A5034007055- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Circular RNAs in diseases
- Diet and metabolism studies
- RNA modifications and cancer
- MicroRNA in disease regulation
- Mitochondrial Function and Pathology
- Exercise and Physiological Responses
- Cholesterol and Lipid Metabolism
- Lipid metabolism and biosynthesis
- Endoplasmic Reticulum Stress and Disease
- Extracellular vesicles in disease
- Cardiac Valve Diseases and Treatments
- Regulation of Appetite and Obesity
- RNA Research and Splicing
- Pancreatic function and diabetes
- Peroxisome Proliferator-Activated Receptors
- Aortic Disease and Treatment Approaches
- Liver Disease Diagnosis and Treatment
- Lipid Membrane Structure and Behavior
- Muscle metabolism and nutrition
- Metabolism, Diabetes, and Cancer
- Cardiovascular Disease and Adiposity
- Cardiovascular Issues in Pregnancy
- Dietary Effects on Health
Universitat de Barcelona
2014-2024
Institut de Biomedicina de la Universitat de Barcelona
2015-2024
Biomedical Research and Innovation Institute of Cadiz
2019-2023
Universidad de Cádiz
2019-2023
Hospital Universitario Puerta del Mar
2022-2023
Biomedical Research Institute
2021
University of Lisbon
2021
University of Girona
2021
Keele University
2020
University of Minnesota Rochester
2020
Lipid overload in obesity and type 2 diabetes is associated with adipocyte dysfunction, inflammation, macrophage infiltration, decreased fatty acid oxidation (FAO). Here, we report that the expression of carnitine palmitoyltransferase 1A (CPT1A), rate-limiting enzyme mitochondrial FAO, higher human adipose tissue macrophages than adipocytes it differentially expressed visceral vs. subcutaneous both an obese a cohort. These observations led us to further investigate potential role CPT1A...
Abstract Obesity is associated with severe metabolic diseases such as type 2 diabetes, insulin resistance, cardiovascular disease and some forms of cancer. The pathophysiology obesity-induced has been strongly related to white adipose tissue (WAT) dysfunction through several mechanisms fibrosis, apoptosis, inflammation, ER oxidative stress. However, little known whether these processes are also present in brown (BAT) during obesity, the potential consequences on mitochondrial activity. Here...
The prevalence of nonalcoholic fatty liver disease (NAFLD) has increased drastically due to the global obesity pandemic but at present there are no approved therapies. Here, we aimed revert high-fat diet (HFD)-induced and NAFLD in mice by enhancing acid oxidation (FAO). Moreover, searched for potential new lipid biomarkers monitoring steatosis humans. We used adeno-associated virus (AAV) deliver a permanently active mutant form human carnitine palmitoyltransferase 1A (hCPT1AM), key enzyme...
The discovery of active brown adipose tissue (BAT) in adult humans and the fact that it is reduced obese diabetic patients have put a spotlight on this as key player obesity-induced metabolic disorders. BAT regulates energy expenditure through thermogenesis; therefore, harnessing its thermogenic fat-burning power an attractive therapeutic approach. We aimed to enhance thermogenesis by increasing fatty acid oxidation (FAO) rate. Thus, we expressed carnitine palmitoyltransferase 1AM (CPT1AM),...
Despite the extraordinary advances achieved to beat COVID-19 disease, many questions remain unsolved, including mechanisms of action SARS-CoV-2 and which factors determine why individuals respond so differently viral infection. Herein, we performed an in silico analysis identify host microRNA targeting ACE2, TMPRSS2, and/or RAB14, all genes known participate entry replication. Next, levels six candidates previously linked respiratory-related pathologies were measured serum COVID-19-negative...
Objectives The use of antioxidant therapy in the treatment oxidative stress-related diseases such as cardiovascular disease, diabetes or obesity remains controversial. Our aim is to demonstrate that supplementation may promote negative effects if used before establishment stress due a reduced ROS generation under physiological levels, mice model obesity. Methods C57BL/6J were fed with high-fat diet for 14 weeks, (OE group) without (O vitamin E supplementation. Results O developed mild degree...
Carnitine palmitoyltransferase 1C (CPT1C) is implicated in central regulation of energy homeostasis. Our aim was to investigate whether CPT1C the ventromedial nucleus hypothalamus (VMH) involved activation brown adipose tissue (BAT) thermogenesis early stages diet-induced obesity.CPT1C KO and wild type (WT) mice were exposed short-term high-fat (HF) diet feeding or intracerebroventricular leptin administration BAT evaluated. Body weight, adiposity, food intake, leptinemia also assayed.Under...
It is unknown how plasma leptin affects fat oxidation depending on sex in young adults. Therefore, the present cross-sectional study aimed to examine associations of with resting (RFO), maximal during exercise (MFO), and insulin sensitivity, considering different responses men women, mediating role fatness cardiorespiratory fitness (CRF). Sixty-five adults (22.5 ± 4.3 years; body mass index = 25.2 4.7 kg·m-2, 23 females) participated this study. Fasting glucose, insulin, were analyzed....
Abstract Dilated cardiomyopathy (DCM) is the third most common cause of heart failure. The multidisciplinary nature testing — involving genetics, imaging, or cardiovascular techniques makes its diagnosis challenging. Novel and reliable biomarkers are needed for early identification tailored personalized management. Peripheral circular RNAs (circRNAs), a leading research topic, remain mostly unexplored in DCM. We aimed to assess whether peripheral circRNAs expressed differentially among...
Abstract The left ventricular (LV) ejection fraction (EF) is key to prognosis in dilated cardiomyopathy (DCM). Circulating microRNAs have emerged as reliable biomarkers for heart diseases, included DCM. Clinicians need improved tools greater clarification of DCM EF categorization, identify high-risk patients. Thus, we investigated whether microRNA profiles can categorize patients based on their EF. 179-differentially expressed circulating were screened two groups: (1) non-idiopathic DCM; (2)...
StarD5 belongs to the StarD4 subfamily of steroidogenic acute regulatory lipid transfer (START) domain proteins. In macrophages, is found in cytosol and maintains a loose association with Golgi. Like StarD1 StarD4, known bind cholesterol. However, its function regulation remain poorly defined. Recently, it has been shown that mRNA expression induced response different inducers endoplasmic reticulum (ER) stress. molecular mechanism(s) involved induction during ER stress not known. Here we...
This study aims to analyse sex-specific associations of physical activity and sedentary behaviour with oxidative stress inflammatory markers in a young-adult population. Sixty participants (21 women, 22.63 ± 4.62 years old) wore hip accelerometer for 7 consecutive days estimate their sedentarism. Oxidative (catalase, superoxide dismutase, glutathione peroxidase, glutathione, malondialdehyde, advanced oxidation protein products) (tumour necrosis factor-alpha interleukin-6) were measured....
Bariatric surgery is effective for the treatment and remission of obesity type 2 diabetes, but pharmacological approaches which exert similar metabolic adaptations are needed to avoid post-surgical complications. Here we show how G49, an oxyntomodulin (OXM) analog dual glucagon/glucagon-like peptide-1 receptor (GCGR/GLP-1R) agonist, triggers inter-organ crosstalk between adipose tissue, pancreas, liver initiated by a rapid release free fatty acids (FFAs) white tissue (WAT) in GCGR-dependent...
The rediscovery of brown adipose tissue (BAT) in humans and its capacity to oxidize fat dissipate energy as heat has put the spotlight on potential a therapeutic target treatment several metabolic conditions including obesity diabetes. To date measurement bioenergetics parameters required use cultured cells or extracted mitochondria with corresponding loss information context. Herein, we present method quantify mitochondrial directly BAT. Based XF Seahorse Technology, assessed appropriate...