A5077934558- Fungal and yeast genetics research
- Bone health and treatments
- Prostate Cancer Treatment and Research
- Gene Regulatory Network Analysis
- RNA Research and Splicing
- Genomics and Chromatin Dynamics
- Endoplasmic Reticulum Stress and Disease
- Bone Metabolism and Diseases
- DNA Repair Mechanisms
- CRISPR and Genetic Engineering
- Plant-Microbe Interactions and Immunity
- Single-cell and spatial transcriptomics
- Ubiquitin and proteasome pathways
- RNA and protein synthesis mechanisms
- Cancer-related Molecular Pathways
- Viral Infectious Diseases and Gene Expression in Insects
- Protein Degradation and Inhibitors
- Genetics, Bioinformatics, and Biomedical Research
- Management of metastatic bone disease
- Plant Gene Expression Analysis
- Heat shock proteins research
- Neuroblastoma Research and Treatments
- RNA modifications and cancer
- Melanoma and MAPK Pathways
- Fungal Biology and Applications
Universitat Pompeu Fabra
2016-2025
Institute for Research in Biomedicine
2018-2025
Barcelona Institute for Science and Technology
2022
Institut Català d'Oncologia
2019
Institut Català d'Ornitologia
2019
Toxicologie, Pharmacologie et Signalisation Cellulaire
2016
Barcelona Biomedical Research Park
2007-2015
Universitat Autònoma de Barcelona
1996-2001
Instituto de Biología Molecular y Celular de Plantas
1998
Consejo Superior de Investigaciones Científicas
1998
Adaptation to changes in extracellular salinity is a critical event for cell survival. Genome-wide DNA chip analysis has been used analyze the transcriptional response of yeast cells saline stress. About 7% genes encoded genome are induced more than 5-fold after mild and brief shock (0.4m NaCl, 10 min). Interestingly, most responsive showed very transient expression pattern, as mRNA levels dramatically declined 20 min presence A quite similar set increased subjected higher concentrations...
Mitogen-activated protein kinase (MAPK) cascades are conserved signaling modules that control many cellular processes by integrating intra- and extracellular cues. The p38/Hog1 MAPK is transiently activated in response to osmotic stress, leading rapid translocation into the nucleus induction of a specific transcriptional program. When investigating dynamic interplay between Hog1 activation Hog1-driven gene expression, we found increases linearly with stimulus, whereas output bimodal....
Abstract Bone metastasis from prostate cancer can occur years after prostatectomy, due to reactivation of dormant disseminated tumor cells (DTC) in the bone, yet mechanism by which DTCs are initially induced into a state bone remains be elucidated. We show here that microenvironment confers dormancy C4-2B4 cells, as they become when injected mouse femurs but not under skin. Live-cell imaging at single-cell level revealed conditioned medium differentiated, undifferentiated, osteoblasts...
Phosphorylation and fungal evolution after transcription modifies the activity of proteins. To understand how phosphorylation sites have evolved, Studer et al. studied a range species (see Perspective by Matalon ). Only few were apparently present in common ancestor all 18 investigated. Evolutionary age appeared to predict potential functional importance specific conserved phosphosites. Science , this issue p. 229 ; see also 176
Exposure ofSaccharomyces cerevisiae to increases in extracellular osmolarity activates the stress-activated Hog1 mitogen-activated protein kinase (MAPK), which is essential for cell survival upon osmotic stress.Yeast cells respond stress by inducing expression of a very large number genes, and MAPK plays critical role gene transcription stress.To understand how controls expression, we designed genetic screen isolate new factors under control identified MEF2-like factor, Smp1, as target...
Engineered synthetic biological devices have been designed to perform a variety of functions from sensing molecules and bioremediation energy production biomedicine. Notwithstanding, major limitation in vivo circuit implementation is the constraint associated use standard methodologies for design. Thus, future success these depends on obtaining circuits with scalable complexity reusable parts. Here we show how build complex computational using multicellular consortia space as key elements....
Components of cellular stress responses can be identified by correlating changes in tolerance with gain or loss function defined genes. Previous work has shown that yeast cells deficient Ppz1 protein phosphatase overexpressing Hal3p, a novel regulatory unknown function, exhibit increased resistance to sodium and lithium, whereas lacking Hal3p display sensitivity. These effects are largely result expression ENA1, encoding the major cation extrusion pump cells. Disruption overexpression HAL3...
Regulation of gene expression by the Hog1 stress-activated protein kinase is essential for proper cell adaptation to osmostress. coordinates an extensive transcriptional program through modulation transcription. To identify systematically novel components machinery required osmostress-mediated expression, we performed exhaustive genome-wide genetic screening, searching mutations that render cells osmosensitive at high osmolarity and are associated with reduced osmoresponsive genes. The SAGA...