A5053488036- Diet and metabolism studies
- Bariatric Surgery and Outcomes
- Liver Disease Diagnosis and Treatment
- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Adipose Tissue and Metabolism
- Diet, Metabolism, and Disease
- Clinical Nutrition and Gastroenterology
- Pancreatic function and diabetes
- Metabolism and Genetic Disorders
- Diabetes Management and Research
- Regulation of Appetite and Obesity
- Body Contouring and Surgery
- Drug Transport and Resistance Mechanisms
- Obesity and Health Practices
- Nutrition and Health in Aging
- Pharmacology and Obesity Treatment
- Diabetes and associated disorders
- Inflammatory Bowel Disease
- Cardiovascular Disease and Adiposity
- Adipokines, Inflammation, and Metabolic Diseases
- Muscle metabolism and nutrition
- Microscopic Colitis
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Pancreatitis Pathology and Treatment
Università Cattolica del Sacro Cuore
2016-2025
Agostino Gemelli University Polyclinic
2008-2025
King's College London
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2019-2024
University of the Sacred Heart
2014-2024
Istituto di Analisi dei Sistemi ed Informatica Antonio Ruberti
1991-2024
University of Milan
2019-2023
King's College Hospital
2017-2023
King's College School
2021-2023
University of New Orleans
2023
The American Diabetes Association and the European for Study of convened a panel to update prior position statements, published in 2012 2015, on management type 2 diabetes adults. A systematic evaluation literature since 2014 informed new recommendations. These include additional focus lifestyle self-management education support. For those with obesity, efforts targeting weight loss, including lifestyle, medication, surgical interventions, are recommended. With regards medication management,...
Roux-en-Y gastric bypass and biliopancreatic diversion can markedly ameliorate diabetes in morbidly obese patients, often resulting disease remission. Prospective, randomized trials comparing these procedures with medical therapy for the treatment of are needed.In this single-center, nonblinded, randomized, controlled trial, 60 patients between ages 30 years a body-mass index (BMI, weight kilograms divided by square height meters) 35 or more, history at least 5 diabetes, glycated hemoglobin...
The American Diabetes Association and the European for Study of have briefly updated their 2018 recommendations on management hyperglycemia, based important research findings from large cardiovascular outcomes trials published in 2019. Important changes include: 1) decision to treat high-risk individuals with a glucagon-like peptide 1 (GLP-1) receptor agonist or sodium–glucose cotransporter 2 (SGLT2) inhibitor reduce major adverse events (MACE), hospitalization heart failure (hHF), death,...
Most patients who undergo Roux-en-Y gastric bypass (RYGB) experience rapid resolution of type 2 diabetes. Prior studies indicate that this results from more than restriction and weight loss, implicating the rearranged intestine as a primary mediator. It is unclear, however, if diabetes improves because enhanced delivery nutrients to distal increased secretion hindgut signals improve glucose homeostasis, or altered excluded segment proximal intestine. We sought distinguish between these two...
Insulin resistance and insulin hypersecretion are established features of obesity. Their prevalence, however, has only been inferred from plasma concentrations. We measured sensitivity (as the whole-body insulin-mediated glucose uptake) fasting posthepatic delivery rate (IDR) with use euglycemic clamp technique in a large group obese subjects database European Group for Study Resistance (1,146 nondiabetic, normotensive Caucasian men women aged 18-85 yr, body mass index (BMI) ranging 15 to 55...
BACKGROUND Despite growing evidence that bariatric/metabolic surgery powerfully improves type 2 diabetes (T2D), existing treatment algorithms do not include surgical options. AIM The 2nd Diabetes Surgery Summit (DSS-II), an international consensus conference, was convened in collaboration with leading organizations to develop global guidelines inform clinicians and policymakers about benefits limitations of metabolic for T2D. METHODS A multidisciplinary group 48 clinicians/scholars (75%...
Diabetes and Covid-19 is associated with an increased risk of severe Covid-19. New-onset diabetes metabolic complications preexisting diabetes, including diabetic ketoacidosis h...
Obesity is a frequent cause of insulin resistance and poses major risk for diabetes. Abnormal fat deposition within skeletal muscle has been identified as mechanism obesity-associated resistance. We tested the hypothesis that dietary lipid deprivation may selectively deplete intramyocellular lipids, thereby reversing Whole-body sensitivity (by clamp technique), lipids quantitative histochemistry on quadriceps biopsies), action (as expression Glut4 glucose transporters), postprandial lipemia...
Abstract Background/Aims: High‐fat dietary intake and low physical activity lead to insulin resistance, nonalcoholic fatty liver disease (NAFLD) steatohepatitis (NASH). Recent studies have shown an effect of glucagon‐like peptide‐1 (GLP‐1) on hepatic glucose metabolism, although GLP‐1 receptors (GLP‐1r) not been found in human livers. The aim this study was investigate the presence GLP‐1r exenatide, a analogue, signalling. Methods: expression evaluated biopsies livers high‐fat diet‐treated...
The primary gene mutated in Charcot-Marie-Tooth type 2A is mitofusin-2 (Mfn2). Mfn2 encodes a mitochondrial protein that participates the maintenance of network and regulates metabolism intracellular signaling. potential for regulation human expression vivo largely unknown. Based on presence dysfunction insulin-resistant conditions, we have examined whether dysregulated skeletal muscle from obese or nonobese 2 diabetic subjects, regulated by body weight loss, regulatory role tumor necrosis...
Currently, there are no data in the literature regarding pathophysiological mechanisms involved rapid resolution of type 2 diabetes after bariatric surgery, which was reported as an additional benefit surgical treatment for morbid obesity. With this question mind, insulin sensitivity, using euglycemic-hyperinsulinemic clamp, and secretion, by C-peptide deconvolution method oral glucose load, together with circulating levels intestinal incretins adipocytokines, have been studied 10 diabetic...
Mingrone, Geltrude; Panunzi, Simona; De Gaetano, Andrea; Guidone, Caterina; Iaconelli, Amerigo; Leccesi, Laura; Nanni, Giuseppe; Pomp, Alfons; Castagneto, Marco; Ghirlanda, Giovanni; Rubino, Francesco Author Information
Since the 2007 Diabetes Surgery Summit in Rome, Italy, and subsequent publishing of world’s first guidelines for surgical treatment type 2 diabetes (T2D), much new evidence regarding efficacy safety metabolic surgery has emerged. Additional observational cohort studies support superior effects over medical with respect to glycemic control, weight loss, even reduction mortality microvascular complications associated T2D. Furthermore, data suggest that perioperative morbidity (5% 0.3%,...