A5047000779- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Peroxisome Proliferator-Activated Receptors
- Gestational Diabetes Research and Management
- Birth, Development, and Health
- Proteoglycans and glycosaminoglycans research
- Calpain Protease Function and Regulation
- Regulation of Appetite and Obesity
- Fatty Acid Research and Health
- Kruppel-like factors research
- Biochemical Analysis and Sensing Techniques
- Neuroinflammation and Neurodegeneration Mechanisms
- Liver Disease Diagnosis and Treatment
- Apelin-related biomedical research
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Protein Tyrosine Phosphatases
- Exercise and Physiological Responses
- Lipid metabolism and biosynthesis
- Infrared Thermography in Medicine
- Alcohol Consumption and Health Effects
- Pancreatic function and diabetes
- Diet and metabolism studies
- Cardiovascular Disease and Adiposity
- Chromatography in Natural Products
- Bone Metabolism and Diseases
Universidad San Pablo CEU
2010-2024
Lawson Health Research Institute
2022
Universidad San Pablo
2020
Insulin resistance plays a role in the pathogenesis of diabetes, including gestational diabetes. The glucose clamp is considered gold standard for determining vivo insulin sensitivity, both human and animal models. However, laborious, time consuming and, animals, requires anesthesia collection multiple blood samples. In studies, number simple indexes, derived from fasting levels, have been obtained validated against clamp. these indexes not rats their accuracy predicting altered sensitivity...
Objective To test whether enhancing the capability of adipose tissue to store lipids using antioxidant supplementation may prevent lipotoxic effects and improve metabolic profile long‐term obesity. Methods C57BL/6J mice were randomized into three experimental groups for 28 weeks: control group ( n = 10) fed chow diet (10% kcal from fat), obese (O, 12) high‐fat (HF) (45% HF supplemented twice a week with 150 mg α‐tocopherol (vitamin E) by oral gavage (OE, 12). Results resulted in an phenotype...
Insulin resistance is a characteristic of late pregnancy, and adipose tissue one the tissues that most actively contributes to reduced maternal insulin sensitivity. There evidence pregnancy condition moderate inflammation, although physiological role this low-grade inflammation remains unclear. The present study was designed validate whether plays in development during pregnancy. To end, we analyzed proinflammatory adipokines kinases lumbar nonpregnant pregnant rats at d 18 20 gestation. We...
Insulin resistance is a hallmark of late pregnancy both in human and rat. Adipose tissue one the tissues that most actively contributes to this reduced insulin sensitivity. The aim present study was characterize molecular mechanisms adipose at pregnancy. To end, we analyzed signaling cascade lumbar nonpregnant pregnant (d 20) rats under basal insulin-stimulated conditions. We found levels relevant proteins, such as receptor (IR), IR substrate-1 (IRS-1), phosphatidylinositol 3-kinase,...
Pregnancy requires the adaptation of maternal energy metabolism including expansion and functional modifications adipose tissue. Insulin resistance (IR), predominantly during late gestation, is a physiological metabolic that serves to support demands fetal growth. The molecular mechanisms underlying these adaptations are not fully understood may contribute gestational diabetes mellitus. Peroxisome proliferator-activated receptor gamma (PPARγ) controls adipogenesis, glucose lipid insulin...
Binge drinking during adolescence increases the risk of alcohol use disorder, possibly by involving alterations neuroimmune responses. Pleiotrophin (PTN) is a cytokine that inhibits Receptor Protein Tyrosine Phosphatase (RPTP) β/ζ. PTN and MY10, an RPTPβ/ζ pharmacological inhibitor, modulate ethanol behavioral microglial responses in adult mice. Now, to study contribution endogenous implication its receptor neuroinflammatory response prefrontal cortex (PFC) after acute exposure adolescence,...
Scope: fructose consumption from added sugars correlates with the epidemic rise in MetS and CVD. Maternal intake has been described to program metabolic diseases progeny. However, of fructose-containing beverages is allowed during gestation. Cholesterol also a well-known risk factor for Therefore, it essential study Western diets which combine cholesterol how maternal can influence response progeny these diets. Methods results: high-cholesterol (2%) diet combined liquid (10%), as model an...
The level of maternal circulating triacylglycerols during late pregnancy has been correlated with the mass newborns. PPARγ (peroxisome-proliferator-activated receptor γ) ligands, such as TZDs (thiazolidinediones), have shown to reduce triacylglycerolaemia and also implicated in inhibition tissue growth promotion cell differentiation. Therefore might control proliferation fetal development and, by extension, body pups. To investigate response EZ (englitazone), a TZD, on perinatal development,...
Pleiotrophin (PTN) is a heparin-binding cytokine that widely expressed during early development and increases in maternal circulation pregnancy.Aged PTN-deficient mice exhibit insulin resistance, suggesting role metabolic control. The objectives of this study were to determine if PTN mouse pancreatic β-cells young vs. adult animals, its effects on DNA synthesis, β-cell gene expression glucose-stimulated secretion (GSIS). Ptn was isolated fractions β-cells, especially within immature with low...
(1) Background: Pleiotrophin preserves insulin sensitivity, regulates adipose tissue lipid turnover and plasticity, energy metabolism thermogenesis. The aim of this study was to determine the role pleiotrophin in hepatic metabolic crosstalk between liver brown white (AT) a high-fat diet-induced (HFD) obesity mice model. (2) Methods: We analyzed circulating variables, (hepatic content mRNA expression), AT thermogenesis (UCP-1 expression) periovarian browning (brown adipocyte markers...
Pleiotrophin is a pleiotropic cytokine that has been demonstrated to have critical role in regulating energy metabolism, lipid turnover and plasticity of adipose tissue. Here, we hypothesize this can be involved regulatory processes glucose homeostasis the liver during pregnancy. Using 18-days pregnant Ptn-deficient mice, evaluated biochemical profile (circulating variables), tissue mRNA expression (qPCR) protein levels key enzymes transcription factors main metabolic pathways. Ptn deletion...
Pleiotrophin (PTN) is crucial for embryonic development and pancreas organogenesis as it regulates metainflammation, metabolic homeostasis, thermogenesis, glucose tolerance. deletion associated with a lipodystrophic phenotype in which adipose tissue plasticity altered late life. This study explored the impact of pleiotrophin on pancreatic morphology function later We analyzed tolerance circulating parameters female wild-type (Ptn+/+) knock-out (Ptn−/−) mice. At 9 15 months, we conducted...