A5045853500- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Organ Transplantation Techniques and Outcomes
- Drug-Induced Hepatotoxicity and Protection
- Long-Term Effects of COVID-19
- COVID-19 and healthcare impacts
- Intensive Care Unit Cognitive Disorders
- Pancreatitis Pathology and Treatment
- Respiratory Support and Mechanisms
- Renal function and acid-base balance
- Effects of Environmental Stressors on Livestock
- Pancreatic and Hepatic Oncology Research
- Clinical Nutrition and Gastroenterology
- Appendicitis Diagnosis and Management
- Sepsis Diagnosis and Treatment
- Cardiac Arrest and Resuscitation
- Transplantation: Methods and Outcomes
- Electrolyte and hormonal disorders
- Acute Kidney Injury Research
- Meat and Animal Product Quality
- Animal Behavior and Welfare Studies
- Agriculture Sustainability and Environmental Impact
- SARS-CoV-2 and COVID-19 Research
- Abdominal Surgery and Complications
Hospital Curry Cabral
2017-2025
Instituto Nacional de Traumatologia e Ortopedia
2024
University of Alberta
2014-2024
Universidade Nova de Lisboa
2024
Universidade de Brasília
2024
Centro Hospitalar de Lisboa Central
2022-2024
Nova Medical (United States)
2023
Hospital de Santa Marta
2022
University of Oxford
2021
Novartis (Switzerland)
2021
Hyperammonemia has been associated with intracranial hypertension and mortality in patients acute liver failure (ALF). We evaluated the effect of renal replacement therapy (RRT) on serum ammonia level outcomes ALF. This was a multicenter cohort study consecutive ALF from United States Study Group registry between January 1998 December 2016. First, we studied association hepatic encephalopathy (HE) 21‐day transplant‐free survival (TFS; n = 1,186). Second, RRT for first 3 days post admission...
C-reactive protein (CRP) has been used widely in the early risk assessment of patients with acute pancreatitis. This study evaluated prognostic accuracy CRP for severe pancreatitis (SAP), pancreatic necrosis (PNec), and in-hospital mortality (IM) terms best timing measurement optimal cutoff points.This was a single-center retrospective cohort including 379 consecutively admitted determinations at hospital admission, 24, 48, 72 h after admission were collected. Discriminative predictive...
BackgroundAcute kidney injury (AKI) is a serious complication following lung transplantation (LTx). We aimed to describe the incidence and outcomes associated with AKI LTx.
Abstract Background and Aims Patients with acute‐on‐chronic liver failure (ACLF) have high mortality rates. Most prognostic scores were not developed for the intensive care unit (ICU) setting. We aimed to improve risk stratification patients ACLF in ICU. Methods A training set 240 cirrhosis organ failures (Chronic Liver Failure Sequential Organ Assessment score [CLIF‐SOFA]) from Curry Cabral Hospital (Portugal) University of Alberta (Canada) 2010‐2016 was used derive a model ICU mortality....
Introduction: The concept of failure to rescue has been used measure the quality care for complications developed following surgery. poorly studied in patients with primary medical diseases, such as sepsis or acute liver (ALF). Methods: Retrospective multicenter cohort including consecutive ALF within United States Study Group (USALFSG) prospective registry from 2010 2016. rate 12 was calculated mortality events up 21 days post inclusion divided by complication registered on first day...
Spontaneous bacterial peritonitis (SBP) is a prevalent and high mortality complication of cirrhosis. We aimed to describe these patients' clinical microbiological characteristics evaluate their impact on outcomes.This was retrospective cohort study including 139 consecutive patients with positive culture SBP from three Portuguese centers diagnosed between 2009 2014. Multivariate logistic regression used associations 30-day mortality.The mean age the 62 years 81% were men. The model for...
Almost all reports on liver injury in patients with 2019 coronavirus disease (COVID-19) found blood tests to be frequently abnormal, especially more severe disease, but substantial heterogeneity [1].Moreover, tests' abnormalities were thought of doubtful clinical value.Most studies have described a single time point, usually at inclusion [2, 3].Therefore, we used our case series the first 20 consecutive COVID-19 admitted intensive care unit (ICU) Curry Cabral Hospital Lisbon, Portugal, from...
The impact of multidrug-resistant (MDR) colonization and MDR infection in critically ill cirrhosis patients remains unclear. We assessed the association with these patients’ survival. Observational cohort study including adult admitted to 5 intensive care units at Northwestern Memorial Hospital (Chicago, Illinois, USA) on January 1, 2010, December 31, 2017. Patients for elective liver transplant or previous were excluded. screened unit admission. Infection diagnoses during stay considered....
Previous studies have identified risk factors for severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) outcomes preferentially among hospitalized patients; therefore, they may understated the denominator of such estimations [1,2].We aimed to determine pre-hospital and estimate individual probabilities SARS-CoV2 a nationwide cohort cases infection, including those with without hospitalization.This was retrospective analysis from prospective registry, confirmed (nasal/pharynx swab...
Abstract In critical patients, abdominal perfusion pressure (APP) has been shown to correlate with outcome. However, data from cirrhotic patients is scarce. We aimed characterize APP in critically ill analyze the prevalence and risk factors of hypoperfusion (AhP) outcomes. A prospective cohort study a general ICU specialized liver disease at tertiary hospital center recruited consecutive between October 2016 December 2021. The included 101 mean age 57.2 (± 10.4) years female gender...
Introduction. To identify the impact of portal vein thrombosis (PVT) and associated medical surgical factors on outcomes post liver transplant (LT). Material methods. Two analyses were performed. Analysis One: cohort study 505 consecutive patients who underwent LT (Alberta) between 01/2002-12/2012. PVT was identified in 61 (14%) patients. Two: 144 from two sites (Alberta London) during same period. Cox multivariable survival analysis used to independent associations with post-LT mortality....
A adaptabilidade de caprinos dois grupos genéticos, Saanen e Azul, às condições climáticas do Meio-Norte Brasil foi avaliada por meio dos testes Ibéria, Benezra Rainsby. Nos primeiros, foram utilizadas sete fêmeas cada grupo racial e, no terceiro, quatro grupo. Foram realizadas coletas dados em período (chuvoso seco) 2005. Foi utilizado delineamento inteiramente ao acaso, fatorial 2x2 (duas raças períodos). Os valores coeficiente tolerância calor teste Ibéria seco diferiram entre os...
C-reactive protein (CRP) and Bedside Index for Severity in Acute Pancreatitis (BISAP) have been used early risk assessment of patients with AP. We evaluated prognostic accuracy CRP at 24 hours after hospital admission (CRP24) in-hospital mortality (IM) AP individually BISAP. This retrospective cohort study included 134 from a Portuguese 2009–2010. Prognostic area under receiver–operating characteristic curve (AUC), continuous net reclassification improvement (NRI), integrated discrimination...
Summary Background Serum ammonia variation in critically ill patients with cirrhosis has been poorly studied. Aim To describe and assess the impact of serum these patients' outcomes. Methods We studied ≥18 years old admitted to intensive care units (ICUs) at University Alberta Hospital (Edmonton, Canada) Curry Cabral (Lisbon, Portugal; derivation cohort, n = 492) Northwestern (Chicago, USA; validation 600) between January 2010 December 2021. Primary exposure was ICU days 1–3 ammonia....
BACKGROUND: Cirrhotic patients with Model for End-stage Liver Disease (MELD) score ≥40 have high risk death without liver transplant (LT). OBJECTIVE: To evaluate these patients’ outcomes after LT. METHODS: The present study analyzed a retrospective cohort of 519 cirrhotic adult who underwent LT at single Canadian centre between 2002 and 2012. Primary exposure was severity disease measured by MELD (≥40 versus <40). outcome duration first intensive care unit (ICU) stay Secondary were...
Recently, it has been suggested an association between red cell distribution width (RDW) and Crohn's disease activity index (CDAI), but its use is not yet performed in daily clinical practice.To determine whether RDW can be used as a marker of (CD) activity.This was cross-sectional study including patients with CD, observed consecutively outpatient setting January 1st September 30th 2013. Blood indices, erythrocyte sedimentation rate (ESR), C-reactive protein were measured. CD determined by...