A5055735434- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Monoclonal and Polyclonal Antibodies Research
- COVID-19 Clinical Research Studies
- Chronic Lymphocytic Leukemia Research
- Long-Term Effects of COVID-19
- Systemic Sclerosis and Related Diseases
- Spondyloarthritis Studies and Treatments
- Autoimmune and Inflammatory Disorders Research
- Biosimilars and Bioanalytical Methods
- Liver Diseases and Immunity
- T-cell and B-cell Immunology
- Immunodeficiency and Autoimmune Disorders
- Lymphoma Diagnosis and Treatment
- Cytokine Signaling Pathways and Interactions
- Renal Diseases and Glomerulopathies
- Ovarian function and disorders
- Inflammatory Bowel Disease
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- SARS-CoV-2 and COVID-19 Research
- Extracellular vesicles in disease
- Vasculitis and related conditions
- Reproductive System and Pregnancy
- Intensive Care Unit Cognitive Disorders
Agostino Gemelli University Polyclinic
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2018-2025
Università Cattolica del Sacro Cuore
2014-2023
Corvid Technologies (United States)
2023
Center for Rheumatology
2018
University of the Sacred Heart
2015-2017
Institute of Rheumatology
2016-2017
Società Italiana di Reumatologia
2014
Catholic University of America
2011
Abstract MicroRNA-155 (miR-155) is an important regulator of B cells in mice. have a critical role the pathogenesis rheumatoid arthritis (RA). Here we show that miR-155 highly expressed peripheral blood from RA patients compared with healthy individuals, particularly IgD - CD27 memory B-cell population ACPA + RA. MiR-155 synovial tissue containing ectopic germinal centres diffuse tissue. expression associated reciprocally lower PU.1 at level compartment. Stimulation donor CD40L, anti-IgM,...
Abstract Background Interstitial lung disease (ILD) is the most severe extra‐articular manifestation of rheumatoid arthritis (RA). Although it responsible 10–20% all RA mortality, no controlled studies are available for treatment RA‐ILD and its therapeutic approach still debated. Aims To analyse evolution ILD in a population patients treated with tocilizumab (TCZ). Methods In this national multicentre study, we retrospectively collected at least one dose TCZ. For each patient, activity...
Psoriatic arthritis (PsA) is a chronic inflammatory associated with psoriasis. A third of psoriatic patients develop PsA via unknown mechanisms. No reliable diagnostic markers are available for PsA, or prognostic biomarkers development in We previously uncovered pro-inflammatory role cathelicidin LL37 lesional psoriasis skin. binds nucleic acids and stimulates plasmacytoid/myeloid dendritic cells (pDC, mDCs) to secrete type I interferon (IFN-I) factors. becomes an autoantigen Th1-Th17/CD8 T...
Interleukin-6 signal blockade showed preliminary beneficial effects in treating inflammatory response against SARS-CoV-2 leading to severe respiratory distress. Herein we describe the outcomes of off-label intravenous use Sarilumab SARS-CoV-2-related pneumonia.53 patients with pneumonia received Sarilumab; pulmonary function improvement or Intensive Care Unit (ICU) admission rate medical wards, live discharge ICU treated and safety profile were recorded. 400 mg was administered intravenously...
We explored the potential link between chronic inflammatory arthritis and COVID-19 pathogenic resolving macrophage pathways their role in pathogenesis. found that bronchoalveolar lavage fluid (BALF) clusters FCN1+ FCN1+SPP1+ predominant severe were transcriptionally related to synovial tissue (STM) CD48hiS100A12+ CD48+SPP1+ drive rheumatoid (RA) synovitis. BALF cluster FABP4+ healthy lung was STM TREM2+ governs resolution of synovitis RA remission. Plasma concentrations SPP1 S100A12 (key...
Current treatments for rheumatoid arthritis (RA) do not reverse underlying aberrant immune function. A genetic predisposition to RA, such as HLA-DR4 positivity, indicates that dendritic cells (DC) are of crucial importance pathogenesis by activating auto-reactive lymphocytes. Here we show microRNA-34a provides homoeostatic control CD1c+ DC activation via regulation tyrosine kinase receptor AXL, an important inhibitory auto-regulator. This pathway is in DCs from patients with upregulation...
In this paper we present a comparison between standard computer vision techniques and DeepLearning approach for automatic metal corrosion (rust) detection.For the classic approach, classification based on number of pixels containing specific red components has been utilized.The code written in Python used OpenCV libraries to compute categorize images.For Deep Learning chose Caffe, powerful framework developed at "Berkeley Vision Center" (BVLC).The test performed by classifying images...
To define the synovial characteristics of patients with rheumatoid arthritis (RA) and psoriatic (PsA) in clinical ultrasound remission achieved by combination therapy methotrexate (MTX) tumour necrosis factor (TNF) blockers.Patients RA (n=25) (disease activity score (DAS)<1.6 for at least 6 months), low disease (LDA) (n=10) (1.6<DAS<2.4 months) PsA (n=18) (DAS<1.6 Psoriasis Area Severity Index (PASI)=0 MTX+anti-TNF (adalimumab 40 mg or etanercept 50 mg) power Doppler (PDUS)-negative...
Objective This study applied a synovitis score obtained during routine care from ultrasound (US)–guided biopsies of synovial tissue (ST) in patients with rheumatoid arthritis (RA) and other inflammatory noninflammatory joint diseases to identify pretreatment biomarkers associated disease characteristics, integrate the findings into multiparameter nomogram for use baseline prediction diagnosis treatment response treatment‐naive patients. Methods The enrolled total 1,015 various autoimmune...
Primary Sjögren’s disease is primarily driven by B-cell activation and associated with a high risk of developing non-Hodgkin’s lymphoma (NHL). Over the last few decades, microRNA-155 (miR-155) has arisen as key regulator B-cells. Nevertheless, its role in primary remains elusive. Thus, purpose this study was (i) to explore miR-155, activating factor (BAFF)-receptor (BAFF-R), Interleukin 6 receptor (IL-6R) expression labial salivary glands (LSG) patients disease, aiming identify potential...
Tenosynovial inflammation is a hallmark of rheumatoid arthritis (RA), even in the preclinical phase. However, tenosynovium retrieval and characterisation beyond current state-of-the-art. We aimed to (1) assess rate magnetic resonance imaging (MRI)-detected tenosynovitis wrists patients with clinical RA; (2) develop technique for retrieval; (3) characterise its cellular composition across disease phases, including comparison adjacent synovium. In total, 834 MRI wrist scans were analysed...
<title>Abstract</title> Background Rheumatoid arthritis (RA) is a heterogeneous disease. Patients vary in symptoms, prognosis and treatment response, demonstrating the need for more refined taxonomy. Objective To identify distinct phenotypic subsets of RA patients based on baseline clinical data, order to advance understanding disease etiology strategies. Methods We collected hematological, serological, data from RA-patients Leiden Rheumatology clinic(n = 1,387), combined multimodal deep...
IntroductionAs an emerging infectious disease, the clinical and virologic course of COVID-19 requires better investigation. The aim this study is to identify potential risk factors associated with persistent positive nasopharyngeal swab real-time reverse transcription‒polymerase chain reaction tests in a large sample patients who recovered from COVID-19.MethodsAfter acute phase SARS-CoV-2 epidemic infection, Fondazione Policlinico A. Gemelli IRCSS Rome established post-acute care service for...
The novel coronavirus SARS-Cov-2 can infect the respiratory tract causing a spectrum of disease varying from mild to fatal pneumonia, and known as COVID-19. Ongoing clinical research is assessing potential for long-term sequelae in these patients. We assessed function cohort patients after recovering infection, stratified according PaO2/FiO2 (p/F) values.Approximately one month hospital discharge, 86 COVID-19 underwent physical examination, arterial blood gas (ABG) analysis, pulmonary tests...
Serum albumin (ALB), one of the most important proteins in human physiology, has main functions maintaining plasma oncotic pressure and volume, transporting hormones, vitamins, oligominerals drugs, exerting a powerful antioxidant-antiinflammatory role. Its prognostic value liver malabsorption syndromes is well known.
 In this narrative review, an analysis studies evaluating significance low serum ALB levels hospitalized patients was performed. Specifically, risk emergency medicine,...
Abstract Overweight/obesity influence disease burden and clinical outcome of Rheumatoid Arthritis (RA). The impact overweight/obesity on synovial tissue (ST) inflammation is largely unknown. Here, we investigated the histological transcriptional signature ST obtained from RA in different phases (disease onset, failure to first-line conventional DMARDs sustained ultrasound remission) finding that overweight/obese naive showed higher likelihood follicular synovitis, IHC scores for sublining...