A5049367942- Adipose Tissue and Metabolism
- Regulation of Appetite and Obesity
- Diet and metabolism studies
- Pancreatic function and diabetes
- Cannabis and Cannabinoid Research
- Sleep and Wakefulness Research
- Biochemical Analysis and Sensing Techniques
- Metabolomics and Mass Spectrometry Studies
- Dietary Effects on Health
- Neuroscience and Neuropharmacology Research
- Diet, Metabolism, and Disease
- Metabolism and Genetic Disorders
- Alcohol Consumption and Health Effects
Universitat Internacional de Catalunya
2018-2024
SF1 neurons of the ventromedial hypothalamus (VMH) play a pivotal role in regulating body weight and adiposity, particularly response to high-fat diet (HFD), as well recovery from insulin-induced hypoglycemia. While brain-specific CPT1C isoform is known for its controlling food intake energy homeostasis, function within specific hypothalamic neuronal populations remains largely unexplored. Here, we demonstrate that essential appropriate responses dietary fats. Mice deficient fail adjust...
Sensing of long-chain fatty acids (LCFA) in the hypothalamus modulates energy balance, and its disruption leads to obesity. To date, effects saturated or unsaturated LCFA on hypothalamic-brown adipose tissue (BAT) axis underlying mechanisms have remained largely unclear. Our aim was characterize main molecular pathways involved hypothalamic regulation BAT thermogenesis response with different lengths degrees saturation. One-week administration high-fat diet enriched monounsaturated FA led...
Carnitine palmitoyltransferase 1C (CPT1C) is implicated in central regulation of energy homeostasis. Our aim was to investigate whether CPT1C the ventromedial nucleus hypothalamus (VMH) involved activation brown adipose tissue (BAT) thermogenesis early stages diet-induced obesity.CPT1C KO and wild type (WT) mice were exposed short-term high-fat (HF) diet feeding or intracerebroventricular leptin administration BAT evaluated. Body weight, adiposity, food intake, leptinemia also assayed.Under...
The endocannabinoid (eCB) system regulates energy homeostasis and is linked to obesity development. However, the exact dynamic regulation of eCBs in hypothalamus during progression remain incompletely described understood. Our study examined time course responses two hypothalamic eCBs, 2-arachidonoylglycerol (2-AG) arachidonoylethanolamine (AEA), male female mice diet-induced explored association eCB levels with changes brown adipose tissue (BAT) thermogenesis body weight. We fed a high-fat...
The enzyme α/β-hydrolase domain containing 6 (ABHD6), a new member of the endocannabinoid system, is promising therapeutic target against neuronal-related diseases. However, how ABHD6 activity regulated not known. coexists in protein complexes with brain-specific carnitine palmitoyltransferase 1C (CPT1C). CPT1C involved neuro-metabolic functions, depending on brain malonyl-CoA levels. Our aim was to study CPT1C-ABHD6 interaction and determine whether key regulator nutritional...
ABSTRACT The SF1 neurons of the ventromedial hypothalamus (VMH) are pivotal in governing body weight and adiposity, particularly response to a high-fat diet (HFD). Previous studies have shown that activation induces satiety, increases energy expenditure, promotes preferential use fats as substrate. Furthermore, necessary for recovering from insulin-induced hypoglycemia. Here we demonstrate essential role nutritional sensor CPT1c by dietary fats. Mice deficient CPT1C (SF1- -KO) unable adjust...
Targeting brain lipid metabolism using polymeric-based nanomedicine is a promising strategy to regulate the energy balance and fight metabolic diseases such as obesity.