A5072579954- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Osteoarthritis Treatment and Mechanisms
- Cardiovascular Function and Risk Factors
- Medical and Biological Sciences
- Cardiovascular Disease and Adiposity
- Rheumatoid Arthritis Research and Therapies
- Peripheral Artery Disease Management
- COVID-19 Clinical Research Studies
- Inflammatory mediators and NSAID effects
- Venous Thromboembolism Diagnosis and Management
- Musculoskeletal Disorders and Rehabilitation
- Musculoskeletal synovial abnormalities and treatments
- Estrogen and related hormone effects
- Chronic Obstructive Pulmonary Disease (COPD) Research
- SARS-CoV-2 and COVID-19 Research
- Heart Rate Variability and Autonomic Control
- Diet, Metabolism, and Disease
- Asthma and respiratory diseases
- Ultrasound and Hyperthermia Applications
- Liver Disease Diagnosis and Treatment
- Lower Extremity Biomechanics and Pathologies
- Cardiac, Anesthesia and Surgical Outcomes
- Infant Health and Development
Leiden University Medical Center
2023-2025
Sint Franciscus Gasthuis
2017-2024
Maasstad Ziekenhuis
2014-2022
Erasmus MC
2008-2014
Erasmus University Rotterdam
2008-2012
In patients with ST-segment elevation myocardial infarction (STEMI), the use of percutaneous coronary intervention (PCI) to restore blood flow in an infarct-related artery improves outcomes. The PCI non-infarct-related arteries remains controversial.We randomly assigned 885 STEMI and multivessel disease who had undergone primary a 1:2 ratio undergo complete revascularization guided by fractional reserve (FFR) (295 patients) or no (590 patients). FFR procedure was performed both groups, but...
Introduction Illnesses requiring hospitalization are known to negatively impact psychological well-being and health-related quality of life (HRQoL) after discharge. The during the Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) pandemic on is expected be higher due exceptional circumstances within outside hospital surge. objective this study was quantify distress up three months discharge in patients hospitalized first coronavirus disease 2019 (COVID-19) wave. We also aimed...
To determine the symptom-modifying effect of hydroxychloroquine (HCQ) in hand osteoarthritis (OA).In this randomized, double-blind, multicenter trial, patients with symptomatic OA received either HCQ 400 mg once a day or placebo during 24 weeks. The primary outcome was change pain measured on 100-mm visual analog scale (VAS) at Secondary outcomes included decrease weeks 6 and 12 Australian Canadian Hand Osteoarthritis Index (AUSCAN) Arthritis Impact Measurement Scale 2 short form (AIMS2-SF)...
<title>Abstract</title> Background Rheumatoid arthritis (RA) is a heterogeneous disease. Patients vary in symptoms, prognosis and treatment response, demonstrating the need for more refined taxonomy. Objective To identify distinct phenotypic subsets of RA patients based on baseline clinical data, order to advance understanding disease etiology strategies. Methods We collected hematological, serological, data from RA-patients Leiden Rheumatology clinic(n = 1,387), combined multimodal deep...
Discordance between having pain and radiologic osteoarthritis (OA) is a well-established fact. It suggested that this particularly applies to the less severe grades of OA. However, some people with Kellgren/Lawrence (K/L) grade 3 or 4 for OA are without pain. This study aimed identify factors differences in associated persons different knee OA.We stratified knees more than 5,000 participants population-based cohort study, Rotterdam Study, based on Multivariate generalized estimating equation...
Aims: The Compare-Acute trial showed superiority of fractional flow reserve (FFR)-guided acute complete revascularisation compared to culprit-only treatment in patients with ST-segment elevation myocardial infarction (STEMI) and multivessel disease (MVD) at one year. aim this study was investigate the outcome three years, together cost analysis strategy. Methods results: After primary percutaneous coronary intervention (PCI), 885 STEMI MVD were randomised (1:2 ratio) FFR-guided (295...
Obesity doubles the lifetime risk of developing heart failure. Current knowledge on role obesity in causing cardiac dysfunction is insufficient for optimal stratification. The aim this study was first to estimate prevalence subclinical patients and second investigate underlying pathophysiology.The CARDIOBESE a cross-sectional multicentre 100 [body mass index (BMI) ≥ 35 kg/m2 ] without known cardiovascular disease 50 age-matched gender-matched non-obese controls (BMI ≤ 30 ). Echocardiography...
Background: Adults with a high body mass index (BMI) have an increased risk of developing asthma. To explore the impact lipids on presence asthma, this study investigated relationship between lipid levels and inflammatory markers in patients asthma controls obesity. Objective: We hypothesized that higher are more prevalent obesity Methods: In explorative cohort study, 96 45 were included. All participated one three studies; two these studies included only An diagnosis was defined by typical...
Asthma exacerbations are frequently induced by respiratory tract infections (RTIs). Bacterial lysates have been described to possess immune-modulatory effects and reduce RTIs as well asthma symptoms in children. However, whether bacterial similar adult patients is unknown.To add-on lysate therapy adults with severe characterize the clinical of this treatment.Asthma (GINA 4) ≥2 annual previous year were included. The intervention regimen consisted OM-85/placebo for 10 consecutive days per...
Adult-onset asthma (AOA) is usually more severe compared to childhood onset (CoA). Given the increasing evidence that AoA associated with obesity, we investigated relationship of other related metabolic comorbid conditions CoA.This cross-sectional study syndrome and lipid derived inflammatory markers in patients AoA, CoA age- sex-matched control subjects without asthma. Participants were visiting outpatient clinic two teaching hospitals Rotterdam, The Netherlands. All participants underwent...
Introduction In view of the increasing occurrence both obesity and heart failure, a growing overlap these two clinical entities in near future is expected. Significant advances our understanding pathophysiological consequences for cardiovascular system have been made over past decades. However, to optimise management treatment patients, further research required improve early identification cardiac dysfunction gain insight underlying pathophysiology. The CARdiac Dysfunction OBesity – Early...
Objectives It is currently impossible to identify which patients with knee complaints presenting the general practitioner will develop osteoarthritis (OA) pathology at a later stage. This study examines determinants for developing OA on x-ray in but no radiological baseline painful knee. Methods Data from prospective Rotterdam cohort (including subjects aged ≥55 years) were used. Analysis was performed 623 and their data 6-year follow-up (T1; n=607) 11-year (T2; n=457). At baseline, none had...
BackgroundIndividuals vaccinated against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), when infected, can still develop disease that requires hospitalization. It remains unclear whether these patients differ from hospitalized unvaccinated with regard to presentation, coexisting comorbidities, and outcomes.MethodsHere, we use data an international consortium study this question assess differences between groups are context specific. Data 83,163 COVID-19 (34,843 vaccinated,...