R) AT obesity insulin resistance (IR). We provide evidence presence show that its mRNA protein expressions increased visceral depots...
The beneficial actions of n-3 fatty acids on obesity-induced insulin resistance and inflammation have been related to the synthesis specialized proresolving lipid mediators (SPMs) like resolvins. aim this study was evaluate ability one these SPMs, maresin 1 (MaR1), reverse adipose tissue and/or in two models obesity: diet-induced obese (DIO) mice genetic (ob/ob) mice. In DIO mice, MaR1 (2 mg/kg; 10 d) reduced F4/80-positive cells expression proinflammatory M1 macrophage phenotype marker...
The gut microbiota contributes to the pathophysiology of non-alcoholic fatty liver disease (NAFLD). Histidine is a key energy source for microbiota, scavenging it from host. Its role in NAFLD poorly known. Plasma metabolomics, transcriptomics, and fecal metagenomics were performed three human cohorts coupled with hepatocyte, rodent, Drosophila models. Machine learning analyses identified plasma histidine as being strongly inversely associated steatosis linked hepatic transcriptomic signature...
Background FABP4 is predominantly expressed in adipose tissue, and its circulating levels are linked with obesity a poor atherogenic profile. Objective In patients wide BMI range, we analyze expression hepatic tissues the settings of insulin resistance. Associations between tissue plasma level as well main adipogenic lipolytic genes were also analyzed. Methods The several lipogenic, lipolytic, PPAR family FABP was analyzed by real time PCR. protein total fractions determined western blot....
Insulin resistance is a fundamental pathogenic factor that characterizes various metabolic disorders, including obesity and type 2 diabetes. Adipose tissue contributes to the development of obesity-related insulin through increased release fatty acids, altered adipokine secretion, and/or macrophage infiltration cytokine release. Here, we aimed analyze participation cyclin-dependent kinase 4 (CDK4) in adipose biology. We determined white (WAT) from CDK4-deficient mice exhibits impaired...
Context: Zinc-α2-glycoprotein (ZAG) is a soluble protein similar to the class I major histocompatibility complex heavy chain, which has been implicated in lipid catabolism. We hypothesized that ZAG mRNA expression adipose tissue may be linked with lipolytic and adipokine gene have close relationship clinical phenotype. Objectives: The objective of study was analyze human from lean obese subjects. circulating plasma levels its cardiometabolic risk factors were also studied. Design:...
Growing evidence suggests that biomarker-guided dietary interventions can optimize response to treatment. In this study, we evaluated the efficacy of PREVENTOMCIS platform-which uses metabolomic and genetic information classify individuals into different 'metabolic clusters' create personalized plans-for improving health outcomes in subjects with overweight or obesity.A 10-week parallel, double-blinded, randomized intervention was conducted 100 adults (82 completers) aged 18-65 years, body...
Maresin 1 (MaR1) is a docosahexaenoic acid-derived proresolving lipid mediator with insulin-sensitizing and anti-steatosis properties. Here, we aim to unravel MaR1 actions on brown adipose tissue (BAT) activation white (WAT) browning.
AQP7 is considered to be the sole adipose glycerol channel, and its regulation crucial for glycemia control.In this work, we aimed further characterize in human tissue obesity type 2 diabetes (T2D): 1) assess expression levels paired abdominal depots (sc visceral); 2) relate it with gene of genes involved lipid metabolism; 3) confirm that mainly expressed adipocytes.We conducted a transversal study samples sc (SAT) visceral (VAT).Caucasian lean obese subjects (n = 62, matched age gender) T2D...
Zinc-α(2) glycoprotein (ZAG) stimulates lipid loss by adipocytes and may be involved in the regulation of adipose tissue metabolism. However, to date no studies have been made most extreme obesity. The aims this study are analyze ZAG expression levels from morbidly obese patients, their relationship with lipogenic lipolytic genes insulin resistance (IR).mRNA PPARγ, IRS-1, IRS-2, were quantified visceral (VAT) subcutaneous (SAT) 25 nondiabetic 11 low IR 14 high IR. Plasma was also...
The gut is a selective barrier that not only allows the translocation of nutrients from food, but also microbe-derived metabolites to systemic circulation flows through liver. Microbiota dysbiosis occurs when energy imbalances appear due an unhealthy diet and sedentary lifestyle. Dysbiosis has critical impact on increasing intestinal permeability epithelial deterioration, contributing bacterial antigen liver, triggering non-alcoholic fatty liver disease (NAFLD) progression. In this study,...
Abstract Wastewater-based epidemiology has shown to be an efficient tool track the circulation of SARS-CoV-2 in communities assisted by wastewater treatment plants (WWTPs). The challenge comes when this approach is employed help Health authorities their decision-making. Here, we describe roadmap for design and deployment SARSAIGUA, Catalan Surveillance Network Sewage. network monitors, weekly or biweekly, 56 WWTPs evenly distributed across territory serving 6 M inhabitants (80% population)....
Polyphenol-rich extracts derived from agricultural by-products exhibit promising antiviral properties. This study evaluated the potential of red onion peels, vineyard prunings, olive prunings and chicory leaves against human coronavirus HuCoV-229E. Subcritical water extraction resin adsorption techniques were applied to produce extracts. The further characterised for their bioactive content, three out four showed a high polyphenol content (>200 mg/g). activity was assessed through viral...