A5066089747- Liver Disease Diagnosis and Treatment
- Extracellular vesicles in disease
- Diet, Metabolism, and Disease
- Diabetes and associated disorders
- MicroRNA in disease regulation
- Helicobacter pylori-related gastroenterology studies
- Fibroblast Growth Factor Research
- Cancer, Hypoxia, and Metabolism
- Digestive system and related health
- Gut microbiota and health
- Adipose Tissue and Metabolism
- Pancreatic function and diabetes
- Alcohol Consumption and Health Effects
- Bariatric Surgery and Outcomes
- Cardiovascular Disease and Adiposity
- Probiotics and Fermented Foods
- Liver Disease and Transplantation
- Diet and metabolism studies
- Gastrointestinal motility and disorders
- Metabolism, Diabetes, and Cancer
- Pancreatitis Pathology and Treatment
- Endoplasmic Reticulum Stress and Disease
- Drug-Induced Hepatotoxicity and Protection
- Ferroptosis and cancer prognosis
- Protein Tyrosine Phosphatases
Instituto de Salud Carlos III
2020-2024
Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas
2020-2024
University of Illinois Chicago
2024
Instituto de Investigaciones Biomédicas Sols-Morreale
2020-2023
Universidad Autónoma de Madrid
2020-2023
Consejo Superior de Investigaciones Científicas
2022
Universidad Complutense de Madrid
2022
Lipotoxicity triggers non-alcoholic fatty liver disease (NAFLD) progression owing to the accumulation of toxic lipids in hepatocytes including saturated acids (SFAs), which activate pro-inflammatory pathways. We investigated impact hepatocyte- or circulating-derived small extracellular vesicles (sEV) secreted under NAFLD conditions on inflammation and hepatocyte insulin signalling. sEV released by primary mouse hepatocytes, characterised analysed lipidomics, were added macrophages/Kupffer...
Bariatric surgery is effective for the treatment and remission of obesity type 2 diabetes, but pharmacological approaches which exert similar metabolic adaptations are needed to avoid post-surgical complications. Here we show how G49, an oxyntomodulin (OXM) analog dual glucagon/glucagon-like peptide-1 receptor (GCGR/GLP-1R) agonist, triggers inter-organ crosstalk between adipose tissue, pancreas, liver initiated by a rapid release free fatty acids (FFAs) white tissue (WAT) in GCGR-dependent...
Olanzapine (OLA), a widely used second-generation antipsychotic (SGA), causes weight gain and metabolic alterations when administered orally to patients. Recently, we demonstrated that, contrarily the oral treatment which induces gain, OLA via intraperitoneal (i.p.) in male mice resulted body loss. This protection was due an increase energy expenditure (EE) through mechanism involving modulation of hypothalamic AMPK activation by higher levels reaching this brain region compared those...
Non-alcoholic steatohepatitis (NASH) is characterized by a robust pro-inflammatory component at both hepatic and systemic levels together with disease-specific gut microbiome signature. Protein tyrosine phosphatase 1 B (PTP1B) plays distinct roles in non-immune immune cells, the latter inhibiting signaling cascades. In this study, we have explored role of PTP1B composition microbiota barrier dynamics methionine choline-deficient (MCD) diet-induced NASH mice. Gut features permeability were...
Second-generation antipsychotics (SGAs), in particular, olanzapine and clozapine, have been associated with the development of type 2 diabetes mellitus (T2D) metabolic syndrome individuals schizophrenia. In this context, beta cell dysfunction is a plausible mechanism by which SGAs cause T2D. Herein, we analyzed direct effects olanzapine, commonly prescribed SGA diabetogenic properties, on INS-1 (821/13) line isolated pancreatic islets. Treatment cells non-toxic concentrations (3-6 μM) during...
Previously, we demonstrated that Spp1
The liver exhibits a variety of functions that are well-preserved during aging. However, the cellular hallmarks aging increase risk hepatic alterations and development chronic diseases. Acetaminophen (APAP) is first choice for relieving mild-to-moderate pain. Most knowledge about APAP-mediated hepatotoxicity arises from acute overdose studies due to massive oxidative stress inflammation, but little known its effect in age-related inflammation after exposure. Our results show treatment...
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic worldwide. NAFLD, hepatic manifestation metabolic syndrome, closely associates with insulin resistance, type 2 diabetes mellitus, obesity and cardiovascular disease. Until now, specific factors involved in progression NAFLD from to non-alcoholic steatohepatitis, cirrhosis and, ultimately hepatocellular carcinoma have not been totally elucidated. Also, patients face lack efficient or personalized treatments, as well...