A5007927701- Liver Disease and Transplantation
- Drug-Induced Hepatotoxicity and Protection
- Liver Disease Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Gallbladder and Bile Duct Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Poisoning and overdose treatments
- Electrolyte and hormonal disorders
- Acute Kidney Injury Research
- Hepatitis C virus research
- Autoimmune and Inflammatory Disorders Research
- Liver Diseases and Immunity
- Stoma care and complications
- Renal Transplantation Outcomes and Treatments
- Immune Cell Function and Interaction
- Hepatitis B Virus Studies
- Microscopic Colitis
- Pharmacogenetics and Drug Metabolism
- Renal function and acid-base balance
- Hematopoietic Stem Cell Transplantation
- Abdominal vascular conditions and treatments
- Acute Lymphoblastic Leukemia research
- Inflammatory Bowel Disease
- Biliary and Gastrointestinal Fistulas
The University of Texas Southwestern Medical Center
2012-2024
Southwestern Medical Center
2011-2024
University of Michigan
2011
A. Alfred Taubman Health Care Center
2011
Hyperammonemia has been associated with intracranial hypertension and mortality in patients acute liver failure (ALF). We evaluated the effect of renal replacement therapy (RRT) on serum ammonia level outcomes ALF. This was a multicenter cohort study consecutive ALF from United States Study Group registry between January 1998 December 2016. First, we studied association hepatic encephalopathy (HE) 21‐day transplant‐free survival (TFS; n = 1,186). Second, RRT for first 3 days post admission...
Abbreviated pathogenesis and clinical course of the acute liver failure syndrome. The syndrome (ALF) differs depending upon etiology primary injury. In turn, severity injury resulting synthetic is often determinant whether a patient referred for emergency transplantation. Injuries by viral etiologies trigger innate immune system via pathogen-associated molecular patterns (PAMPs), while toxin-induced (and presumably ischemia-induced) injuries do so damage-associated (DAMPs). further depends...
Autoimmune hepatitis is a common cause of acute liver failure. Treatment includes steroids for injury and transplantation in those who fail to respond or develop The aim this study further characterize failure secondary autoimmune identify variables that predict 21-day transplant-free survival. This included adults hospitalized with enrolled the Acute Liver Failure Study Group Registry between 1998 2019 from 32 centers within US. etiology all cases was reviewed by Adjudication Committee,...
Herbal and dietary supplements represent a multi-billion-dollar industry reportedly used by over half of American adults. However, these products are not regulated the Federal Drug Agency contain wide range contaminants, leading to 50,000 adverse events each year. This review aims highlight widespread use current regulatory status herbal supplements, identify presentation diagnostic dilemmas faced with liver injury, discuss most common agents implicated in supplement hepatotoxicity.
OBJECTIVES: Patients with chronic ulcerative colitis (UC) often refuse colectomy, despite data indicating that it might improve quality of life. We hypothesized perceived utility values are different for patients living UC compared after total proctocolectomy. Our aims were to compare the assigned by and without a colectomy standardized post-colectomy scenarios, actual health states among groups. METHODS: surveyed in tertiary referral center from three groups, including non-UC, who...
Goals: To describe the short-term and long-term outcomes in 34 consecutive decompensated cirrhotic patients with symptomatic gallbladder disease undergoing transpapillary stent (TGS) placement. Background: Endoscopic TGS placement is a minimally invasive means of treating poor surgical candidates. Study: Between June 2005 2011, cirrhosis underwent attempted Results: Median patient age was 52 years, 56% were hospitalized, 48% listed for liver transplantation. The median model end-stage (MELD)...
The number of simultaneous liver‐kidney transplantations (SLKTs) and use induction therapy for SLKT have increased recently, without much published evidence, especially in the context maintenance immunosuppression containing tacrolimus (TAC) mycophenolic acid (MPA). We queried Organ Procurement Transplant Network registry recipients maintained on TAC/MPA at discharge United States 2002–2016. cohort was divided into 3 groups basis type: rabbit antithymocyte globulin (r‐ATG; n = 831),...
Acute liver failure (ALF) is an orphan disease often complicated by acute kidney injury (AKI). We assessed the impact of transient versus persistent AKI on survival in patients with ALF.International multicenter retrospective cohort.U.S. ALF Study Group prospective registry.Patients greater than or equal to 18 years and registry from 1998 2016 were included. Patients less 3 days follow-up, without function evaluation day 3, cirrhosis excluded.AKI was defined Kidney Disease Improving Global...
Biliary atresia (BA) remains the number one indication for paediatric liver transplantation (LT) worldwide but is an uncommon older LT recipients. The impact of recent donor allocation changes, pervasive organ shortage and evolving practices on BA population unknown.We identified patients who underwent between January 2010 December 2021 using UNOS database. We compared clinical outcomes with those non-BA cholestatic disease. Groups were stratified by age, <12 years (allocated via PELD...
Abstract Background The etiology of acute liver failure (ALF) remains one the most important factors in determining prognosis and predicting outcomes. In a significant proportion ALF cases, however, unknown is categorized as indeterminate (IND‐ALF). this study, we summarize findings from patients with IND‐ALF 32 transplant centers across United States, compare laboratory, prognostic, outcome data for IND‐ALF. Methods Between 1998 2019, 3364 adult or injury (ALI) were enrolled ALFSG registry....
A 48-year-old man with hepatitis C virus (HCV) cirrhosis complicated by hepatocellular carcinoma underwent liver transplantation. His course was fever, diarrhea, abdominal pain, and pancytopenia. He developed a diffuse erythematous rash, which progressed to erythroderma. Biopsies of the colon skin were consistent acute graft-versus-host disease. Donor-derived lymphocytes present in peripheral blood. The patient treated corticosteroids cyclosporine; however, he had minimal response intensive...